Human | WNT3A | 89780 | wingless-type MMTV integration site family, member 3A | These results suggest that Wnt responsiveness is a stage-specific phenomenon in B-cell development and that the morphological changes associated with Wnt signaling may play a role in the motility and metastatic potential of myeloma cells |
Human | ARHGAP24 | 83478 | Rho GTPase activating protein 24 | propose that RC-GAP72 affects cellular morphology by targeting activated Cdc42 and Rac1 GTPases to specific subcellular sites, triggering local morphological changes |
Human | GDPD2 | 54857 | glycerophosphodiester phosphodiesterase domain containing 2 | GDE3 is a novel seven-transmembrane protein with a GP-PDE-like extracellular motif expressed during osteoblast differentiation that accelerates the program of osteoblast differentiation and is involved in morphological change of cells |
Human | GADD45G | 10912 | growth arrest and DNA-damage-inducible, gamma | GADD45g induction by androgens requires new protein synthesis; overexpression of GADD45g inhibited cell growth and caused morphological changes in prostate cell lines, arguing that GADD45g is involved in differentiation induced by androgens |
Human | DLC1 | 10395 | deleted in liver cancer 1 | These analyses provide evidence for a possible link between morphological alterations, protein nuclear translocation and proapoptotic and anti-oncogenic activities of DLC1 in lung cancer |
Human | PAK4 | 10298 | p21 protein (Cdc42/Rac)-activated kinase 4 | PAK4 mediates morphological changes through regulation of GEF-H1 |
Human | ARHGEF2 | 9181 | Rho/Rac guanine nucleotide exchange factor (GEF) 2 | PAK4 mediates morphological changes through regulation of GEF-H1 |
Human | SYNJ2 | 8871 | synaptojanin 2 | Since Syn 2 is a phosphatidylinositol 4,5-biphosphatase involved in cell growth and rearrangement of actin filaments, the increased Syn 2 expression may correlate with the hairy cell leukemia etiology or the characteristic morphologic alterations |
Human | TNF | 7124 | tumor necrosis factor | TNF, GM-CSF, and G-CSF induce actin depolymerization and morphological changes through activation of ERK and/or p38 MAPK, and cytokine-induced actin reorganization may affect inhibitory effect of these cytokines on neutrophil chemotaxis |
Human | SNCA | 6622 | synuclein, alpha (non A4 component of amyloid precursor) | study shows aggregated oligomeric alpha-synuclein is internalized by dopaminergic cells & causes detrimental morphological changes prior to cell death; one mechanism by which it mediates cell death is disruption of tubulin polymerization into microtubules |
Human | SMPD1 | 6609 | sphingomyelin phosphodiesterase 1, acid lysosomal | Since cisplatin activates acid sphingomyelinase (ASMase), we investigate the role of the ASMase/ceramide (Cer) pathway in mediating morphological changes in a breast cancer cell line |
Human | RET | 5979 | ret proto-oncogene | RET activation closely parallels the morphological changes, that it is restricted to those areas of the tumor with the cytological alterations and that it is detectable in both mono- and polyclonal tumors |
Human | PSEN1 | 5663 | presenilin 1 | PS1 may be involved in neuritogenesis and morphological change in SH-SY5Y cells, and P117L mutation may linked to Alzheimer's disease by different mechanisms |
Human | SERPINE1 | 5054 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | In cancer cells PAI-1 is able to induce in vitro cell behaviour modifications, morphological changes, and to promote cell migration |
Human | PAEP | 5047 | progestagen-associated endometrial protein | Glycodelin transfection reduces proliferation of endometrial adenocarcinoma cells, induces morphologic changes, and reduces expression of carcinoma- and chemoresistance-associated genes, such as MUC1 and Bcl-XL |
Human | P2RX1 | 5023 | purinergic receptor P2X, ligand-gated ion channel, 1 | early, transient Ca2+ influx via P2X1 receptors can contribute to platelet activation by stimulating a significant morphological change, but does not readily synergise with P2Y12 receptors to support aggregation |
Human | NF1 | 4763 | neurofibromin 1 | NF1 siRNA induces morphological changes, such as excessive actin stress fiber formation, with elevated negative phosphorylation levels of cofilin, which regulates actin cytoskeletal reorganization by depolymerizing and severing actin filaments |
Human | CD46 | 4179 | CD46 molecule, complement regulatory protein | CD46 costimulation induces morphological changes in T cells and activates the MAP Kinase Signaling System |
Human | ITPKA | 3706 | inositol-trisphosphate 3-kinase A | the morphological changes induced by IP3K-A are mediated by non-enzymatic activities of the protein |
Human | HSPB1 | 3315 | heat shock 27kDa protein 1 | Phosphatase inhibitors prevent HSP27 dephosphorylation, destruction of stress fibrils, and morphological changes in endothelial cells during ATP depletion |
Human | FES | 2242 | feline sarcoma oncogene | c-Fes is a regulator of the tubulin cytoskeleton and may contribute to Fes-induced morphological changes in myeloid hematopoietic and neuronal cells |
Human | FASN | 2194 | fatty acid synthase | RNA interference-mediated silencing of this gene attenuates growth and induces morphological changes and apoptosis of prostate cancer cells |
Human | EPHA3 | 2042 | EPH receptor A3 | ephrin-A5-induced cell-morphologic changes of EphA3-positive LK63 pre-B acute lymphoblastic leukemia cells |
Human | EFNA5 | 1946 | ephrin-A5 | ephrin-A5-induced cell-morphologic changes of EphA3-positive LK63 pre-B acute lymphoblastic leukemia cells |
Human | CRP | 1401 | C-reactive protein, pentraxin-related | The purpose of this study was to analyse morphological changes in small blood vessels of the cardiac syndrome x patients with increased CRP levels |