GATACA

Credits

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Data

Data - ToppGene Sources

The vast majority of all data in Gataca is from ToppGene so its credits cover data sources that are used within Gataca. The primary reason for utilizing the same sources between these applications is to help ensure consistancy between them. ToppGene, and Gataca, uses data from over 20 sources.

For ToppGene Credits, please visit:

ToppGene Links (Credits)

Data - GUDMAP

GUDMAP

The GUDMAP data within Gataca is only availble within the GUDMAP interface:

Gataca's GUDMAP

Data - UMLSKS

UMLSKS website

Software

Software - Solr

Solr website

Software - PrototypeJS

Prototype JS website

Prototype JavaScript framework, version 1.7
(c) 2005-2010 Sam Stephenson
 
Prototype is freely distributable under the terms of an MIT-style license.
For details, see the Prototype web site: http://www.prototypejs.org/

Software - script.aculo.us

Script.aculo.us website

NOTE: Only the effects.js and dragdrop.js modules from Script.aculo.us are being used.

// script.aculo.us scriptaculous.js v1.9.0, Thu Dec 23 16:54:48 -0500 2010

// Copyright (c) 2005-2010 Thomas Fuchs (http://script.aculo.us, http://mir.aculo.us)
//
// Permission is hereby granted, free of charge, to any person obtaining
// a copy of this software and associated documentation files (the
// "Software"), to deal in the Software without restriction, including
// without limitation the rights to use, copy, modify, merge, publish,
// distribute, sublicense, and/or sell copies of the Software, and to
// permit persons to whom the Software is furnished to do so, subject to
// the following conditions:
//
// The above copyright notice and this permission notice shall be
// included in all copies or substantial portions of the Software.
//
// THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND,
// EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF
// MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND
// NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT HOLDERS BE
// LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN ACTION
// OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN CONNECTION
// WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE SOFTWARE.
//
// For details, see the script.aculo.us web site: http://script.aculo.us/

Software - canvasXpress

canvasXpress website

CanvasXpress is a javascript library based on the <canvas> tag implemented in HTML5.

This package is currently being used for the Venn Diagram within SetBuilder. Plans are to utilize it in other areas in the generation of other graphs.

Software - Oracle Enterprise Edition

Oracle website

The data within Gataca is being stored in an Oracle 11g database.

Software - Modernizr

modernizr

modernizr provides simple interfacing to check to see what features are available within the client's browser. This is predomantly used to test for HTML 5 features such as canvas or local storage support.

Software - JQTouch

JQTouch website

JQTouch is being used for the mobile edition of Gataca.

Software - jQuery

JQuery website

jQuery is used within JQTouch only.

Software - tablesort

tablesort website

Copyright (c) 2006 Andrew Tetlaw 
http://tetlaw.id.au/view/blog/table-sorting-with-prototype/

Permission is hereby granted, free of charge, to any person
obtaining a copy of this software and associated documentation
files (the "Software"), to deal in the Software without
restriction, including without limitation the rights to use, copy,
modify, merge, publish, distribute, sublicense, and/or sell copies
of the Software, and to permit persons to whom the Software is
furnished to do so, subject to the following conditions:

The above copyright notice and this permission notice shall be
included in all copies or substantial portions of the Software.

Software - Firebug Light

Firebug Light website

firebugx.js - There is no disclaimer in the original file, but it is an open source project. The main website is http://www.getfirebug.com It is an open source project hosted by Google code.

Link-It Detail - Disease - Mild cognitive disorder

Debug Stats

### Total Build Time: 24 ms 33.932 KB
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CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 1.200 KB
Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
CONCEPT_SEMANTIC_TYPE gt=1 ms Completed: 1 ms rowSize= 14 bytes
Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
CONCEPT_PARENTS gt=0 Completed: 0 ms rowSize= 7 bytes
CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 15 bytes
CONCEPT_RELATIONSHIPS gt=9 ms Completed: 9 ms rowSize= 12.387 KB
CONCEPT_GENES gt=10 ms Completed: 10 ms rowSize= 18.781 KB
CONCEPT_XREFS gt=2 ms Completed: 2 ms rowSize= 1.157 KB
CONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes
Reload Stats

Disease (1)

Mild cognitive disorder C1270972

Definition (1)

Some forgetfulness can be a normal part of aging. However, some people have more memory problems than other people their age. This condition is called mild cognitive impairment, or MCI. People with MCI can take care of themselves and do their normal activities.

MCI memory problems may include

Losing things often
Forgetting to go to events and appointments
Having more trouble coming up with words than other people of the same age

Your healthcare provider can do thinking, memory, and language tests to see if you have MCI. He or she also may suggest that you see a specialist for more tests. Because MCI may be an early sign of Alzheimer's disease, it's really important to see your healthcare provider every 6 to 12 months.

At this time, there is no proven treatment for MCI. Your healthcare provider can check to see if you have any changes in your memory or thinking skills over time.

Relationships (27)

Relation Types:

diso_to_anat : 4

diso_to_chem : 3

diso_to_diso : 11

diso_to_phen : 1

diso_to_phys : 8

Relationships:

none : 23

mapped_to : 1

related_to : 3

Page Size

Current 25

100

250

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Page 1 of 2

Prior Page

Current 1

Relation Type	Co-Occuring Concept Count	Relationship	Concept
DISO_to_DISO	178		Alzheimer Disease C0002395
DISO_to_DISO	76		Complication Aspects C1171258
DISO_to_DISO	52		Dementia C0497327
DISO_to_ANAT	48		Brain C0006104
DISO_to_PHYS	40		Aging C0001811
DISO_to_DISO	34		Amnesia C0002622
DISO_to_PHEN	28		genetic aspects C0017399
DISO_to_DISO	23		Memory Disorders C0025261
DISO_to_PHYS	23		Cognition C0009240
DISO_to_ANAT	21		Hippocampus C0019564
DISO_to_ANAT	21		In Blood C0005768
DISO_to_DISO	18		Parkinson Disease C0030567
DISO_to_DISO	16		Cognition Disorders C0009241
DISO_to_ANAT	15		Cerebral Cortex C0007776
DISO_to_CHEM	15		Amyloid beta-Peptides C0078939
DISO_to_PHYS	15		Autobiographical Memories C0561843
DISO_to_CHEM	13		Fragments, Peptide C0030935
DISO_to_PHYS	13		Executive Control C0935584
DISO_to_PHYS	12		Mental Recall C0034770
DISO_to_DISO	11		Depression C0011570
DISO_to_CHEM	9		Agents, Nootropic C0242913
DISO_to_PHYS	9		Performance, Psychomotor C0033923
DISO_to_PHYS	9		Recognition C0524637
DISO_to_DISO		related_to	Alzheimer Disease C0002395
DISO_to_DISO		related_to	Dementia C0497327

Genes (12)

Species:

human : 12

Species	Gene	GeneId	Gene Name	Evidence
Human	SIGMAR1	10280	sigma non-opioid intracellular receptor 1	GENERIF, Score=1000, Pubmed Id: 17457031, UMLKSK CUI: C1270972 No significant differences were observed for the SIGMAR1 allele, genotype, haplotype, and diplotype distributions between a group of Polish patients with late-onset AD, patients with mild cognitive impairment, and a control group
Human	TP53	7157	tumor protein p53	GENERIF, Score=923, Pubmed Id: 18494939, UMLKSK CUI: C1270972 Elevated levels of pro-apoptotic p53 and its oxidative modification by the lipid peroxidation product, HNE, in brain from subjects with amnestic mild cognitive impairment and Alzheimer's disease are reported
Human	CCL2	6347	chemokine (C-C motif) ligand 2	GENERIF, Score=1000, Pubmed Id: 16307829, UMLKSK CUI: C1270972 Significantly increased MCP-1 levels are found in patients with mild cognitive impairment and in mild Alzheimer's disease (AD), but not in severe AD patients as compared with controls
Human	NOS3	4846	nitric oxide synthase 3 (endothelial cell)	GENERIF, Score=1000, Pubmed Id: 15016421, UMLKSK CUI: C1270972 Subjects with mild cognitive impairment carrying the T allele of the Glu/Asp NOS3 polymorphism perform worse in the Mini-Mental State Examination, Wechsler Memory Scale (Revised) long-term visual memory and the phonetic verbal fluency tests
Human	MAPT	4137	microtubule-associated protein tau	GENERIF, Score=1000, Pubmed Id: 16478530, UMLKSK CUI: C1270972 Shift in the ratio of three-repeat tau and four-repeat tau mRNAs in individual cholinergic basal forebrain neurons in mild cognitive impairment and Alzheimer's disease
Human	HFE	3077	hemochromatosis	GENERIF, Score=1000, Pubmed Id: 15013567, UMLKSK CUI: C1270972 Results of the present study do not implicate the two common HFE mutations (H63D and C282Y) as genetic modifiers of sporadic Alzheimer's disease and mild cognitive impairment
Human	GSK3B	2932	glycogen synthase kinase 3 beta	GENERIF, Score=1000, Pubmed Id: 15555766, UMLKSK CUI: C1270972 Total GSK-3 protein was increased in both Alzheimer's disease and in mild cognitive impairment without a compensatory decrease in activity
Human	CRP	1401	C-reactive protein, pentraxin-related	GENERIF, Score=1000, Pubmed Id: 18841009, UMLKSK CUI: C1270972 patients with Alzheimer's disease showed lower CRP levels than patients with vascular dementia, mild cognitive impairment or depression
Human	CHAT	1103	choline O-acetyltransferase	GENERIF, Score=976, Pubmed Id: 18562794, UMLKSK CUI: C1270972 ChAT 2384 A allele is a risk factor for Alzheimer's disease and mild cognition disorder
Human	BCHE	590	butyrylcholinesterase	GENERIF, Score=1000, Pubmed Id: 18334913, UMLKSK CUI: C1270972 Synergistic effect of apolipoprotein E epsilon4 and butyrylcholinesterase K-variant is associated with disease progression from mild cognitive impairment to Alzheimer's disease
Human	APP	351	amyloid beta (A4) precursor protein	GENERIF, Score=1000, Pubmed Id: 18309230, UMLKSK CUI: C1270972 The amyloid beta peptide pattern in cerebrospinal fluid is able to predict Alzheimer's disease in patients with mild cognitive impairment with a sensitivity of 91% and specificity of 64% GENERIF, Score=717, Pubmed Id: 14676049, UMLKSK CUI: C1270972 Patients who progressed to dementia of Alzheimer type at 2-year follow-up showed significant decrease of baseline platelet APP compared with stable mild cognitive impairment patients and patients who developed other types of dementia
Human	APOE	348	apolipoprotein E	GENERIF, Score=1000, Pubmed Id: 18617739, UMLKSK CUI: C1270972 The presence of the APOE epsilon4 allele is associated with impaired memory functioning in both middle-aged and old subjects with mild cognitive impairment, although the memory function affected varies with age GENERIF, Score=1000, Pubmed Id: 18843182, UMLKSK CUI: C1270972 Our findings support the hypothesis that the ApoE genotype in mild cognitive impairment might be associated with structural changes typically found in the early stages of Alzheimer's disease GENERIF, Score=1000, Pubmed Id: 15804918, UMLKSK CUI: C1270972 possession of an epsilon4 allele does increase risk of Alzheimer's disease in persons with mild cognitive impairment GENERIF, Score=756, Pubmed Id: 18322386, UMLKSK CUI: C1270972 The rate of brain atrophy in certain brain areas may be increased in APOE epsilon 4-positive subjects with mild cognitive impairment progressing to dementia GENERIF, Score=1000, Pubmed Id: 15956169, UMLKSK CUI: C1270972 APOE epsilon 4 carrier status by itself does not predict cognitive decline or conversion to Alzheimer's disease, indicating that APOE genotyping in patients with mild cognitive impairment may have limited clinical applicability for prediction of outcome GENERIF, Score=923, Pubmed Id: 18305286, UMLKSK CUI: C1270972 Traumatic brain injury was not associated with higher rates of amnestic mild cognitive impairment or dementia, and APOE-epsilon4 was not associated with cognition GENERIF, Score=1000, Pubmed Id: 18401171, UMLKSK CUI: C1270972 increased prevalence of APOE epsilon4 in patients with mild cognitive impairment and subjective complaints

XRefs (1)

XRef Types:

cui : 1

ToppGene Datasets:

none : 1

ToppGene Datasets	XRef Type	XRef Id	XRef	Values	Source	Top % Rank
	CUI	C1270972	Mild cognitive disorder	0		self

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