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Details
Link-It Detail - Disease - Aggressive NK cell leukaemia
Debug Stats
  • ### Total Build Time: 138 ms 23.971 KB
  • CONCEPT_NAME gt=4 ms Completed: 4 ms rowSize= 354 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 528 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=0 Completed: 0 ms rowSize= 7 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 15 bytes
  • CONCEPT_RELATIONSHIPS gt=106 ms Completed: 106 ms rowSize= 14.919 KB
  • CONCEPT_GENES gt=20 ms Completed: 20 ms rowSize= 6.958 KB
  • CONCEPT_XREFS gt=6 ms Completed: 6 ms rowSize= 1.162 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Aggressive NK cell leukaemia C1292777
Definition (1)
A rare, highly aggressive, Epstein-Barr virus-associated leukemia, also known as aggressive NK-cell leukemia/lymphoma; it may represent the leukemic counterpart of nasal type extranodal NK/T-cell lymphomas. It affects primarily teenagers and young adults. It is characterized by the systemic proliferation of NK cells in the peripheral blood, bone marrow, liver, and spleen.
Relationships (41)

Relation Types:
diso_​to_​anat : 22
diso_​to_​diso : 19


Relationships:
is_​abnormal_​cell_​of_​disease : 8
is_​finding_​of_​disease : 1
is_​normal_​cell_​origin_​of_​disease : 5
is_​normal_​tissue_​origin_​of_​disease : 2
is_​not_​abnormal_​cell_​of_​disease : 1
is_​not_​finding_​of_​disease : 2
is_​not_​normal_​cell_​origin_​of_​disease : 3
is_​primary_​anatomic_​site_​of_​disease : 3
may_​be_​associated_​disease_​of_​disease : 4
may_​be_​cytogenetic_​abnormality_​of_​disease : 1
may_​be_​finding_​of_​disease : 11
Page Size
Current 25
  Page 1 of 2
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_ANATis_abnormal_cell_of_diseaseimg Atypical lymphocyte C0221277
DISO_to_ANATis_primary_anatomic_site_of_diseaseimg Bone Marrow C0005953
DISO_to_ANATis_normal_tissue_origin_of_diseaseimg HEMOLYMPHORETICULAR TISSUE C1512398
DISO_to_ANATis_primary_anatomic_site_of_diseaseimg Hematopoietic and Lymphatic System C1512394
DISO_to_ANATis_normal_cell_origin_of_diseaseimg Hematopoietic and Lymphoid Cell C1512385
DISO_to_ANATis_normal_cell_origin_of_diseaseimg Killer Cells, Natural C0022688
DISO_to_ANATis_abnormal_cell_of_diseaseimg Leukemic Cell C1517806
DISO_to_ANATis_abnormal_cell_of_diseaseimg Leukemic Lymphocyte C1517808
DISO_to_ANATis_abnormal_cell_of_diseaseimg Leukemic Natural Killer Cell C1517810
DISO_to_ANATis_primary_anatomic_site_of_diseaseimg Lymphatic System C0024235
DISO_to_ANATis_normal_tissue_origin_of_diseaseimg Lymphatic Tissue C0024296
DISO_to_ANATis_normal_cell_origin_of_diseaseimg Lymphocytes C0024264
DISO_to_ANATis_not_normal_cell_origin_of_diseaseimg Myeloid Cells C0887899
DISO_to_ANATis_not_abnormal_cell_of_diseaseimg Neoplastic B-Lymphocyte C1513929
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Cell C0597032
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Hematopoietic and Lymphoid Cell C1513983
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Lymphocyte C1514011
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic T-Lymphocyte and Neoplastic Natural Killer Cell C1514110
DISO_to_ANATis_normal_cell_origin_of_diseaseimg Peripheral (Post-Thymic) T-Lymphocyte and NK-Cell C1519006
DISO_to_ANATis_not_normal_cell_origin_of_diseaseimg Precursor NK-Cell C1514302
DISO_to_ANATis_not_normal_cell_origin_of_diseaseimg Precursor T-Lymphoblast C1515138
DISO_to_ANATis_normal_cell_origin_of_diseaseimg T-Lymphocyte and NK-Cell C1515139
DISO_to_DISOis_not_finding_of_diseaseimg Acute Clinical Course C1332147
DISO_to_DISOmay_be_finding_of_diseaseimg Aggressive Clinical Course C1332223
DISO_to_DISOmay_be_finding_of_diseaseimg Agranulocytosis C0001824
Genes (6)

Species:
human : 6
SpeciesGeneGeneIdGene NameEvidence
HumanABCB45244ATP-binding cassette, sub-family B (MDR/TAP), member 4
img NCI, Score=801, Pubmed Id: 9150348, UMLKSK CUI: C1292777
HumanKLRD13824killer cell lectin-like receptor subfamily D, member 1
img NCI, Score=801, Pubmed Id: 11722437, UMLKSK CUI: C1292777
HumanCXCR13577chemokine (C-X-C motif) receptor 1
img GENERIF, Score=771, Pubmed Id: 15902300, UMLKSK CUI: C1292777
HumanCCR51234chemokine (C-C motif) receptor 5 (gene/pseudogene)
img GENERIF, Score=1000, Pubmed Id: 15902300, UMLKSK CUI: C1292777
HumanASNS440asparagine synthetase (glutamine-hydrolyzing)
img NCI, Score=801, Pubmed Id: 16156856, UMLKSK CUI: C1292777
HumanFASLG356Fas ligand (TNF superfamily, member 6)
img GENERIF, Score=1000, Pubmed Id: 17123604, UMLKSK CUI: C1292777
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C1292777Aggressive NK cell leukaemia0self