Human | LOXL4 | 84171 | lysyl oxidase-like 4 | The data presented in this work might emphasize the involvement of LOXL4 in molecular processes of the genesis or progression of head and neck carcinomas |
Human | COL18A1 | 80781 | collagen, type XVIII, alpha 1 | production in head and neck carcinoma modulated by hsp47 |
Human | TRPM7 | 54822 | transient receptor potential cation channel, subfamily M, member 7 | Transient receptor potential melastatin 7-like current has a role in cell proliferation in human head and neck carcinoma cells |
Human | GPAA1 | 8733 | glycosylphosphatidylinositol anchor attachment 1 | Results show an increased expression level and elevated copy number for GAA1 in head and neck squamous carcinoma, suggesting a role for this GPI anchor subunit in HNSCC |
Human | TP63 | 8626 | tumor protein p63 | p63 and p73 expression may represent an early event in head and neck squamous carcinoma tumorigenesis and may function as oncogenes in the development of these tumors |
Human | TP53 | 7157 | tumor protein p53 | the lack of correlation between p73 or p63 and p53 expression in head and neck squamous carcinoma suggests an independent and/or compensatory functional role |
Human | STAT3 | 6774 | signal transducer and activator of transcription 3 (acute-phase response factor) | Findings provide evidence that STAT 3 signal activity in head and neck carcinomas, which is partially responsible for proliferative activity, can be controlled via the EGFR |
Human | SRC | 6714 | v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog | results indicate that Src and E-cadherin may play an important role in epithelial-mesenchymal transformations, invasion, and aggressive clinicopathologic features of head and neck squamous carcinoma |
Human | SLC2A3 | 6515 | solute carrier family 2 (facilitated glucose transporter), member 3 | GLUT-3 gene expression level was high in head and neck carcinoma (HNCs), and its expression was associated with an increased incidence of lymph node metastasis of HNCs |
Human | SLC2A1 | 6513 | solute carrier family 2 (facilitated glucose transporter), member 1 | GLUT-1 gene expression level and protein expression were correlated with lymph node metastasis, poor survival and clinical stage of head and neck carcinoma |
Human | MTHFR | 4524 | methylenetetrahydrofolate reductase (NAD(P)H) | Data indicate the C677T MTHFR polymorphism does not significantly contribute to the genetic susceptibility to breast and prostate cancer, while show some evidence for possible genetic contribution to the development of head and neck carcinoma |
Human | MMP9 | 4318 | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | Data suggest that MMP-9 has a role in tumor progression of head and neck carcinomas, as well as in estimation of the prognosis of these diseases |
Human | KRT19 | 3880 | keratin 19 | Cyfra 21-1 fragment is a sensitive marker in the diagnosis of distant metastases of head and neck carcinoma |
Human | GSTP1 | 2950 | glutathione S-transferase pi 1 | glutathione S-transferase P1 polymorphism is not solely responsible for reducing GSTPi activity or CDDP resistance in head and neck squamous carcinoma |
Human | CDKN1B | 1027 | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | CDK2 activity was reduced dose-dependently after 24 h of ZD1839 treatment and this effect correlated with increased amount of p27(KIP1) and p21(CIP1/WAF1) associated with CDK2-cyclin-E and CDK2-cyclin-A complexes in head/neck squamous carcinoma cell lines |
Human | CDKN1A | 1026 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | CDK2 activity was reduced dose-dependently after 24 h of ZD1839 treatment and this effect correlated with increased amount of p27(KIP1) and p21(CIP1/WAF1) associated with CDK2-cyclin-E and CDK2-cyclin-A complexes in head/neck squamous carcinoma cell lines |
Human | CDH1 | 999 | cadherin 1, type 1, E-cadherin (epithelial) | results indicate that Src and E-cadherin may play an important role in epithelial-mesenchymal transformations, invasion, and aggressive clinicopathologic features of head and neck squamous carcinoma |
Human | SERPINH1 | 871 | serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) | Modulates the production of the endostatin precursor collagen XVIII in head and neck carcinomas |