Genes (50)
Species: human : 49 mouse : 1 | |
Mouse | ERAS | 3266 | ES cell expressed Ras | At the termination of the study, lung tumors (alveolar-bronchiolar epithelial neoplasms and hemangiosarcomas) and focal alveolar-bronchiolar hyperplasias were present in both sexes of Hras2 and non-Tg mice treated with VC; there were significantly more proliferative lung lesions in Hras2 than non-Tg mice. | Human | CD24 | 100133941 | CD24 molecule | CD24 constitutes an important molecular marker for various epithelial neoplasms | Human | GGT2 | 728441 | gamma-glutamyltransferase 2 | The increased GGT activity observed in all nine carcinomas arising from seven different organs suggests that GGT may be a common marker of human epithelial tumors and staining for GGT may become a useful tool in the detection of human epithelial neoplasms. Thus, GGT appears to be expressed during the development of malignant squamous epithelial neoplasms of the oral-pharyngeal-laryngeal region. Gamma glutamyl transpeptidase (GGT) is an enzyme expressed by some epithelial neoplasms but not normal interfollicular epidermis. | Human | BMF | 90427 | Bcl2 modifying factor | Bmf is a central mediator of anoikis in mammary cells and a target of oncogenes that contribute to the progression of glandular epithelial tumors | Human | MIB1 | 57534 | mindbomb E3 ubiquitin protein ligase 1 | In this immunohistochemical study, 80% of all vulvar intra-epithelial neoplasia were positive of MIB1 protein | Human | ODAM | 54959 | odontogenic, ameloblast asssociated | Data suggest that ODAM is a developmental antigen that has an essential role in tooth maturation and in the pathogenesis of certain odontogenic and other epithelial neoplasms | Human | CLDN18 | 51208 | claudin 18 | CLDN18.2 as a novel, highly attractive pan-cancer target for the antibody therapy of epithelial tumors | Human | CASP14 | 23581 | caspase 14, apoptosis-related cysteine peptidase | caspase-14 is aberrantly expressed in epithelial tumors | Human | SPINK5 | 11005 | serine peptidase inhibitor, Kazal type 5 | Early development of multiple epithelial neoplasms in Netherton syndrome. We report a case of Netherton syndrome manifested as congenital ichthyosiform erythroderma, trichorrhexis invaginata and atopy, who in early adulthood developed multiple, aggressive epithelial neoplasms in sun-exposed areas of the skin, in areas with papillomatous skin hyperplasia and at the left parotid region. | Human | BCL2L10 | 10017 | BCL2-like 10 (apoptosis facilitator) | Tumor-specific alterations in Bcl-B expression may define subsets of nonepithelial and epithelial neoplasms with distinct clinical behaviors | Human | NMT2 | 9397 | N-myristoyltransferase 2 | Based on our previous findings of elevated N-myristoyltransferase (NMT) activity in colonic epithelial neoplasms that appears at an early stage in colonic carcinogenesis, together with elevated NMT expression in human colorectal and gallbladder carcinomas, we investigated NMT activity and protein expression of NMT1 and NMT2 in human brain tumors and documented elevated NMT activity and higher protein expressions. | Human | NRP1 | 8829 | neuropilin 1 | neuropilin-1 is expressed in the prostatic stromal cells, not epithelial tumor cells, and this expression is significantly increased in the malignant phenotype | Human | WT1 | 7490 | Wilms tumor 1 | WT1 expression in epithelial tumors of the female genital tract may be related to cell differentiation and histologic subtypes of carcinomas, rather than to primary site of origin | Human | TP53 | 7157 | tumor protein p53 | In this immunohistochemical study, 80% of all vulvar intra-epithelial neoplasia were negative for p53 tumor suppressor protein | Human | SLC3A2 | 6520 | solute carrier family 3 (amino acid transporter heavy chain), member 2 | The CD98 reactivity on the proliferative basal layer of epithelium was a usual finding, as its detection in epithelial neoplasms and proliferative states is well known. | Human | SGK1 | 6446 | serum/glucocorticoid regulated kinase 1 | IL-2 induced regulation of Sgk1 and a role of the IL-2 receptor and Sgk1 in the regulation of epithelial tumor cell death and survival | Human | CCL17 | 6361 | chemokine (C-C motif) ligand 17 | In a lung epithelial tumor cell model, respiratory syncytial virus induces the chemokine TARC that has a potential to recruit T helper type 2 (Th2) cells to the lung | Human | NOTCH1 | 4851 | notch 1 | Notch1 intracellular domain positive products were observed in the cells at the peripheral layer of most proliferating epithelial tumor nests in mandibular ameloblastoma | Human | NMT1 | 4836 | N-myristoyltransferase 1 | Based on our previous findings of elevated N-myristoyltransferase (NMT) activity in colonic epithelial neoplasms that appears at an early stage in colonic carcinogenesis, together with elevated NMT expression in human colorectal and gallbladder carcinomas, we investigated NMT activity and protein expression of NMT1 and NMT2 in human brain tumors and documented elevated NMT activity and higher protein expressions. Earlier, we demonstrated that NMT is more active in colonic epithelial neoplasms than in corresponding normal-appearing colonic tissue. Earlier, we have reported that N-myristoyltransferase (NMT) activity is higher in colonic epithelial neoplasms than in normal appearing colonic tissue and that increase in NMT activity appears at an early stage in colonic carcinogenesis [Magnuson, B., Raju, R. V. S., Moyana, T. N., and Sharma, R. K. Previously, we reported that NMT activity is higher in colonic epithelial neoplasms than in normal-appearing colonic tissue and that the increase in NMT activity appears at an early stage in colonic carcinogenesis. | Human | MUC4 | 4585 | mucin 4, cell surface associated | IL-9 modulated MUC4 mucin in airway epithelial tumor cells | Human | MUC1 | 4582 | mucin 1, cell surface associated | Immunity and tumor protection in mice transgenic for human MUC.1, a glycoprotein expressed in the majority of epithelial tumors in humans, were induced by vaccination with B lymphocytes genetically programmed to activate MUC.1-specific CD4 T cells The altered dendritic cell differentiation and antigen presentation function induced by soluble sialylated tumor-associated mucin may represent a mechanism by which epithelial tumors can escape immunosurveillance | Human | CD99 | 4267 | CD99 molecule | The presence of aberrant CD20 expression in a cytokeratin-positive epithelial neoplasm and/or the presence of an immature lymphoid population (by demonstration of CD1a, CD2, CD99 and TdT) indicates a thymic epithelial neoplasm. Taken together, CD5 and CD99 (or other immature T-cell markers such as TdT and Cd1a) should be particularly useful in evaluating mediastinal and other biopsy samples of possible thymic epithelial neoplasms and in the subtyping of these tumors. Weak CD99 immunoreactivity was seen in one additional epithelioid smooth muscle tumor, whereas all other mesenchymal and epithelial neoplasms studied for inhibin and CD99 were negative. We investigated CD99 expression in the development of normal ovary and testis as well as in 25 sex cord-stromal tumors (SCSTs), 7 epithelial neoplasms, and 6 germ cell tumors. Thirty uterine mesenchymal neoplasms (five epithelioid or plexiform smooth muscle tumors, three endometrial stromal tumors, two mixed endometrial stromal and smooth muscle tumors, 10 ESTSCLE, five UTROSCT, and five miscellaneous stromal processes) and five epithelial neoplasms were evaluated for expression of CD99 (clone 12E7) and inhibin (clone R1) in formalin-fixed, paraffin-embedded tissue. | Human | MCM6 | 4175 | minichromosome maintenance complex component 6 | It was found that the MCM6 label index (LI) was significantly higher in adamantine epithelioma than squamous papillary tumor, and in both primary tumor subtypes the LIs of tumors with recurrence were higher than those without recurrence | Human | KRT13 | 3860 | keratin 13 | Expression of keratin 13 in human epithelial neoplasms. | Human | KRAS | 3845 | Kirsten rat sarcoma viral oncogene homolog | |
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