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Details
Link-It Detail - Disease - Precursor B-cell lymphoblastic leukemia
Debug Stats
  • ### Total Build Time: 206 ms 45.796 KB
  • CONCEPT_NAME gt=6 ms Completed: 6 ms rowSize= 376 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 556 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=0 Completed: 0 ms rowSize= 7 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 15 bytes
  • CONCEPT_RELATIONSHIPS gt=157 ms Completed: 157 ms rowSize= 16.109 KB
  • CONCEPT_GENES gt=30 ms Completed: 30 ms rowSize= 27.533 KB
  • CONCEPT_XREFS gt=11 ms Completed: 11 ms rowSize= 1.173 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Precursor B-cell lymphoblastic leukemia C1292769
Definition (1)
The most frequent type of acute lymphoblastic leukemia. Approximately 75% of cases occur in children under six years of age. This is a good prognosis leukemia. In the pediatric age group the complete remission rate is approximately 95% and the disease free survival rate is 70%. Approximately 80% of children appear to be cured. In the adult age group the complete remission rate is 60-85%. (WHO, 2001)
Relationships (49)

Relation Types:
diso_​to_​anat : 22
diso_​to_​chem : 1
diso_​to_​diso : 24
diso_​to_​gene : 2


Relationships:
disease_​has_​associated_​disease : 2
gene_​associated_​with_​disease : 2
gene_​product_​malfunction_​associated_​with_​disease : 1
is_​abnormal_​cell_​of_​disease : 9
is_​associated_​anatomic_​site_​of : 1
is_​normal_​cell_​origin_​of_​disease : 5
is_​normal_​tissue_​origin_​of_​disease : 2
is_​not_​abnormal_​cell_​of_​disease : 1
is_​not_​finding_​of_​disease : 2
is_​not_​normal_​cell_​origin_​of_​disease : 2
is_​primary_​anatomic_​site_​of_​disease : 2
isa : 8
may_​be_​associated_​disease_​of_​disease : 1
may_​be_​finding_​of_​disease : 7
may_​be_​molecular_​abnormality_​of_​disease : 4
Page Size
Current 25
  Page 1 of 2
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_ANATis_abnormal_cell_of_diseaseimg Atypical Lymphoblast C0333826
DISO_to_ANATis_abnormal_cell_of_diseaseimg Atypical lymphocyte C0221277
DISO_to_ANATis_normal_cell_origin_of_diseaseimg B lymphoblast C1516097
DISO_to_ANATis_normal_cell_origin_of_diseaseimg B-Lymphocytes C0004561
DISO_to_ANATis_primary_anatomic_site_of_diseaseimg Bone Marrow C0005953
DISO_to_ANATis_normal_tissue_origin_of_diseaseimg HEMOLYMPHORETICULAR TISSUE C1512398
DISO_to_ANATis_associated_anatomic_site_ofimg Hematopoietic and Lymphatic System C1512394
DISO_to_ANATis_normal_cell_origin_of_diseaseimg Hematopoietic and Lymphoid Cell C1512385
DISO_to_ANATis_abnormal_cell_of_diseaseimg Leukemic Cell C1517806
DISO_to_ANATis_abnormal_cell_of_diseaseimg Leukemic Lymphocyte C1517808
DISO_to_ANATis_primary_anatomic_site_of_diseaseimg Lymphatic System C0024235
DISO_to_ANATis_normal_tissue_origin_of_diseaseimg Lymphatic Tissue C0024296
DISO_to_ANATis_normal_cell_origin_of_diseaseimg Lymphocyte C0024264
DISO_to_ANATis_not_normal_cell_origin_of_diseaseimg Mature B-Cell C1513019
DISO_to_ANATis_not_normal_cell_origin_of_diseaseimg Myeloid Cells C0887899
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic B-Lymphoblast C1513928
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic B-Lymphocyte C1513929
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Cell C0597032
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Hematopoietic and Lymphoid Cell C1513983
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Lymphocyte C1514011
DISO_to_ANATis_not_abnormal_cell_of_diseaseimg Neoplastic T-Lymphocyte and Neoplastic Natural Killer Cell C1514110
DISO_to_ANATis_normal_cell_origin_of_diseaseimg lymphoblast C0229613
DISO_to_CHEMgene_product_malfunction_associated_with_diseaseimg BCL9 protein, human C0672585
DISO_to_DISOisaimg ALL, adult B cell C0279593
DISO_to_DISOisaimg ALL, childhood B-cell C0279584
Genes (23)

Species:
human : 23
SpeciesGeneGeneIdGene NameEvidence
HumanCD24100133941CD24 molecule
img GENERIF, Score=708, Pubmed Id: 12496407, UMLKSK CUI: C1292769
HumanBLACE338436B-cell acute lymphoblastic leukemia expressed
img GENERIF, Score=780, Pubmed Id: 14667812, UMLKSK CUI: C1292769
HumanRCSD192241RCSD domain containing 1
img GENERIF, Score=947, Pubmed Id: 17541395, UMLKSK CUI: C1292769
HumanZMIZ157178zinc finger, MIZ-type containing 1
img GENERIF, Score=1000, Pubmed Id: 18007576, UMLKSK CUI: C1292769
HumanFBXW755294F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
img GENERIF, Score=991, Pubmed Id: 18485478, UMLKSK CUI: C1292769
HumanBLNK29760B-cell linker
img GENERIF, Score=723, Pubmed Id: 12761551, UMLKSK CUI: C1292769
HumanIKZF110320IKAROS family zinc finger 1 (Ikaros)
img GENERIF, Score=924, Pubmed Id: 19131787, UMLKSK CUI: C1292769
HumanCHST410164carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4
img GENERIF, Score=895, Pubmed Id: 16386360, UMLKSK CUI: C1292769
HumanTPD527163tumor protein D52
img GENERIF, Score=1000, Pubmed Id: 16620967, UMLKSK CUI: C1292769
HumanTCF36929transcription factor 3
img GENERIF, Score=929, Pubmed Id: 17311319, UMLKSK CUI: C1292769
HumanMME4311membrane metallo-endopeptidase
img GENERIF, Score=845, Pubmed Id: 16123216, UMLKSK CUI: C1292769
HumanMLL4297
img GENERIF, Score=937, Pubmed Id: 11943339, UMLKSK CUI: C1292769
HumanIGH@3492
img GENERIF, Score=1000, Pubmed Id: 15010366, UMLKSK CUI: C1292769
img GENERIF, Score=929, Pubmed Id: 18656697, UMLKSK CUI: C1292769
img GENERIF, Score=717, Pubmed Id: 17940204, UMLKSK CUI: C1292769
HumanID43400inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
img GENERIF, Score=735, Pubmed Id: 12969807, UMLKSK CUI: C1292769
img GENERIF, Score=929, Pubmed Id: 17940204, UMLKSK CUI: C1292769
HumanETV62120ets variant 6
img GENERIF, Score=924, Pubmed Id: 16673018, UMLKSK CUI: C1292769
img GENERIF, Score=929, Pubmed Id: 17285576, UMLKSK CUI: C1292769
HumanEPHA32042EPH receptor A3
img GENERIF, Score=707, Pubmed Id: 18385452, UMLKSK CUI: C1292769
HumanEFNA51946ephrin-A5
img GENERIF, Score=707, Pubmed Id: 18385452, UMLKSK CUI: C1292769
HumanCEBPA1050CCAAT/enhancer binding protein (C/EBP), alpha
img GENERIF, Score=723, Pubmed Id: 16873674, UMLKSK CUI: C1292769
HumanCDKN2B1030cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
img GENERIF, Score=923, Pubmed Id: 17008550, UMLKSK CUI: C1292769
HumanCD70970CD70 molecule
img GENERIF, Score=929, Pubmed Id: 19109206, UMLKSK CUI: C1292769
HumanCD19930CD19 molecule
img GENERIF, Score=734, Pubmed Id: 16352804, UMLKSK CUI: C1292769
HumanRUNX1861runt-related transcription factor 1
img GENERIF, Score=924, Pubmed Id: 16673018, UMLKSK CUI: C1292769
HumanABL125c-abl oncogene 1, non-receptor tyrosine kinase
img GENERIF, Score=947, Pubmed Id: 17541395, UMLKSK CUI: C1292769
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C1292769Precursor B-cell lymphoblastic leukemia0self