Genes (70)
Species: human : 70 | |
Human | LRRK2 | 120892 | leucine-rich repeat kinase 2 | Secondary motor complications develop in 50% of those on levodopa therapy | Human | VKORC1 | 79001 | vitamin K epoxide reductase complex, subunit 1 | Title:A polymorphism in VKORC1 gene is associated with an inter-individual variability in the dose-anticoagulant effect of warfarin|Association:Y|Conclusion:Genetic variants of the VKORC1 gene locus modulate the mean daily dose of drug prescribed to acquire the target anticoagulation intensity. Title:Cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase (VKORC1) genotypes as determinants of acenocoumarol sensitivity.|Association:Not Found|Conclusion:The simple genotyping of two SNPs, VKORC1-1639G >A or 1173C >T and the CYP2C9*3 polymorphisms, could thus predict a high risk of overdose before initiation of anticoagulation with acenocoumarol, and provide a safer and more individualized anticoagulant therapy. | Human | WNK4 | 65266 | WNK lysine deficient protein kinase 4 | Mutations in the WNK4 gene identified in Japanese hypertensives may contribute to hypertension and progression of hypertensive complications to some extent | Human | MBL3P | 50639 | mannose-binding lectin family member 3, pseudogene | significantly elevated in patients with type 1 diabetes and suggest a possible role of MBL in the pathogenesis of renovascular complications in diabetes | Human | LY96 | 23643 | lymphocyte antigen 96 | innate immune recognition of LTA via LBP, CD14, and TLR-2 represents an important mechanism in the pathogenesis of systemic complications in the course of infectious diseases brought about by Gram-positive pathogens. while TLR-4 and MD-2 are not involved | Human | UTS2 | 10911 | urotensin 2 | urotensin II may have an aetiological role in hypertension and its complications | Human | PRDX6 | 9588 | peroxiredoxin 6 | AOP2 protects hyperglycemia-induced lens epithelial cell apoptosis; this molecule may have the potential to prevent hyperglycemia-mediated complications in diabetes | Human | ADIPOQ | 9370 | adiponectin, C1Q and collagen domain containing | Adiponectin levels may identify people at risk for obesity-related complications and cardiovascular atherosclerotic disease adiponectin DNA sequence variations might play a role in the complications of morbid obesity Elevated levels of ADPN may be pathogenically related to the development of microvascular complications or represent a beneficial counter-regulatory response The elevated adiponectin concentrations observed in subjects with microvascular disease may indicate an altered regulation of this adipocytokine in patients with complications associated with type 1 diabetes | Human | APLN | 8862 | apelin | Dysregulation of apelin might be involved in the mechanism of establishment of overt diabetes mellitus as well as associated atherosclerotic complications | Human | XDH | 7498 | xanthine dehydrogenase | Genetic variations in xanthine dehydrogenase contribute partly to hypertension and its complications, including atherosclerosis and chronic kidney disease | Human | VEGFA | 7422 | vascular endothelial growth factor A | VEGF plays a pivotal role in the retinal microvascular complications of diabetes | Human | TNNT2 | 7139 | troponin T type 2 (cardiac) | Baseline elevation of cTn is relatively common among patients with stable coronary artery disease undergoing percutaneous intervention and is an independent prognostic indicator of ischemic complications | Human | TNF | 7124 | tumor necrosis factor | analysis of the association of NcoI polymorphism within the promoter/enhancer region of TNFalpha and the first intron of TNFbeta encoding gene with toxic complications following sten cell transplantation Title:Interleukin-10 production genotype protects against acute persistent rejection after lung transplantation.|Association:Not Found|Conclusion:In lung transplant recipients, the increased IL-10 production genotype protects against acute persistent rejection when compared with the intermediate or decreased IL-10 production genotypes. The intermediate IL-10 production genotype in lung transplant recipients can be differentiated into 2 haplotype responses, with the GCC/ACC haplotype associated more with acute persistent rejection. In lung transplant recipients, the immunomodulatory effects of IL-6 are differentiated in the G/C and G/G alleles in conjunction with IL-10 haplotypes, with G/C being associated with more acute persistent rejection in conjunction with the IL-10 GCC/ACC haplotype. Future pharmacogenomic models may incorporate these associations with acute persistent rejection in lung transplant recipients to formulate individualized therapeutic regimens. | Human | TGFB1 | 7040 | transforming growth factor, beta 1 | Title:Interleukin-10 production genotype protects against acute persistent rejection after lung transplantation.|Association:Not Found|Conclusion:In lung transplant recipients, the increased IL-10 production genotype protects against acute persistent rejection when compared with the intermediate or decreased IL-10 production genotypes. The intermediate IL-10 production genotype in lung transplant recipients can be differentiated into 2 haplotype responses, with the GCC/ACC haplotype associated more with acute persistent rejection. In lung transplant recipients, the immunomodulatory effects of IL-6 are differentiated in the G/C and G/G alleles in conjunction with IL-10 haplotypes, with G/C being associated with more acute persistent rejection in conjunction with the IL-10 GCC/ACC haplotype. Future pharmacogenomic models may incorporate these associations with acute persistent rejection in lung transplant recipients to formulate individualized therapeutic regimens. | Human | TFPI | 7035 | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | Elevated levels of TF and TFPI in patients with peripheral arterial occlusive disease can be independent risk factor for atherosclerotic complications Title:Genetic factors contribute to bleeding after cardiac surgery.|Association:Y|Conclusion:We identified seven genetic polymorphisms associated with bleeding after cardiac surgery. Genetic factors appear primarily independent of, and explain at least as much variation in bleeding as clinical covariates; combining genetic and clinical factors double our ability to predict bleeding after cardiac surgery. Accounting for genotype may be necessary when stratifying risk of bleeding after cardiac surgery. Plasma TFPI (tissue factor pathway inhibitor) was signigficantly higher in hyperlipidemic diabetics and those with macrovascular complications | Human | TCF7L2 | 6934 | transcription factor 7-like 2 (T-cell specific, HMG-box) | DG10S478 variant seems to have no influence on manifestation of diabetes and the development of microvascular complications | Human | SLC6A3 | 6531 | solute carrier family 6 (neurotransmitter transporter), member 3 | The A9 allele of the DAT gene is involved in vulnerability to alcohol withdrawal complications in women, but these complications differ from those associated with this polymorphism in alcohol-dependent men | Human | SELL | 6402 | selectin L | There was no association between L-Selectin gene polymorphisms and high expression of L-selectin by leukocytes, or the development of complications in Sickle cell disease | Human | SELE | 6401 | selectin E | data are in keeping with the hypothesis that in systemic inflammation altered E-selectin shedding may play a role in arterial damage & implicates this adhesion molecule in atherosclerotic complications in a high-risk condition like end-stage renal disease G-CSF has a role in the induction of E-selectin ligands on myeloid cells, thus providing mechanistic insight into the pathobiology of G-CSF complications | Human | PLAU | 5328 | plasminogen activator, urokinase | The blood concentrations of soluble urokinase-type plasminogen activator (uPAR) and mannan-binding lectin (MBL) are related to the risk of postoperative infectious complications | Human | ABCB1 | 5243 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 | Title:Warfarin sensitivity related to CYP2C9, CYP3A5, ABCB1 (MDR1) and other factors.|Association:Not Found|Conclusion:CYP3A5 did not affect warfarin dosing. An ABCB1 haplotype containing the exon 26 3435T variant was over-represented among low-dose patients. Thirty-six patients with serious bleeding complications had higher prothrombin time international normalised ratios than 189 warfarin-treated patients without serious bleeding, but there were no significant differences in CYP2C9, CYP3A5 or ABCB1 genotypes and allelic variants. Title:Tacrolimus dosing in adult lung transplant patients is related to cytochrome P4503A5 gene polymorphism.|Association:Y|Conclusion:The authors therefore conclude that tacrolimus dosing in adult lung transplant patients is associated with CYP3A5 gene polymorphisms. | Human | SERPINE1 | 5054 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | the 4G/5G insertion/deletion promoter polymorphism, which leads to differences in PAI-1 production, has been demonstrated to affect risk of developing severe complications and dying from sepsis during meningococcal infection and multiple trauma [review] The 4G/4G genotype can increase the risk of thromboembolic neurological complications after cardiac surgery with cardiopulmonary by-pass Recent data in this review suggest that PAI-1 contributes directly to the complications of obesity, including type 2 diabetes, coronary arterial thrombi, and may even influence the accumulation of visceral fat | Human | TNFRSF11B | 4982 | tumor necrosis factor receptor superfamily, member 11b | increased levels of OPG in plasma from diabetic patients with microvascular complications indicates that OPG may be involved in the development of vascular dysfunction in diabetes | Human | NPPB | 4879 | natriuretic peptide B | During the first months, a late increase of NT-proBNP value was associated with heart transplant complications, with acute rejection being most frequent | Human | MYH9 | 4627 | myosin, heavy chain 9, non-muscle | subjects with mutations in the motor domain present with severe thrombocytopenia and develop nephritis and deafness before the age of 40, while those with mutations in the tail domain have a much lower risk of complications and higher platelet counts |
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