Genes (94)
Species: human : 59 mouse : 35 | |
Mouse | RBM17 | 84991 | RNA binding motif protein 17 | Our effort to identify novel drug-resistant genes in cyclophosphamide-resistant EMT6 mouse mammary tumors led us to the identification of SPF45. | Mouse | SEPT9 | 10801 | septin 9 | The region, named SL3-3 integration site 1 (Sint1), maps to the distal end of mouse chromosome 11, corresponding to human chromosome 17q25, and may be identical to a mouse mammary tumor virus integration site in a T-cell lymphoma, Pad3. | Mouse | PEA15 | 8682 | phosphoprotein enriched in astrocytes 15 | MAT1 is a novel transforming gene which was cloned from a mouse mammary tumor induced by N-methyl-N-nitrosourea in vitro in the presence of lithium as a mitogen. | Mouse | AKR1C3 | 8644 | aldo-keto reductase family 1, member C3 | Overexpression of AKR1C1 and, to a lesser extent, AKR1C2 (but not AKR1C3) decreased progesterone-dependent PR activation of a mouse mammary tumor virus promoter in both prostate (PC-3) and breast (T-47D) cancer cell lines. | Mouse | WNT9B | 7484 | wingless-type MMTV integration site family, member 9B | No significant elevation of Wnt9b expression was detected in 29 mouse mammary tumor virus-induced tumors. | Mouse | WNT3 | 7473 | wingless-type MMTV integration site family, member 3 | In mouse mammary tumors, the Wnt-3 gene can be activated by proviral insertion. This family includes Wnt-1 and Wnt-3, both discovered as activated oncogenes in mouse mammary tumors. Wnt-3, a gene activated by proviral insertion in mouse mammary tumors, is homologous to int-1/Wnt-1 and is normally expressed in mouse embryos and adult brain. | Mouse | UBE3A | 7337 | ubiquitin protein ligase E3A | There is no obvious correlation between p53 (a well-characterized substrate of E6-AP) status (wt vs. mutant) and levels of E6-AP in the mouse mammary tumors. | Mouse | NR2F1 | 7025 | nuclear receptor subfamily 2, group F, member 1 | Dual transcriptional control by Ear3/COUP: negative regulation through the DR1 direct repeat and positive regulation through a sequence downstream of the transcriptional start site of the mouse mammary tumor virus promoter. | Mouse | SDC1 | 6382 | syndecan 1 | Using syndecan-1 deletion mutants, we show that the extracellular part of the molecule (ectodomain) can suppress malignant growth, stimulate actin polymerization, and induce epithelioid morphology in mouse mammary tumor Shionogi 115 (S115) cells. | Mouse | S100A4 | 6275 | S100 calcium binding protein A4 | Expression of Mts1, a metastasis-associated gene, increases motility but not invasion of a nonmetastatic mouse mammary adenocarcinoma cell line. | Mouse | PTGER3 | 5733 | prostaglandin E receptor 3 (subtype EP3) | Regulation of vascular endothelial cell growth factor expression in mouse mammary tumor cells by the EP2 subtype of the prostaglandin E2 receptor. | Mouse | OSM | 5008 | oncostatin M | We examined the effects of OSM on the proliferation and metastatic potential of the murine mammary carcinoma cell lines M6 (adenocarcinoma) and M6c (metastatic adenocarcinoma). | Mouse | NOTCH4 | 4855 | notch 4 | Intracisternal type A particle-mediated activation of the Notch4/int3 gene in a mouse mammary tumor: generation of truncated Notch4/int3 mRNAs by retroviral splicing events. INT3 is interrupted by retroviral DNA insertion in approximately 18% of primary Czech mouse mammary tumors induced by mouse mammary tumor virus. One of these, designated Notch-4, was found to be a common integration site for the mouse mammary tumor virus in mouse mammary tumors. The vertebrate Notch1 and Notch4 homologs are involved in normal development of the mammary gland, and mutated forms of these genes are associated with development of mouse mammary tumors. Mouse mammary tumor gene int-3: a member of the notch gene family transforms mammary epithelial cells. Expression of the int-3 locus is activated in mouse mammary tumors as a consequence of insertional mutagenesis by the mouse mammary tumor virus (MMTV). In a mouse mammary tumor model system in which carcinogenic progression can be investigated, we have found a unique mutation of Int-3 associated with progression from premalignant lobular hyperplasia to tumor. In one spontaneous mammary tumor, no. 9, that developed in a BALB/c mouse, we have found an insertion of a 1.2-kb sequence, consisting of a 5; long terminal repeat and gag sequences of an intracisternal type A particle (IAP) as well as an extra copy of the Notch4/int3 genomic sequences containing exons 23 and 24, into the intron between exons 24 and 25 of the Notch4/int3 gene. | Mouse | NOTCH1 | 4851 | notch 1 | Involvement of Notch1 in the development of mouse mammary tumors. | Mouse | NOS3 | 4846 | nitric oxide synthase 3 (endothelial cell) | In this review, we discuss these mechanisms on the basis of data derived from experimental models, in particular, a mouse mammary tumor model in which the expression of eNOS by tumor cells is positively correlated with invasive and metastatic abilities. | Mouse | NME1 | 4830 | NME/NM23 nucleoside diphosphate kinase 1 | With regard to nm23, downregulation of nm23 RNA levels in high metastatic potential cells has been demonstrated in a wide variety of rodent metastasis systems, including K-1735 murine melanoma cell lines, nitrosomethylurea-induced rat mammary tumors, MMTV-induced mouse mammary tumors, and ras +/- E1a transfected rat embryo fibroblasts. Murine mammary tumors induced by the Murine Mammary Tumor Virus (MMTV) were chosen to study the expression of the NM23 gene during the metastatic process because of their viral etiology, different from that of the previously reported experimental tumor systems. Murine mammary tumors induced by the Murine Mammary Tumor Virus (MMTV) were chosen to study the expression of the NM23 gene during the metastatic process because of their viral etiology, different from that of the previously reported experimental tumor systems. Decreasing expression of NM23 gene in metastatic murine mammary tumors of viral etiology (MMTV). | Mouse | NID1 | 4811 | nidogen 1 | On a weight basis entactin was as effective as laminin in promoting the attachment of mouse mammary tumor cells. Mouse entactin derived from the extracellular matrix of M1536-B3 cells and from insect cells infected with a recombinant virus containing entactin sequences were shown to promote the attachment of mouse mammary tumor, human melanoma, and other cells. | Mouse | EIF3E | 3646 | eukaryotic translation initiation factor 3, subunit E | The Int6 gene is a common insertion site for the mouse mammary tumor virus (MMTV) in mouse mammary tumors. The chromosomal location of the mouse mammary tumor gene Int6 and related pseudogenes in the mouse genome. The INT6 gene is a common integration site for the mouse mammary tumor virus in mouse mammary tumors. PURPOSE: The Int6 gene was originally identified as a common insertion site for the mouse mammary tumor virus in virally induced mouse mammary tumors. The Int-6 protein has been originally identified as the product of a mouse gene being a frequent integration site of the mouse mammary tumour virus. | Mouse | GRPR | 2925 | gastrin-releasing peptide receptor | PURPOSE: In view of these findings, we investigated the effects of our synthetic bombesin and gastrin-releasing peptide receptor antagonist D-Tpi6,Leu13 psi (CH2NH)-Leu14 bombesin(6-14) (RC-3095) on the growth of hormone-dependent and hormone-independent MXT mouse mammary cancers in vivo. | Mouse | GPC1 | 2817 | glypican 1 | The majority of the cooperative targets display increased expression in tumors derived from either Min (many intestinal neoplasia) or mouse mammary tumor virus (MMTV)-Wnt1 mice, two models of Wnt-induced tumors, with nine of these genes (Ankrd1, Ccnd1, Ctgf, Gpc1, Hs6st2, IL11, Inhba, Mmp14, and Robo1) showing increases in both. | Mouse | GHRH | 2691 | growth hormone releasing hormone | Our results demonstrate that GHRH antagonists decrease the local production of both GH and IGF-I in MXT mouse mammary cancers, the resulting growth inhibition being the consequence of reduced cell proliferation and increased apoptosis. GHRH antagonists JV-1-36 and JV-1-38 inhibited growth of estrogen-independent MXT mouse mammary cancers in vivo, producing about 50% reduction in tumor volume (P < 0.05). | Mouse | FGF8 | 2253 | fibroblast growth factor 8 (androgen-induced) | Activation of Fgf8 in S115 mouse mammary tumor cells is associated with genomic integration of mouse mammary tumor virus. S115 mouse mammary tumor cells express a transformed phenotype and secrete FGF-8 in an androgen-dependent manner. In conclusion, our data provide evidence that the insertion of MMTV into the DD/Sio tumor DNA is associated with the transcriptional activation of Fgf8 in DD/Sio tumor and consequently in S115 mouse mammary tumor cells. | Mouse | FGF7 | 2252 | fibroblast growth factor 7 | The effect of hormones on KGF mitogenesis and the regulation of KGFR expression was examined in pregnancy-dependent (PDT) and ovarian-independent (OIT) mouse mammary tumors. | Mouse | FGF4 | 2249 | fibroblast growth factor 4 | These results demonstrated that the hst gene may contribute to tumor progression from a nonmetastatic to a metastatic phenotype in the mouse mammary tumor system. | Mouse | FGF1 | 2246 | fibroblast growth factor 1 (acidic) | Androgen and fibroblast growth factor (FGF) regulation of FGF receptors in S115 mouse mammary tumor cells. |
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