Human | C9orf86 | 55684 | | RBEL1A and RBEL1B are novel Rab-like proteins that localize in the nucleus and cytosol and may play an important role in breast tumorigenesis |
Human | PELP1 | 27043 | proline, glutamate and leucine rich protein 1 | PELP1 is a coactivator of estrogen receptor (ER), interacts with ER, and may have a role in mammary tumorigenesis |
Human | HPSE | 10855 | heparanase | Heparanase induction by estrogen receptors represents an important pathway in breast tumorigenesis and may be responsib, for failure of tamoxifen therapy in some patients |
Human | HOXB13 | 10481 | homeobox B13 | Hypermethylation of HOXB13 is a late event of breast tumorigenesis |
Human | GAB2 | 9846 | GRB2-associated binding protein 2 | role for Gab2 in mammary tumorigenesis |
Human | PRC1 | 9055 | protein regulator of cytokinesis 1 | suggest the involvement of a PRC1- kinesin family member 2C/mitotic centromere-associated kinesin complex in breast tumorigenesis, and this complex should be a promising target for the development of novel treatments for breast cancer |
Human | IQGAP1 | 8826 | IQ motif containing GTPase activating protein 1 | IQGAP1 enhances mammary tumorigenesis, suggesting that it may be a target for therapeutic intervention |
Human | PPM1D | 8493 | protein phosphatase, Mg2+/Mn2+ dependent, 1D | Operates within the map kinase kinase 6/p38 map kinase signaling pathway to promote ErbB2-driven mammary gland tumorigenesis in transgenic mice |
Human | NCOA3 | 8202 | nuclear receptor coactivator 3 | HER2/Neu and ACTR may synergize to orchestrate mammary tumorigenesis through the dysregulation of the transcription factor ER81 and its target genes |
Human | TFF2 | 7032 | trefoil factor 2 | TFF2 could play a role in mammary gland tumorigenesis |
Human | AURKA | 6790 | aurora kinase A | p53 and p16 are critical in preventing mammary gland tumorigenesis in the human Aurora A overexpression mouse model |
Human | RARA | 5914 | retinoic acid receptor, alpha | the silencing of the RAR alpha2 promoter by hypermethylation may play a contributory role in the dysregulation of RA signaling in mammary tumorigenesis |
Human | MDM2 | 4193 | MDM2 oncogene, E3 ubiquitin protein ligase | SNP309G/G is associated with poor prognostic breast cancer features in the Scottish population; a novel SNP, SNP285, that is in linkage disequilibrium with SNP309, may also have a role in breast tumorigenesis |
Human | CYR61 | 3491 | cysteine-rich, angiogenic inducer, 61 | Cyr61 promotes breast tumorigenesis and cancer progression |
Human | IGFBP3 | 3486 | insulin-like growth factor binding protein 3 | the expression level of IGFBP3 in breast tissues may be involved in breast tumorigenesis |
Human | IGF1R | 3480 | insulin-like growth factor 1 receptor | the expression of IGF-I and IGFIR genes may undergo substantial change over the course of breast tumorigenesis, and the pattern of changes may be associated with breast cancer prognosis |
Human | IGF1 | 3479 | insulin-like growth factor 1 (somatomedin C) | the expression of IGF-I and IGFIR genes may undergo substantial change over the course of breast tumorigenesis, and the pattern of changes may be associated with breast cancer prognosis |
Human | EZH2 | 2146 | enhancer of zeste homolog 2 (Drosophila) | We summarize the current knowledge on the function of EZH2 in cancer, with special focus on breast cancer, and propose a link between EZH2, the homologous recombination pathway of DNA repair, and breast tumorigenesis |
Human | ETV1 | 2115 | ets variant 1 | transcription factor ER81 is regulated by oncogenic HER2/Neu and ACTR in mammary tumorigenesis |
Human | ERBB2 | 2064 | v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 | HER2/Neu and ACTR may synergize to orchestrate mammary tumorigenesis through the dysregulation of the transcription factor ER81 and its target genes Signaling by HER-2/neu has a critical role in the early stages of breast tumorigenesis Diets enriched with corn or fish reduced mammary tumorigenesis in Her-2 transgenic mice |
Human | CTSK | 1513 | cathepsin K | CTSK may function as a paracrine factor in breast tumorigenesis |
Human | CST6 | 1474 | cystatin E/M | Methylation-dependent epigenetic silencing of CST6 represents an important mechanism for loss of CST6 during breast tumorigenesis and/or progression to metastasis |
Human | BRCA1 | 672 | breast cancer 1, early onset | transcriptionally regulates genes involved in breast tumorigenesis |
Human | AHR | 196 | aryl hydrocarbon receptor | studies suggest that constitutively active AhR mediates different molecular outcomes than environmental chemical-activated AhR, and further implicate the AhR in mammary tumorigenesis |