Human | MED25 | 81857 | mediator complex subunit 25 | data suggest that MED25, in cooperation with CBP and Mediators through its distinct domains, imposes a selective advantage on RAR/RXR activation |
Human | PRAME | 23532 | preferentially expressed antigen in melanoma | The overexpression of PRAME protein frequently observed in human cancers confers growth or survival advantages by antagonizing retinoic acid receptor(RAR) signaling |
Human | GJB6 | 10804 | gap junction protein, beta 6, 30kDa | Mutations in connexin 26 and 30 genes are rare in patients with CRS or RARS and do not seem to play a contributory role in the pathogensis of these disorders |
Human | NCOR1 | 9611 | nuclear receptor corepressor 1 | N-CoR functions not merely as a repressor of basal transcription, but rather as a modulator of both basal and ligand-activated transcription of genes controlled by RAR/RXR heterodimers in a dose-dependent manner |
Human | NCOA1 | 8648 | nuclear receptor coactivator 1 | ASXL1 is a novel coactivator of RAR that cooperates with SRC-1 |
Human | SUV39H1 | 6839 | suppressor of variegation 3-9 homolog 1 (Drosophila) | permanent transcriptional silencing is mediated by the association of PML-RAR with chromatin-modifying enzymes and by recruitment of the histone methyltransferase SUV39H1, responsible for trimethylation of lysine 9 of histone H3 |
Human | SOX9 | 6662 | SRY (sex determining region Y)-box 9 | RAR agonists stimulate SOX9 gene expression in breast cancer cell lines: evidence for a role in retinoid-mediated growth inhibition |
Human | RARS | 5917 | arginyl-tRNA synthetase | RARS over-expression impairs aminoacyl t-RNA synthetase interacting multifunctional protein (AIMP1) secretion by both HeLa and MCF7 cells |
Human | RARB | 5915 | retinoic acid receptor, beta | ectopic expression of RAR beta2 is able to down-regulate HPV-18 transcription by selectively abrogating the binding of AP-1 to the viral regulatory region in a ligand-independent manner Hypopharynx tumors showed significantly lower hypermethylation and higher mRNA expression levels of RAR beta2 compared to the tumors located at other sites of the head and neck (RAR)beta functions as a tumor suppressor gene in various contexts where its absence is associated with tumorigenicity and its presence causes cell cycle arrest |
Human | RARA | 5914 | retinoic acid receptor, alpha | Ligand binding to RAR would play a major role in the assembly and intracellular location of a signaling complex involving RAR and the subunits of PI3K ASXL1 is a novel coactivator of RAR that cooperates with SRC-1 permanent transcriptional silencing is mediated by the association of PML-RAR with chromatin-modifying enzymes and by recruitment of the histone methyltransferase SUV39H1, responsible for trimethylation of lysine 9 of histone H3 p21WAF1/CIP1 is a common transcriptional target of retinoid receptors RAR and RXR endocrine molecule retinoic acid, and its receptor RARs play a critical role in alveolarization during the neonatal period of the lung |
Human | PTEN | 5728 | phosphatase and tensin homolog | PPARgamma and RAR play an important role in controlling the growth of leukemia cells via the up-regulation of PTEN |
Human | PPARG | 5468 | peroxisome proliferator-activated receptor gamma | PPARgamma and RAR play an important role in controlling the growth of leukemia cells via the up-regulation of PTEN |
Human | PML | 5371 | promyelocytic leukemia | permanent transcriptional silencing is mediated by the association of PML-RAR with chromatin-modifying enzymes and by recruitment of the histone methyltransferase SUV39H1, responsible for trimethylation of lysine 9 of histone H3 |
Human | MPL | 4352 | myeloproliferative leukemia virus oncogene | no MPL (myeloproliferative leukemia virus oncogene thrombopoietin recept) W515L/K mutations were found in any patients with refractory anemia with ringed sideroblasts associated with marked thrombocytosis (RARS-T) |
Human | JAK2 | 3717 | Janus kinase 2 | RARS-T has a high frequency of the JAK2 V617F mutation JAK2-V617F mutation may have a role in preventing progression of RARS-T (refractory anemia with ringed sideroblasts and marked thrombocytosis) |
Human | ESR2 | 2100 | estrogen receptor 2 (ER beta) | data provide evidence of transcriptional crosstalk between ERbeta and RAR in ERbeta-positive breast cancer cells that are growth inhibited by retinoic acid |
Human | CDKN2B | 1030 | cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) | all RARS patients had a methylated p15(INK4b) promoter correlating with non-detectable expression of this gene in bone marrow cells from those patients |
Human | CDKN1A | 1026 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | p21WAF1/CIP1 is a common transcriptional target of retinoid receptors RAR and RXR |
Human | BMI1 | 648 | BMI1 polycomb ring finger oncogene | Higher positivity rate of Bmi-1 was preferentially seen in refractory anemia with excess blasts (RAEB), RAEB in transformation (RAEB-T), and MDS-AML compared with refractory anemia (RA) and RA with ringed sideroblasts (RARS). |