Human | GPR116 | 221395 | G protein-coupled receptor 116 | SEA domain autoproteolysis accelerated by conformational strain SEA domain autoproteolysis accelerated by conformational strain: mechanistic aspects |
Human | ACE2 | 59272 | angiotensin I converting enzyme 2 | Here we show that transgenic mice that express the SARS-CoV receptor (human angiotensin-converting enzyme 2 [hACE2]) in airway and other epithelia develop a rapidly lethal infection after intranasal inoculation with a human strain of the virus functions as a receptor for hCOV NL63 and 229E S proteins but is engaged diferentially by each strain |
Human | PALLD | 23022 | palladin, cytoskeletal associated protein | Palladin was up-regulated in adipose-derived adult stem cells during osteogenic differentiation and cyclic tensile strain |
Human | PRG4 | 10216 | proteoglycan 4 | Lubricin provides synovial fluid with an ability to dissipate strain energy induced by mammalian locomotion, which is a chondroprotective feature that is distinct from boundary lubrication |
Human | MVP | 9961 | major vault protein | Sequence analysis and molecular modeling were used to show that MVP and the toxic anion resistance protein, TelA of Rhodobacter sphaeroides strain 2.4.1, share a novel fold that consists of a three-stranded antiparallel beta-sheet |
Human | SLC16A4 | 9122 | solute carrier family 16, member 4 | an exercise protocol designed to strain muscle carbohydrate reserves and to result in large increases in lactic acid results in a rapid upregulation of both GLUT-4 and MCT-4 |
Human | TNFSF11 | 8600 | tumor necrosis factor (ligand) superfamily, member 11 | biological responses of OPG and sRANKL synthesis in osteoblasts to the application of cyclic tensile strain are regulated via the p38 MAPK pathway |
Human | CXCR4 | 7852 | chemokine (C-X-C motif) receptor 4 | coreceptor binding domain, the V3 region of the surface envelope (SU) glycoprotein, was replaced by the V3 loop of a CD4- and CXCR4-tropic HIV-1 strain; the resulting virus, termed SIVagm3-X4mc, exclusively used CD4 and CXCR4 for cell entry |
Human | WIPF1 | 7456 | WAS/WASL interacting protein family, member 1 | Only in the presence of WASP-interacting protein (WIP) can human WASP suppress the growth defect of Saccharomyces cerevisiae las17Delta strain |
Human | WAS | 7454 | Wiskott-Aldrich syndrome | Human WASP suppresses the growth defect of Saccharomyces cerevisiae las17Delta strain, only in the presence of WASP-interacting protein (WIP) |
Human | UNG | 7374 | uracil-DNA glycosylase | crystallization reveals example of geometric strain, least atomic motion, and electrophile migration in biological catalysis |
Human | TNF | 7124 | tumor necrosis factor | Serotype III Group b Streptococcus strain stimulated significantly greater tumor necrosis factor alpha (TNF-alpha) (P < 0.0001) production than did serotype VIII strain in A549 epithelial cells |
Human | TLR5 | 7100 | toll-like receptor 5 | TLR5 is activated in intestinal epithelial cells by a commensal Escherichia coli strain |
Human | TIAM1 | 7074 | T-cell lymphoma invasion and metastasis 1 | Tiam1, a Rac1-specific guanine nucleotide exchange factor, was expressed mainly in the cytosol of AT2 cells exposed to mechanical strain compared with membrane localization in static cells |
Human | TGFB1 | 7040 | transforming growth factor, beta 1 | Together, these findings show that TGFbeta superfamily activation of Smad2/3 is required for repression of spontaneous differentiation under strain |
Human | TERT | 7015 | telomerase reverse transcriptase | Expression of hTERT in normal fibroblast cell strain resulted in telomerase activity and an extended proliferative lifespan |
Human | STAT3 | 6774 | signal transducer and activator of transcription 3 (acute-phase response factor) | results show STP-A11 (Saimiri transforming protein oncogne of Herpesvirus saimiri subgroup A strain 11) independently targets two important cellular signaling molecules, Src and Stat3; these proteins cooperate to induce STP-A11-mediated transformation |
Human | SLC2A4 | 6517 | solute carrier family 2 (facilitated glucose transporter), member 4 | an exercise protocol designed to strain muscle carbohydrate reserves and to result in large increases in lactic acid results in a rapid upregulation of both GLUT-4 and MCT-4 |
Human | S100B | 6285 | S100 calcium binding protein B | S-100beta concentrations do not necessarily increase in response to exercise-heat strain, and no effect of heat acclimation on S-100beta could be observed despite other quantifiable physiological adaptations |
Human | RAC1 | 5879 | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | rhoA and rac-1 participate in cell sensitivity to mechanical strain and lead to the modulation of the Erk pathway |
Human | PXN | 5829 | paxillin | Alpha4beta1-dependent adhesion strengthening under mechanical strain is regulated by paxillin association with the alpha4-cytoplasmic domain |
Human | MAPK3 | 5595 | mitogen-activated protein kinase 3 | Helicobacter pylori-induced ERK1 activation, especially by the cagA(+) strain, may play a protective role against gastric epithelial cell apoptosis partially through maintenance of bcl-2 gene expression |
Human | MAPK1 | 5594 | mitogen-activated protein kinase 1 | Helicobacter pylori-induced ERK2 activation, especially by the cagA(+) strain, may play a protective role against gastric epithelial cell apoptosis partially through maintenance of bcl-2 gene expression |
Human | PLG | 5340 | plasminogen | Strain ST1 of L. crispatus enhanced activation of human Plg by the tissue-type Plg activator (tPA), whereas enhancement of the urokinase-mediated Plg activation was lower |
Human | PIGR | 5284 | polymeric immunoglobulin receptor | facilitates invasion of epithelial cells by Streptococcus pneumoniae in a strain-specific and cell type-specific manner |