Genes (28)
Species: human : 28 | |
Human | CCR2 | 729230 | chemokine (C-C motif) receptor 2 | Title:Donor genomics influence graft events: the effectof donor polymorphisms on acute rejection and chronic allograft nephropathy.|Association:Not Found|Conclusion:These data suggest that many of the donor polymorphisms studied in this analysis may influence a recipient's immune response to a renal allograft. However, their greatest impact may be demonstrated in long-term outcomes. | Human | TPMT | 7172 | thiopurine S-methyltransferase | Title:Thiopurine S-methyltransferase genotype predicts azathioprine-induced myelotoxicity in kidney transplant recipients.|Association:Not Found|Conclusion:`Prospective application of pharmacogenetic principles may assist in optimization of immunosuppressive drug therapy and minimize drug toxicities. | Human | TNF | 7124 | tumor necrosis factor | Title:Cytokine gene polymorphism in sensitized kidney transplant recipients and its association with acute rejection episodes|Association:Y|Conclusion:TNF-alpha and IL-10 gene polymorphism may significantly influence the incidence of acute rejection episodes in sensitized kidney transplants, for whom determination of TNF-alpha and IL-10 genotype might help design feasible immunosuppressive protocols. Title:Combined analysis of cytokine genotype polymorphism and the level of expression with allograft function in African-American renal transplant patients|Association:Not Found|Conclusion:We concluded that, dual analysis of cytokine genotype and expression levels by peripheral cells may be an important clue to understanding the contribution of the recipient's immune response to an allograft pre- and post-transplantation. Identification of peripheral markers diagnostic of rejection could allow advance anticipation of clinical outcome, and might reduce the need for tissue biopsy. Title:Cytokine polymorphisms do not influence acute rejection in renal transplantation under tacrolimus-based immunosuppression.|Association:Not Found|Conclusion:Cytokine polymorphisms did not influence acute rejection in our study. We conclude that in the modern era of immunosuppression cytokine genotyping is not a significant predictor of acute rejection in renal transplantation. Title:Donor genomics influence graft events: the effectof donor polymorphisms on acute rejection and chronic allograft nephropathy.|Association:Not Found|Conclusion:These data suggest that many of the donor polymorphisms studied in this analysis may influence a recipient's immune response to a renal allograft. However, their greatest impact may be demonstrated in long-term outcomes. Title:Immune Response Gene Polymorphisms in Renal Transplant Recipients|Association:Not Found|Conclusion:The primary analysis demonstrated no significant association between the immune response gene polymorphisms examined and acute renal graft rejection in Caucasian patients receiving triple immunosuppression. Subsidiary analyses suggesting an influence of CD40L and TGFbeta1 genes on graft survival require independent confirmation. | Human | TGFB1 | 7040 | transforming growth factor, beta 1 | Title:Donor genomics influence graft events: the effectof donor polymorphisms on acute rejection and chronic allograft nephropathy.|Association:Not Found|Conclusion:These data suggest that many of the donor polymorphisms studied in this analysis may influence a recipient's immune response to a renal allograft. However, their greatest impact may be demonstrated in long-term outcomes. Title:Immune Response Gene Polymorphisms in Renal Transplant Recipients|Association:Not Found|Conclusion:The primary analysis demonstrated no significant association between the immune response gene polymorphisms examined and acute renal graft rejection in Caucasian patients receiving triple immunosuppression. Subsidiary analyses suggesting an influence of CD40L and TGFbeta1 genes on graft survival require independent confirmation. Title:Combined analysis of cytokine genotype polymorphism and the level of expression with allograft function in African-American renal transplant patients|Association:Not Found|Conclusion:We concluded that, dual analysis of cytokine genotype and expression levels by peripheral cells may be an important clue to understanding the contribution of the recipient's immune response to an allograft pre- and post-transplantation. Identification of peripheral markers diagnostic of rejection could allow advance anticipation of clinical outcome, and might reduce the need for tissue biopsy. Title:Cytokine gene polymorphism in sensitized kidney transplant recipients and its association with acute rejection episodes|Association:Not Found|Conclusion:TNF-alpha and IL-10 gene polymorphism may significantly influence the incidence of acute rejection episodes in sensitized kidney transplants, for whom determination of TNF-alpha and IL-10 genotype might help design feasible immunosuppressive protocols. | Human | PTPRC | 5788 | protein tyrosine phosphatase, receptor type, C | Title:Immune Response Gene Polymorphisms in Renal Transplant Recipients|Association:Not Found|Conclusion:The primary analysis demonstrated no significant association between the immune response gene polymorphisms examined and acute renal graft rejection in Caucasian patients receiving triple immunosuppression. Subsidiary analyses suggesting an influence of CD40L and TGFbeta1 genes on graft survival require independent confirmation. | Human | ABCB1 | 5243 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 | Title:Association of the multidrug resistance-1 gene single-nucleotide polymorphisms with the tacrolimus dose requirements in renal transplant recipients.|Association:Not Found|Conclusion:Genotype monitoring of the MDR1 gene reliably predicts the optimal dose of tacrolimus in renal transplant recipients and may predict the initial daily dose needed by individual patients to obtain Title:Genetic polymorphisms of the CYP3A4, CYP3A5, and MDR-1 genes and pharmacokinetics of the calcineurin inhibitors cyclosporine and tacrolimus.|Association:Not Found|Conclusion:As a group, patients with the CYP3A5*3/*3 genotype require less tacrolimus to reach target predose concentrations compared with CYP3A5*1 allele carriers, whereas CYP3A4*1B carriers require more tacrolimus to reach target trough concentrations compared with CYP3A4*1 homozygotes. Title:The effect of CYP3A5 and MDR1 polymorphic expression on cyclosporine oral disposition in renal transplant patients.|Association:Not Found|Conclusion:Thus, the MDR1 C3435T genotype offers a potential mechanistic basis to explain interracial differences in CsA oral bioavailability. Further studies are needed to explore the relationship between CYP3A5 and MDR1 genotype and phenotype. Title:CYP3A5 and MDR1 genetic polymorphisms and cyclosporine pharmacokinetics after renal transplantation.|Association:Not Found|Conclusion:The presence of the CYP3A5 SNP does not explain the high variability of cyclosporine pharmacokinetics in stable renal transplant patients. Despite the weak association found for the MDR1 C1236T SNP, MDR1 SNPs are unlikely to be useful for cyclosporine dose optimization in clinical practice. Title:ABCB1 C3435T and G2677T/A polymorphism decreased the risk for steroid-induced osteonecrosis of the femoral head after kidney transplantation.|Association:Not Found|Conclusion:An assessment of C3435T and G2677T/A polymorphisms preceding steroid treatment could be useful for predicting the resistance to ONF development. Title:The effect of CYP3A5 and MDR1 (ABCB1) polymorphisms on cyclosporine and tacrolimus dose requirements and trough blood levels in stable renal transplant patients|Association:Not Found|Conclusion:Given the importance of rapidly achieving target blood concentrations after transplantation, further prospective studies should consider the immediate post-graft period and assess the influence of this specific polymorphism. Beside non-genetic factors (e.g. steroids dosing, drugs interactions), CYP3A5 pharmacogenetic testing performed just before transplantation could contribute to a better individualization of immunosuppressive therapy. | Human | MTRR | 4552 | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase | Title:Effects of single-nucleotide polymorphisms in MTHFR and MTRR on mortality and allograft loss in kidney transplant recipients|Association:Not Found|Conclusion:This study does not support the routine use of MTHFR or MTRR genotyping for prognostic evaluation or risk-stratification in kidney transplant recipients. | Human | MTHFR | 4524 | methylenetetrahydrofolate reductase (NAD(P)H) | Title:Association of methylenetetrahydrofolate reductase T677 allele with early development of chronic allograft nephropathy|Association:Y|Conclusion:The MTHFR T677 allele is associated with the presence of CAN in kidney graft biopsies 12 months after transplantation. Title:Methionine synthase reductase MTRR 66A > G has no effect on total homocysteine, folate, and Vitamin B12 concentrations in renal transplant patients.|Association:Not Found|Conclusion:MTRR has no major effect on tHcy, folate, or Vitamin B(12) plasma concentrations in kidney graft recipients. Title:Effects of single-nucleotide polymorphisms in MTHFR and MTRR on mortality and allograft loss in kidney transplant recipients|Association:Not Found|Conclusion:This study does not support the routine use of MTHFR or MTRR genotyping for prognostic evaluation or risk-stratification in kidney transplant recipients. | Human | IL10 | 3586 | interleukin 10 | Title:Cytokine polymorphisms do not influence acute rejection in renal transplantation under tacrolimus-based immunosuppression.|Association:Not Found|Conclusion:Cytokine polymorphisms did not influence acute rejection in our study. We conclude that in the modern era of immunosuppression cytokine genotyping is not a significant predictor of acute rejection in renal transplantation. Title:Cytokine gene polymorphism in sensitized kidney transplant recipients and its association with acute rejection episodes|Association:Y|Conclusion:TNF-alpha and IL-10 gene polymorphism may significantly influence the incidence of acute rejection episodes in sensitized kidney transplants, for whom determination of TNF-alpha and IL-10 genotype might help design feasible immunosuppressive protocols. Title:Donor genomics influence graft events: the effectof donor polymorphisms on acute rejection and chronic allograft nephropathy.|Association:Not Found|Conclusion:These data suggest that many of the donor polymorphisms studied in this analysis may influence a recipient's immune response to a renal allograft. However, their greatest impact may be demonstrated in long-term outcomes. Title:Immune Response Gene Polymorphisms in Renal Transplant Recipients|Association:Not Found|Conclusion:The primary analysis demonstrated no significant association between the immune response gene polymorphisms examined and acute renal graft rejection in Caucasian patients receiving triple immunosuppression. Subsidiary analyses suggesting an influence of CD40L and TGFbeta1 genes on graft survival require independent confirmation. Title:Combined analysis of cytokine genotype polymorphism and the level of expression with allograft function in African-American renal transplant patients|Association:Not Found|Conclusion:We concluded that, dual analysis of cytokine genotype and expression levels by peripheral cells may be an important clue to understanding the contribution of the recipient's immune response to an allograft pre- and post-transplantation. Identification of peripheral markers diagnostic of rejection could allow advance anticipation of clinical outcome, and might reduce the need for tissue biopsy. | Human | IL6 | 3569 | interleukin 6 (interferon, beta 2) | Title:Association of methylenetetrahydrofolate reductase T677 allele with early development of chronic allograft nephropathy|Association:Not Found|Conclusion:The MTHFR T677 allele is associated with the presence of CAN in kidney graft biopsies 12 months after transplantation. Title:Cytokine polymorphisms do not influence acute rejection in renal transplantation under tacrolimus-based immunosuppression.|Association:Not Found|Conclusion:Cytokine polymorphisms did not influence acute rejection in our study. We conclude that in the modern era of immunosuppression cytokine genotyping is not a significant predictor of acute rejection in renal transplantation. Title:Combined analysis of cytokine genotype polymorphism and the level of expression with allograft function in African-American renal transplant patients|Association:Not Found|Conclusion:We concluded that, dual analysis of cytokine genotype and expression levels by peripheral cells may be an important clue to understanding the contribution of the recipient's immune response to an allograft pre- and post-transplantation. Identification of peripheral markers diagnostic of rejection could allow advance anticipation of clinical outcome, and might reduce the need for tissue biopsy. Title:Donor genomics influence graft events: the effectof donor polymorphisms on acute rejection and chronic allograft nephropathy.|Association:Not Found|Conclusion:These data suggest that many of the donor polymorphisms studied in this analysis may influence a recipient's immune response to a renal allograft. However, their greatest impact may be demonstrated in long-term outcomes. Title:Cytokine gene polymorphism in sensitized kidney transplant recipients and its association with acute rejection episodes|Association:Not Found|Conclusion:TNF-alpha and IL-10 gene polymorphism may significantly influence the incidence of acute rejection episodes in sensitized kidney transplants, for whom determination of TNF-alpha and IL-10 genotype might help design feasible immunosuppressive protocols. | Human | IL2 | 3558 | interleukin 2 | Title:Combined analysis of cytokine genotype polymorphism and the level of expression with allograft function in African-American renal transplant patients|Association:Not Found|Conclusion:We concluded that, dual analysis of cytokine genotype and expression levels by peripheral cells may be an important clue to understanding the contribution of the recipient's immune response to an allograft pre- and post-transplantation. Identification of peripheral markers diagnostic of rejection could allow advance anticipation of clinical outcome, and might reduce the need for tissue biopsy. Title:Donor genomics influence graft events: the effectof donor polymorphisms on acute rejection and chronic allograft nephropathy.|Association:Not Found|Conclusion:These data suggest that many of the donor polymorphisms studied in this analysis may influence a recipient's immune response to a renal allograft. However, their greatest impact may be demonstrated in long-term outcomes. | Human | IL1R1 | 3554 | interleukin 1 receptor, type I | Title:Cytokine polymorphisms do not influence acute rejection in renal transplantation under tacrolimus-based immunosuppression.|Association:Not Found|Conclusion:Cytokine polymorphisms did not influence acute rejection in our study. We conclude that in the modern era of immunosuppression cytokine genotyping is not a significant predictor of acute rejection in renal transplantation. | Human | IFNG | 3458 | interferon, gamma | Title:Cytokine gene polymorphism in sensitized kidney transplant recipients and its association with acute rejection episodes|Association:Not Found|Conclusion:TNF-alpha and IL-10 gene polymorphism may significantly influence the incidence of acute rejection episodes in sensitized kidney transplants, for whom determination of TNF-alpha and IL-10 genotype might help design feasible immunosuppressive protocols. Title:Combined analysis of cytokine genotype polymorphism and the level of expression with allograft function in African-American renal transplant patients|Association:Not Found|Conclusion:We concluded that, dual analysis of cytokine genotype and expression levels by peripheral cells may be an important clue to understanding the contribution of the recipient's immune response to an allograft pre- and post-transplantation. Identification of peripheral markers diagnostic of rejection could allow advance anticipation of clinical outcome, and might reduce the need for tissue biopsy. Title:Donor genomics influence graft events: the effectof donor polymorphisms on acute rejection and chronic allograft nephropathy.|Association:Not Found|Conclusion:These data suggest that many of the donor polymorphisms studied in this analysis may influence a recipient's immune response to a renal allograft. However, their greatest impact may be demonstrated in long-term outcomes. Title:Immune Response Gene Polymorphisms in Renal Transplant Recipients|Association:Not Found|Conclusion:The primary analysis demonstrated no significant association between the immune response gene polymorphisms examined and acute renal graft rejection in Caucasian patients receiving triple immunosuppression. Subsidiary analyses suggesting an influence of CD40L and TGFbeta1 genes on graft survival require independent confirmation. | Human | HLA-DRB1 | 3123 | | Title:HLA-A, B, C, DRB1, DQB1 matching heterogeneity in 'favourably matched' kidney recipients|Association:Not Found|Conclusion:Considerable HLA-A, -B, -C, -DR, -DQ matching heterogeneity exists even amongst 'well matched' renal transplant patient groups. Little is known about the effects of combinations of mismatched specificities on graft survival. Thus, further investigation is merited particularly for HLA-C and -DQ mismatching. | Human | HLA-C | 3107 | | Title:HLA-A, B, C, DRB1, DQB1 matching heterogeneity in 'favourably matched' kidney recipients|Association:Not Found|Conclusion:Considerable HLA-A, -B, -C, -DR, -DQ matching heterogeneity exists even amongst 'well matched' renal transplant patient groups. Little is known about the effects of combinations of mismatched specificities on graft survival. Thus, further investigation is merited particularly for HLA-C and -DQ mismatching. | Human | HLA-B | 3106 | | Title:HLA-A, B, C, DRB1, DQB1 matching heterogeneity in 'favourably matched' kidney recipients|Association:Not Found|Conclusion:Considerable HLA-A, -B, -C, -DR, -DQ matching heterogeneity exists even amongst 'well matched' renal transplant patient groups. Little is known about the effects of combinations of mismatched specificities on graft survival. Thus, further investigation is merited particularly for HLA-C and -DQ mismatching. | Human | HLA-A | 3105 | | Title:HLA-A, B, C, DRB1, DQB1 matching heterogeneity in 'favourably matched' kidney recipients|Association:Not Found|Conclusion:Considerable HLA-A, -B, -C, -DR, -DQ matching heterogeneity exists even amongst 'well matched' renal transplant patient groups. Little is known about the effects of combinations of mismatched specificities on graft survival. Thus, further investigation is merited particularly for HLA-C and -DQ mismatching. | Human | GNB3 | 2784 | guanine nucleotide binding protein (G protein), beta polypeptide 3 | Title:G-protein beta-3-subunit and eNOS gene polymorphism in transplant recipients with long-term renal graft function.|Association:Not Found|Conclusion:Our data suggest that these gene polymorphisms have only a minor influence on long-term renal graft function. | Human | DARC | 2532 | Duffy blood group, atypical chemokine receptor | Title:Duffy antigen receptor and genetic susceptibility of African Americans to acute rejection and delayed function|Association:Not Found|Conclusion:The susceptibility of African American recipients to acute rejection and to DGF was not confirmed to be associated with DARC alleles or genotype. Future studies should exclude a potential role of donor-related DARC in transplant outcomes. | Human | FCGR2A | 2212 | Fc fragment of IgG, low affinity IIa, receptor (CD32) | Title:Association of Fc gamma receptor IIA polymorphisms with acute renal-allograft rejection.|Association:Y|Conclusion:These results reveal a significant association between FcgammaRIIA-R/R131 and acute renal-graft rejection, and it is likely that FcgammaRIIA polymorphisms could be useful markers for potential risk of rejection. | Human | CYP3A5 | 1577 | cytochrome P450, family 3, subfamily A, polypeptide 5 | Title:Genetic polymorphisms of the CYP3A4, CYP3A5, and MDR-1 genes and pharmacokinetics of the calcineurin inhibitors cyclosporine and tacrolimus.|Association:Not Found|Conclusion:As a group, patients with the CYP3A5*3/*3 genotype require less tacrolimus to reach target predose concentrations compared with CYP3A5*1 allele carriers, whereas CYP3A4*1B carriers require more tacrolimus to reach target trough concentrations compared with CYP3A4*1 homozygotes. Title:The effect of CYP3A5 and MDR1 (ABCB1) polymorphisms on cyclosporine and tacrolimus dose requirements and trough blood levels in stable renal transplant patients|Association:Not Found|Conclusion:Given the importance of rapidly achieving target blood concentrations after transplantation, further prospective studies should consider the immediate post-graft period and assess the influence of this specific polymorphism. Beside non-genetic factors (e.g. steroids dosing, drugs interactions), CYP3A5 pharmacogenetic testing performed just before transplantation could contribute to a better individualization of immunosuppressive therapy. | Human | CYP3A4 | 1576 | cytochrome P450, family 3, subfamily A, polypeptide 4 | Title:Genetic polymorphisms of the CYP3A4, CYP3A5, and MDR-1 genes and pharmacokinetics of the calcineurin inhibitors cyclosporine and tacrolimus.|Association:Not Found|Conclusion:As a group, patients with the CYP3A5*3/*3 genotype require less tacrolimus to reach target predose concentrations compared with CYP3A5*1 allele carriers, whereas CYP3A4*1B carriers require more tacrolimus to reach target trough concentrations compared with CYP3A4*1 homozygotes. | Human | CYP3A | 1574 | cytochrome P450, family 3, subfamily A | Title:The effect of CYP3A5 and MDR1 polymorphic expression on cyclosporine oral disposition in renal transplant patients.|Association:Not Found|Conclusion:Thus, the MDR1 C3435T genotype offers a potential mechanistic basis to explain interracial differences in CsA oral bioavailability. Further studies are needed to explore the relationship between CYP3A5 and MDR1 genotype and phenotype. Title:The influence of pharmacogenetics on the time to achieve target tacrolimus concentrations after kidney transplantation.|Association:Y|Conclusion:In conclusion, an initial dosing regimen for tacrolimus based on knowledge of the CYP3AP1 genotype and subsequently guided by concentration measurements has the potential to increase the proportion of patients achieving target blood concentrations early after transplantation. Title:Impact of cytochrome p450 3A5 genetic polymorphism on tacrolimus doses and concentration-to-dose ratio in renal transplant recipients.|Association:Y|Conclusion:Determination of CYP3A5 genotype is predictive of the dose of tacrolimus in renal transplant recipients and may help to determine the initial daily dose needed by individual patients for adequate immunosuppression without excess nephrotoxicity. | Human | CTLA4 | 1493 | cytotoxic T-lymphocyte-associated protein 4 | Title:Immune Response Gene Polymorphisms in Renal Transplant Recipients|Association:Not Found|Conclusion:The primary analysis demonstrated no significant association between the immune response gene polymorphisms examined and acute renal graft rejection in Caucasian patients receiving triple immunosuppression. Subsidiary analyses suggesting an influence of CD40L and TGFbeta1 genes on graft survival require independent confirmation. | Human | CCR5 | 1234 | chemokine (C-C motif) receptor 5 (gene/pseudogene) | Title:Donor genomics influence graft events: the effectof donor polymorphisms on acute rejection and chronic allograft nephropathy.|Association:Not Found|Conclusion:These data suggest that many of the donor polymorphisms studied in this analysis may influence a recipient's immune response to a renal allograft. However, their greatest impact may be demonstrated in long-term outcomes. |
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