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Genes (30)
Species: human : 30 | |
Human | ADIPOR2 | 79602 | adiponectin receptor 2 | Lower AdipoR after kidney transplantation may be secondary to immunosuppression and/or an improvement in glomerular filtration rate and the uremic milieu | Human | FOXP3 | 50943 | forkhead box P3 | Evidence is provided that the increase of CD4+CD25 high T cells and FoxP3 transcripts is associated with operational tolerance in liver transplanted patients during immunosuppression withdrawal FoxP3, a key regulator of immune suppression, is not only expressed by regulatory T cells but also by melanoma cells, Epstein Barr virus-transformed B cells, and a wide variety of tumor cell lines | Human | CD209 | 30835 | CD209 molecule | These data suggest that DC-SIGN cannot be considered as the unique DC receptor for BCG internalization, and it is more interesting that the mycobacteria-induced immunosuppression cannot be attributed to the engagement of a single receptor | Human | LILRB2 | 10288 | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 | subtle structural differences between LILRB family members cause the distinct binding specificities to various forms of HLA-G and other MHCIs, which may in turn regulate immune suppression | Human | SGPL1 | 8879 | sphingosine-1-phosphate lyase 1 | Data suggest that lymphocyte trafficking is particularly sensitive to variations in sphingosine 1-phosphate lyase (S1PL) activity and suggest that there is a window in which partial inhibition of S1PL could produce therapeutic levels of immunosuppression | Human | TNFRSF6B | 8771 | tumor necrosis factor receptor superfamily, member 6b, decoy | elucidates a novel mechanism of DcR3-mediated immunosuppression | Human | TNFSF9 | 8744 | tumor necrosis factor (ligand) superfamily, member 9 | selective immunosuppression through MSCs may perhaps occur partly through an increase in CD137L+ on T-lymphocytes | Human | KMO | 8564 | kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) | the function KMO AND indoleamine 2,3-dioxygenase may change from a role in immunosuppression at the maternal-fetal interface in early pregnancy, to one associated with regulation of fetoplacental blood flow or placental metabolism in late gestation | Human | MIA | 8190 | melanoma inhibitory activity | MIA may contribute to immunosuppression frequently seen in malignant melanomas by inhibiting cellular antitumor immune reactions | Human | WT1 | 7490 | Wilms tumor 1 | cases with increase of WT1 levels after hematopoietic stem cell transplant and without graft vs. host disease may be candidate to discontinuation of immunosuppression and/or donor lymphocyte infusion therapy | Human | TNF | 7124 | tumor necrosis factor | Title:Cytokine gene polymorphisms in children successfully withdrawn from immunosuppression after liver transplantation.|Association:Not Found|Conclusion:Children successfully maintained off immunosuppression are more likely to have a genetic predisposition toward low TNF-alpha and high/intermediate IL-10 production. Children maintained on minimal immunosuppression exhibit a similar cytokine profile to those successfully weaned. | Human | TGFB1 | 7040 | transforming growth factor, beta 1 | tumor-derived TGFbeta-1 induces immunosuppression within sentinel lymph nodes (SLNs) before the movement of tumor cells into the SLNs, thereby facilitating metastasis within those nodes 'large' molecular weight molecules, the most important of which appears to be TGFbeta(1), make a significant contribution to immunosuppression by human seminal plasma calcineurin-induced reduction of Treg or TGF-beta expression predisposes nontransplanted tissue to inflammation, but indicate that combined immunosuppression hampers Treg development in the intestine Polymorphism in this gene affects immunosuppression in stable kidney transplantation Title:Cytokine gene polymorphisms in children successfully withdrawn from immunosuppression after liver transplantation.|Association:Not Found|Conclusion:Children successfully maintained off immunosuppression are more likely to have a genetic predisposition toward low TNF-alpha and high/intermediate IL-10 production. Children maintained on minimal immunosuppression exhibit a similar cytokine profile to those successfully weaned. | Human | CXCL12 | 6387 | chemokine (C-X-C motif) ligand 12 | Title:The impact of polymorphisms in chemokine and chemokine receptors on outcomes in liver transplantation.|Association:Not Found|Conclusion:In conclusion, CCR2-641, CCR5delta32, and SDF1-3'A genotypes did not influence the risk for acute rejection or graft survival. However, in liver allograft recipients SDF1-3'A is significantly associated with higher mortality. | Human | RHD | 6007 | Rh blood group, D antigen | relatively high perioperative transfusion needs of D- orthotopic liver transplantation recipients can be safely met with D+ components with very low risk of inducing anti-D with the newer, mycophenolate mofetil-centered immune suppression regimen | Human | RAF1 | 5894 | v-raf-1 murine leukemia viral oncogene homolog 1 | These data suggest that GILZ contributes, through protein-to-protein interaction with Raf-1 and the consequent inhibition of Raf-MEK-ERK activation, to regulating the MAPK pathway and to providing a further mechanism underlying GCH immunosuppression | Human | PRKAA1 | 5562 | protein kinase, AMP-activated, alpha 1 catalytic subunit | repeated, high-intensity exercise that leads to clinically relevant immunosuppression may do so via AMPK inactivation within immune cells | Human | FURIN | 5045 | furin (paired basic amino acid cleaving enzyme) | Data suggest that furin levels in cystic fibrosis respiratory epithelial cells contributes to bacterial toxin-induced cell death, fibrosis, and local immunosuppression | Human | MTHFR | 4524 | methylenetetrahydrofolate reductase (NAD(P)H) | Individuals carrying MTHFR 677T allele had marked increase in risk of squamous cell carcinoma after adjustment for age, ender, skin type, sun exposure score, and immunosuppression duration | Human | LIF | 3976 | leukemia inhibitory factor | Results describe the role of leukemia inhibitory factor in human mesenchymal stem cell-mediated immunosuppression | Human | IDO1 | 3620 | indoleamine 2,3-dioxygenase 1 | Downregulation of MHC class I expression by Indoleamine 2,3-dioxygenase(IDO) might be one of the mechanisms through which IDO mediates local immunosuppression the function of IDO and kynurenine hydroxylase may change from a role in immunosuppression at the maternal-fetal interface in early pregnancy, to one associated with regulation of fetoplacental blood flow or placental metabolism in late gestation | Human | IL10 | 3586 | interleukin 10 | although CD4+ CD25+ T regulatory cells induced by IL-10 seem to contribute to aspects of sepsis-induced lymphoid immune suppression, the oblation of CD25+ cells does not provide a survival advantage or disadvantage 'large' molecular weight molecules, the most important of which appears to be TGFbeta(1), make a significant contribution to immunosuppression by human seminal plasma | Human | IL6 | 3569 | interleukin 6 (interferon, beta 2) | Title:Cytokine gene polymorphisms in children successfully withdrawn from immunosuppression after liver transplantation.|Association:Not Found|Conclusion:Children successfully maintained off immunosuppression are more likely to have a genetic predisposition toward low TNF-alpha and high/intermediate IL-10 production. Children maintained on minimal immunosuppression exhibit a similar cytokine profile to those successfully weaned. | Human | IL2RA | 3559 | interleukin 2 receptor, alpha | although CD4+ CD25+ T regulatory cells induced by IL-10 seem to contribute to aspects of sepsis-induced lymphoid immune suppression, the oblation of CD25+ cells does not provide a survival advantage or disadvantage | Human | IFNG | 3458 | interferon, gamma | Hypermethylation of the interferon gamma gene among tumor-infiltrating lymphocytes is a mechanism of tumor induced immunosuppression Title:Cytokine gene polymorphisms in children successfully withdrawn from immunosuppression after liver transplantation.|Association:Not Found|Conclusion:Children successfully maintained off immunosuppression are more likely to have a genetic predisposition toward low TNF-alpha and high/intermediate IL-10 production. Children maintained on minimal immunosuppression exhibit a similar cytokine profile to those successfully weaned. | Human | HMOX1 | 3162 | heme oxygenase (decycling) 1 | Foxp3 induces HO-1 expression and HO-1 engages in Foxp3-mediated immune suppression |
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