Mouse | PLAA | 9373 | phospholipase A2-activating protein | PEG-PLAP treatment increased the life expectancy of animals with Lewis lung cancer, and in preliminary studies in MTVL breast tumors in mice, PLAP treatment resulted in a similar increase in life expectancy. |
Mouse | STAT5B | 6777 | signal transducer and activator of transcription 5B | Continuous activation of Stat5 indicates a role of this transcription factor in normal, nonpregnant breast epithelial cells, and may shed new light on Stat5 involvement in breast tumor promotion. |
Mouse | FXYD3 | 5349 | FXYD domain containing ion transport regulator 3 | We recently identified a novel 8-kDa transmembrane protein, Mat-8, that is expressed in a subset of murine breast tumors. |
Mouse | MAGEB1 | 4112 | melanoma antigen family B, 1 | A DNA-based vaccine was developed from transcripts of one of the 64pT tumors, encoding the complete Mage-b1/2 protein, and subsequently tested for its preventive efficacy in both breast tumor models. |
Mouse | IGFBP3 | 3486 | insulin-like growth factor binding protein 3 | Insulin-like growth factor binding protein-3 is overexpressed in endothelial cells of mouse breast tumor vessels. |
Mouse | FGF1 | 2246 | fibroblast growth factor 1 (acidic) | FGF-1 is expressed in a high proportion of breast tumors. |
Mouse | BRCA2 | 675 | breast cancer 2, early onset | Cre-mediated deletion of exons 3 and 4 of the mouse Brca2 gene occurring specifically in mammary epithelial cells of conditional female mutants carrying a combination of loxP-modified and null Brca2 alleles resulted in a high incidence (77%) of breast tumors that were often palpable and developed in one or more glands after long latency (time for median tumor-free survival of approximately 1.4 years; total of 40 tumors in 20 animals). |
Human | CD24 | 100133941 | CD24 molecule | analysis of CD44 and CD24 expression in breast tumors |
Human | LOC729249 | 729249 | | Here, we report that Mayven expression was abundant and diffuse in primary human epithelial breast tumor cells as compared to normal breast epithelial cells, where Mayven was detected in the normal breast layer of the mammary ducts. |
Human | MUC5B | 727897 | mucin 5B, oligomeric mucus/gel-forming | The highest frequencies of positive RT-PCR tests in breast tumor extracts were observed for MUC5B (7/15) and MUC7 (5/12). Using a nested RT-PCR, MUC5B mRNA transcripts were detected in 16/31 primary breast tumors (but not in 36 samples of normal PBMN cells) and in the human MCF-7 breast cancer cell line but not in BT20, MDA, T47D and ZR-75 breast cancer cell lines, indicating that MUC5B mRNA is expressed in a population of breast cancer cells. |
Human | SFTPA1 | 653509 | surfactant protein A1 | INFERRED, Score=800, UMLKSK CUI: C1458155 |
Human | ERVK7 | 449619 | | Click here to display 7 evidence detail records. |
Human | TUBB2B | 347733 | tubulin, beta 2B class IIb | The class II beta-tubulin isotype seems to be a promising predictive marker of docetaxel activity in the treatment of breast neoplasms |
Human | NEK8 | 284086 | NIMA-related kinase 8 | Nek8, a NIMA family kinase member, is overexpressed in primary human breast tumors. Nek8 is differently expressed between normal human breast tissue and breast tumors. |
Human | MAPK15 | 225689 | mitogen-activated protein kinase 15 | Loss of ERK7 was correlated with breast cancer progression, and all ER alpha-positive breast tumors had decreased ERK7 expression compared to that found in normal breast tissue. |
Human | PAOX | 196743 | polyamine oxidase (exo-N4-amino) | SSAT and SMO(PAOh1) activities are the major mediators of the cellular response of breast tumor cells to polyamines while PAO plays little or no role in this response |
Human | PSORS1C2 | 170680 | psoriasis susceptibility 1 candidate 2 | Click here to display 6 evidence detail records. |
Human | TMPRSS6 | 164656 | transmembrane protease, serine 6 | Matriptase-2 suppresses breast tumor development in vivo, displays prognostic value for breast cancer patients, inhibits both breast cancer cell invasion and motility in vitro, and may play a contrasting role to matriptase-1 in breast cancer |
Human | CITED4 | 163732 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 | In contrast to the nuclear localization of CITED4 in normal breast tissue, breast tumors were characterized by cytoplasmic and nuclear localization. |
Human | AGR3 | 155465 | anterior gradient 3 | Click here to display 4 evidence detail records. |
Human | SLC2A12 | 154091 | solute carrier family 2 (facilitated glucose transporter), member 12 | Here we present the first demonstration of GLUT12 expression in human breast tumours. |
Human | CTCFL | 140690 | CCCTC-binding factor (zinc finger protein)-like | The ability of BORIS to activate promoters of the RP and ER genes points towards possible involvement of BORIS in the establishment, progression and maintenance of breast tumours |
Human | MUCL1 | 118430 | mucin-like 1 | Click here to display 5 evidence detail records. |
Human | PRKCDBP | 112464 | protein kinase C, delta binding protein | The down-regulation of hSRBC expression in cancer cells was associated with hypermethylation of CpG dinucleotides in its promoter region, and 3 (60%) of 5 primary breast tumors and 11 (79%) of 14 primary lung tumors were also found to be hypermethylated. |
Human | CGB8 | 94115 | chorionic gonadotropin, beta polypeptide 8 | These observations suggest that it is mainly the CGB8, B5 and B3 genes which are upregulated in the 19q13.3 CGB gene cluster in breast tumors. We found that the emergence of the ;trophoblastic; CGB genes in breast tumors is (i) accompanied by an increase in the total CGB mRNA steady-state level, (ii) mainly due to overexpression of genes CGB8, B5 and B3 (expression of other genes in the CGB/LHB gene cluster (CGB7, B2, B1 and LHB) changes little if at all), and (iii) not accompanied by overexpression of the CGA gene which is necessary to produce ectopic hCG heterodimeric hormone in breast tumor cells, these latter which yet expressed the LH/CG receptor. |