Human | CD24 | 100133941 | CD24 molecule | CD24 mediates apoptosis in precursor-B acute lymphoblastic leukemia cell lines in the pro-B and pre-B stages accompanying activation of multiple caspases |
Human | BLACE | 338436 | B-cell acute lymphoblastic leukemia expressed | BLACE is located in region 7q36 and significant expression of BLACE was detected by RT-PCR in bone marrow samples from B cell acute lymphoblastic leukemia patients |
Human | RCSD1 | 92241 | RCSD domain containing 1 | CapZIP is fused to ABL1 in a t(1;9)(q24;q34)-associated B-cell acute lymphoblastic leukemia |
Human | ZMIZ1 | 57178 | zinc finger, MIZ-type containing 1 | Fusion of ZMIZ1 to ABL1 is associated with a B-cell acute lymphoblastic leukemia with a t(9;10)(q34;q22.3) translocation |
Human | FBXW7 | 55294 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | FBXW7 mutation is associated with adult T-cell and B-cell acute lymphocytic leukemias |
Human | BLNK | 29760 | B-cell linker | 16 of the 34 childhood pre-B acute lymphoblastic leukaemia samples that were tested showed a complete loss or drastic reduction of SLP-65 expression |
Human | IKZF1 | 10320 | IKAROS family zinc finger 1 (Ikaros) | Variable Ikaros isoform expression is associated with precursor-B acute lymphoblastic leukemia |
Human | CHST4 | 10164 | carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4 | N-acetylgluosamine-6-O-sulfotransferase is overexpressed in a subgroup of paediatric precursor-B acute lymphoblastic leukaemia |
Human | TPD52 | 7163 | tumor protein D52 | While D52 transcript was detected in T-ALL and pre-B ALL at comparable frequencies, D52 was less frequently detected in ALL bone marrow with hyperdiploid karyotypes, compared with samples with normal karyotypes |
Human | TCF3 | 6929 | transcription factor 3 | Involvement of the TCF3 gene in 19p13 rearrangements and in identifying novel and cryptic TCF3 translocations and also acts as a tumor suppressor gene in b-cell precursor acute lymphoblastic leukemia |
Human | MME | 4311 | membrane metallo-endopeptidase | data identify CD10- cytoplasmic immunoglobulin-positive pre-B ALL as a rare (2.2%) but distinct immuno-subtype of adult ALL that is characterized by a high MLL rearrangement rate and a worse outcome |
Human | MLL | 4297 | | MLL-AF4 fusion gene rearrangements occurs between chromosome 4 and 11 in pre B-cell lymphoblastic leukemia |
Human | IGH@ | 3492 | | Physical location at the V(H) locus is involved in in different stages of B cell development in b-cell acute lymphoblastic leukemia in children translocation, t(6;14)(p22;q32), involving IGH@ as a novel recurrent translocation in 13 b-cell precursor acute lymphoblastic leukemia patients Novel IGH translocations, t(2;14)(q14.3;q2) and t(14;17)(q32;q21), in B-cell precursor acute lymphoblastic leukemia are reported |
Human | ID4 | 3400 | inhibitor of DNA binding 4, dominant negative helix-loop-helix protein | A B-cell lineage acute lymphoblastic leukemia patient with a t(6;14)chromosomal translocation that deregulated ID4 new subgroup of b-cell precursor acute lymphoblastic leukemia characterized by ID4 over-expression and CDKN2A and PAX5 deletions |
Human | ETV6 | 2120 | ets variant 6 | One of the chromosome bands most often involved in structural rearrangements in B-cell precursor acute lymphoblastic leukemia novel TEL-AML1 fusion in precursor B acute lymphoblastic leukemia |
Human | EPHA3 | 2042 | EPH receptor A3 | ephrin-A5-induced cell-morphologic changes of EphA3-positive LK63 pre-B acute lymphoblastic leukemia cells |
Human | EFNA5 | 1946 | ephrin-A5 | ephrin-A5-induced cell-morphologic changes of EphA3-positive LK63 pre-B acute lymphoblastic leukemia cells |
Human | CEBPA | 1050 | CCAAT/enhancer binding protein (C/EBP), alpha | CEBPA is activated by juxtaposition to the immunoglobulin gene enhancer upon its rearrangement with the immunoglobulin heavy-chain locus in precursor B-cell acute lymphoblastic leukemia harboring t(14;19)(q32;q13) |
Human | CDKN2B | 1030 | cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) | The variable expression levels of cell-cycle inhibitor genes CDKN2A, CDKN2B, and CDKN1B due to regulatory polymorphisms could indeed influence the risk of childhood pre-B ALL and contribute to carcinogenesis |
Human | CD70 | 970 | CD70 molecule | CD70 not only contributes to the activation of cytotoxic T cells in B cell precursor acute lymphoblastic leukemia but is a critical signal during the expansion phase of the cytotoxic T cell response |
Human | CD19 | 930 | CD19 molecule | Umbiliccal cord blood-derived CD19-specific T cells after cord blood transplantation can reduce the incidence of CD19+ acute B-cell leukemia relapse |
Human | RUNX1 | 861 | runt-related transcription factor 1 | novel TEL-AML1 fusion in precursor B acute lymphoblastic leukemia |
Human | ABL1 | 25 | c-abl oncogene 1, non-receptor tyrosine kinase | CapZIP is fused to ABL1 in a t(1;9)(q24;q34)-associated B-cell acute lymphoblastic leukemia |