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Details
Link-It Detail - Disease - ABC-DLBCL
Debug Stats
  • ### Total Build Time: 43 ms 22.772 KB
  • CONCEPT_NAME gt=3 ms Completed: 2 ms rowSize= 316 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 762 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=0 Completed: 0 ms rowSize= 7 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 15 bytes
  • CONCEPT_RELATIONSHIPS gt=28 ms Completed: 28 ms rowSize= 15.660 KB
  • CONCEPT_GENES gt=7 ms Completed: 7 ms rowSize= 4.846 KB
  • CONCEPT_XREFS gt=3 ms Completed: 3 ms rowSize= 1.144 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
ABC-DLBCL C1333296
Definition (1)
A biologic subset of diffuse large B-cell lymphomas with a unique molecular signature or expression profile. It represents approximately 30% of diffuse large B-cell lymphomas, and is characterized by the expression of CD44, PKCbeta1, Cyclin D2, BCL-2, and IRF4/MUM1 genes. Morphologically, these lymphomas are either centroblastic or immunoblastic (ratio 2:1). Patients with this type of diffuse large B-cell lymphoma are reported to have a less favorable outcome compared to those with a germinal center B-cell expression profile, with a 5-year survival rate of 35% and a median survival of 2 years. -- 2004
Relationships (34)

Relation Types:
diso_​to_​anat : 24
diso_​to_​diso : 10


Relationships:
disease_​has_​associated_​disease : 1
is_​abnormal_​cell_​of_​disease : 6
is_​finding_​of_​disease : 1
is_​normal_​cell_​origin_​of_​disease : 5
is_​normal_​tissue_​origin_​of_​disease : 2
is_​not_​abnormal_​cell_​of_​disease : 3
is_​not_​finding_​of_​disease : 1
is_​not_​molecular_​abnormality_​of_​disease : 1
is_​not_​normal_​cell_​origin_​of_​disease : 4
is_​primary_​anatomic_​site_​of_​disease : 2
may_​be_​abnormal_​cell_​of_​disease : 2
may_​be_​associated_​disease_​of_​disease : 2
may_​be_​finding_​of_​disease : 2
may_​be_​molecular_​abnormality_​of_​disease : 2
Page Size
Current 25
  Page 1 of 2
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_ANATis_normal_cell_origin_of_diseaseimg Activated B-Lymphocyte C1515878
DISO_to_ANATis_abnormal_cell_of_diseaseimg Atypical lymphocyte C0221277
DISO_to_ANATis_not_normal_cell_origin_of_diseaseimg B lymphoblast C1516097
DISO_to_ANATis_normal_cell_origin_of_diseaseimg B-Lymphocytes C0004561
DISO_to_ANATis_not_abnormal_cell_of_diseaseimg Cells, Reed-Sternberg C0085133
DISO_to_ANATis_normal_tissue_origin_of_diseaseimg HEMOLYMPHORETICULAR TISSUE C1512398
DISO_to_ANATis_primary_anatomic_site_of_diseaseimg Hematopoietic and Lymphatic System C1512394
DISO_to_ANATis_normal_cell_origin_of_diseaseimg Hematopoietic and Lymphoid Cell C1512385
DISO_to_ANATis_primary_anatomic_site_of_diseaseimg Lymphatic System C0024235
DISO_to_ANATis_normal_tissue_origin_of_diseaseimg Lymphatic Tissue C0024296
DISO_to_ANATis_normal_cell_origin_of_diseaseimg Lymphocyte C0024264
DISO_to_ANATis_normal_cell_origin_of_diseaseimg Mature B-Cell C1513019
DISO_to_ANATis_not_normal_cell_origin_of_diseaseimg Myeloid Cells C0887899
DISO_to_ANATmay_be_abnormal_cell_of_diseaseimg Neoplastic B-Immunoblast C1513927
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic B-Lymphocyte C1513929
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Cell C0597032
DISO_to_ANATmay_be_abnormal_cell_of_diseaseimg Neoplastic Centroblast C1514006
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Hematopoietic and Lymphoid Cell C1513983
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Large B-Lymphocyte C1513995
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Lymphocyte C1514011
DISO_to_ANATis_not_abnormal_cell_of_diseaseimg Neoplastic T-Lymphocyte and Neoplastic Natural Killer Cell C1514110
DISO_to_ANATis_not_normal_cell_origin_of_diseaseimg Plasma Cells C0032112
DISO_to_ANATis_not_abnormal_cell_of_diseaseimg Plasmablastic Immunoblast C1514146
DISO_to_ANATis_not_normal_cell_origin_of_diseaseimg Thymic B-Lymphocyte C1515428
DISO_to_DISOis_not_molecular_abnormality_of_diseaseimg ALK Kinase Overexpression C1515845
Genes (3)

Species:
human : 3
SpeciesGeneGeneIdGene NameEvidence
HumanREL5966v-rel avian reticuloendotheliosis viral oncogene homolog
img NCI, Score=801, Pubmed Id: 15202524, UMLKSK CUI: C1333296
HumanIKBKB3551inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
img NCI, Score=801, Pubmed Id: 11748286, UMLKSK CUI: C1333296
HumanCHUK1147conserved helix-loop-helix ubiquitous kinase
img NCI, Score=801, Pubmed Id: 15671525, UMLKSK CUI: C1333296
img NCI, Score=801, Pubmed Id: 11748286, UMLKSK CUI: C1333296
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C1333296ABC-DLBCL0self