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CONCEPT_NAME gt=9 ms Completed: 9 ms rowSize= 330 bytes
CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
CONCEPT_DEFINITION gt=1 ms Completed: 1 ms rowSize= 402 bytes
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CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
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CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 14 bytes
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CONCEPT_PARENTS gt=0 Completed: 0 ms rowSize= 7 bytes
CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 15 bytes
CONCEPT_RELATIONSHIPS gt=52 ms Completed: 52 ms rowSize= 13.748 KB
CONCEPT_GENES gt=25 ms Completed: 25 ms rowSize= 23.756 KB
CONCEPT_XREFS gt=9 ms Completed: 9 ms rowSize= 1.150 KB
CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
diso_to_anat : 7
diso_to_diso : 20
associated_with : 1
classifies : 1
is_abnormal_cell_of_disease : 3
is_normal_cell_origin_of_disease : 1
is_normal_tissue_origin_of_disease : 1
is_not_finding_of_disease : 2
is_primary_anatomic_site_of_disease : 2
isa : 15
mapped_to : 1
Bone Marrow C0005953|
HEMOLYMPHORETICULAR TISSUE C1512398|
Hematopoietic and Lymphatic System C1512394|
Hematopoietic and Lymphoid Cell C1512385|
Leukemic Cell C1517806|
Neoplastic Cell C0597032|
Neoplastic Hematopoietic and Lymphoid Cell C1513983|
Acute Clinical Course C1332147|
Aggressive NK cell leukaemia C1292777|
CHRONIC LEUKEMIA C1279296|
Chr leuk uns cl w rmson C0686589|
Chronic Lymphocytic Leukemia C0023434|
Chronic Monocytic Leukemia C0023466|
Chronic eosinophilic leukemia C0346421|
Chronic leukaemia, NOS, without mention of remission C0686588|
Chronic lymphoid leukaemia - category C1531666|
Chronic myeloid leukaemia - category C1531667|
Hairy Cell Leukemia C0023443|
Leukemia, Myelogenous, Chronic, BCR-ABL Positive C0023473|
Leukemia, Myeloid, Chronic-Phase C0023474|
Leukemia, Neutrophilic, Chronic C0023481|
Leukemia, Prolymphocytic C0023486|
human : 15
|Human||TCL1A||8115||T-cell leukemia/lymphoma 1A|
A role for ATM in the development of sporadic T-cell chronic leukemias is supported by the finding of loss of heterozygosity at 11q22-23 and ATM mutations in leukemias carrying TCL-1 rearrangements.
The TCL1 locus on chromosome 14 band q32.1 is frequently involved in the chromosomal translocations and inversions with the T-cell receptor genes observed in several T-cell tumors, including T-prolymphocytic leukemias, acute and chronic leukemias associated with the immunodeficiency syndrome ataxia-telangiectasia, and adult T-cell leukemia.
|Human||TNF||7124||tumor necrosis factor|
Polymorphisms associated with control of gene expression and protein levels were not associated with occurrence of chronic idiopaathic leukemia in adults and were not responsible for the increased cytokines
|Human||TFRC||7037||transferrin receptor (p90, CD71)|
Combined assessments of TfR and Ki-67 expression revealed a Ki-67- TfR- phenotype in 82% of chronic leukemias, compared with 28% of acute type, and a Ki-67+ TfR+ pattern was found in 27% of acute proliferations but not in any case of chronic leukemia.
To estimate the extent of the TRG gamma variable (V) gene repertoire used in human T cell ontogeny, we have analyzed the variety of V gamma gene rearrangements in a large series of T and non-T acute and chronic leukemias.
|Human||SRC||6714||v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog|
Curcumin treatment inhibited v-src gene expression in K562 chronic leukaemia cells
|Human||ABCB4||5244||ATP-binding cassette, sub-family B (MDR/TAP), member 4|
We performed immunocytochemistry to detect mdr1 and mdr3 P-glycoproteins (P-gps) in 81 patients with acute and chronic leukemia, using the mdr1 P-gp-specific monoclonal antibody (MoAb) MRK16, and the mdr3 P-gp-specific MDR3M.
Expression of the MDR1 and MDR3 gene products in acute and chronic leukemias.
In the 27 patients with chronic leukemia (CLL and GLPD), mdr1 and mdr3 P-gp expression did not correlate to exposure to precytotoxic agents, nor did mdr1 P-gp expression correlate to mdr3 P-gp expression.
Of 23 patients with chronic leukemia (CLL and GLPD), 10 (37%) were positive for mdr1 P-gp and 12 (44%) for mdr3 P-gp.
The results of this study may have implications for clinical therapy for acute or chronic leukemias expressing the mdr1 or mdr3 gene, in particular, treatment with combinations of cytotoxic drugs plus agents that reverse multidrug resistance.
It may be speculated that precytotoxic agents induced mdr1 and mdr3 P-gp expression in acute leukemia; however, in chronic leukemia, both P-gps were expressed independently of exposure to precytotoxic agents.
Expression of mdr1 and mdr3 multidrug-resistance genes in human acute and chronic leukemias and association with stimulation of drug accumulation by cyclosporine.
We determined the expression levels of the mdr1 and mdr3 multidrug-resistance genes (also known as PGY1 and PGY3, respectively) in peripheral blood cells from 69 adult patients with acute and chronic leukemias, using an RNase protection assay.
|Human||NPM1||4869||nucleophosmin (nucleolar phosphoprotein B23, numatrin)|
Fusion tyrosine kinases (FTKs) such as BCR/ABL, TEL/ABL, TEL/JAK2, TEL/PDGF beta R, TEL/TRKC(L), and NPM/ALK arise from reciprocal chromosomal translocations and cause acute and chronic leukemias and non-Hodgkin;s lymphoma.
The clinical spectrum of normocytic hypoplastic anemia, leukocytosis, thrombocytopenia, and abnormal blood cell forms led to diagnoses of congenital infection, myelodysplastic syndromes, or chronic leukemia in these patients before recognition of mevalonate kinase deficiency.
In addition to containing the gag, pol, and env genes of the chronic leukemia viruses, the genome of HTLV-I contains a long open reading frame (LOR) located between the 3; end of the envelope gene and the 3; long terminal repeat sequence (LTR).
|Human||JAK2||3717||Janus kinase 2|
Fusion tyrosine kinases (FTKs) such as BCR/ABL, TEL/ABL, TEL/JAK2, TEL/PDGF beta R, TEL/TRKC(L), and NPM/ALK arise from reciprocal chromosomal translocations and cause acute and chronic leukemias and non-Hodgkins lymphoma.
Curcumin treatment inhibited Jak2 mRNA expression in K562 chronic leukaemia cells
To gain insights into the patterns of activation of this gene during hematopoietic differentiation, we have examined HOXA10 expression in CD34+ and CD34- subfractions of normal marrow and normal peripheral blood, as well as samples from patients with a variety of acute and chronic leukemias.
|Human||GATA1||2623||GATA binding protein 1 (globin transcription factor 1)|
findings suggest that GATA1 mutations are not frequent occurrences in the evolution of blast crisis from chronic myeloid leukaemia chronic phase
|Human||FLT3||2322||fms-related tyrosine kinase 3|
Identified FLT3 internal tandem duplication mutations in a subset of human chronic myelonomocytic leukemia
Curcumin treatment inhibited cyclin D1 mRNA expression in K562 chronic leukaemia cells
APOE genotype influences chronic lymhocytic leukemia outcome and response to therapy, it does not alter susceptibility to developing this disease