Genes (156)
Species: human : 151 mouse : 5 | |
Mouse | OGFR | 11054 | opioid growth factor receptor | OGF and OGFr are present in squamous cell carcinoma of the head and neck (SCCHN), and OGF represses the replication of SCCHN in tissue culture. | Mouse | POSTN | 10631 | periostin, osteoblast specific factor | Moreover, periostin-overexpressing cells spontaneously metastasized to cervical lymph nodes and to the lung through their aggressive invasiveness in an orthotopic mouse model of HNSCC. | Mouse | LY6D | 8581 | lymphocyte antigen 6 complex, locus D | Click here to display 6 evidence detail records. | Mouse | CCR7 | 1236 | chemokine (C-C motif) receptor 7 | Expression pattern of chemokine receptor 6 (CCR6) and CCR7 in squamous cell carcinoma of the head and neck identifies a novel metastatic phenotype. | Mouse | CD80 | 941 | CD80 molecule | We previously characterized the expression of CD80 in different murine head and neck squamous cell carcinoma (HNSCC) clones derived following tumor progression in the absence of T cell-mediated immunity in severe combined immunodeficient (SCID) mice. | Human | CTAGE4 | 100128553 | CTAGE family, member 4 | Moreover, cTAGE-1, cTAGE-4, cTAGE-5A, and cTAGE-5B could be detected in most types of tumor tissues and cell lines at variable frequencies, including those of cutaneous T cell lymphoma, melanoma, head and neck squamous cell carcinoma, breast carcinoma, and colon carcinoma. Moreover, cTAGE-1, cTAGE-4, cTAGE-5A, and cTAGE-5B could be detected in most types of tumor tissues and cell lines at variable frequencies, including those of cutaneous T cell lymphoma, melanoma, head and neck squamous cell carcinoma, breast carcinoma, and colon carcinoma. | Human | LOXL4 | 84171 | lysyl oxidase-like 4 | CONCLUSION: The data presented in this work might emphasize the involvement of LOXL4 in molecular processes of the genesis or progression of head and neck carcinomas. | Human | ATAD3B | 83858 | ATPase family, AAA domain containing 3B | In situ hybridization for one marker of unknown function, KIAA1273/TOB3, demonstrated its strong overexpression in head and neck carcinomas, thus making it a likely tumor antigen candidate. | Human | MAGED4B | 81557 | melanoma antigen family D, 4B | CONCLUSIONS: There is high expression of MAGE-1 and MAGE-3 antigens in head and neck squamous cell carcinomas, whereas NY-ESO-1 is not significantly expressed. Identification of NY-ESO-1, MAGE-1, and MAGE-3 in head and neck squamous cell carcinoma. | Human | CTAGE1 | 64693 | cutaneous T-cell lymphoma-associated antigen 1 | Moreover, cTAGE-1, cTAGE-4, cTAGE-5A, and cTAGE-5B could be detected in most types of tumor tissues and cell lines at variable frequencies, including those of cutaneous T cell lymphoma, melanoma, head and neck squamous cell carcinoma, breast carcinoma, and colon carcinoma. | Human | CSMD1 | 64478 | CUB and Sushi multiple domains 1 | Recently, based on a single region of homozygous deletion in head and neck squamous cell carcinomas (HNSCC), a putative TSG, CUB and sushi multiple domains-1 (CSMD1), has been identified. | Human | CCNL1 | 57018 | cyclin L1 | Amplification of Cyclin L1 is associated with lymph node metastases in head and neck squamous cell carcinoma (HNSCC). | Human | ST7L | 54879 | suppression of tumorigenicity 7 like | Because allelic loss or rearrangements of human chromosome 1p13 region are reported in breast cancer, germ cell tumors, squamous cell carcinoma of head and neck, non-small cell lung cancer, gastrointestinal stromal/smooth muscle tumors (GIST), meningioma, melanoma, acute megakaryoblastic leukemia (M7), and Kaposi;s sarcoma, ST7R might be a novel tumor suppressor gene on human chromosome 1p13. | Human | LRP12 | 29967 | low density lipoprotein receptor-related protein 12 | To clarify the role of the ST7 gene in cancer, we scrutinized primary head and neck squamous cell carcinomas, invasive ductal carcinomas of the breast, and adenocarcinomas of the colon. | Human | PPP2R3B | 28227 | protein phosphatase 2, regulatory subunit B'', beta | Murine and human keratinocyte cell lines contained more PP-2A activity than did the murine SCC VII/SF squamous cell carcinoma cells or primary cultures of human head and neck squamous cell carcinoma (HNSCC) cells. The role of protein phosphatase-2A (PP-2A) in regulating the motility and adhesion of human head and neck squamous cell carcinomas (HNSCC) was investigated. | Human | DNAJC2 | 27000 | DnaJ (Hsp40) homolog, subfamily C, member 2 | A putative oncogenic role for MPP11 in head and neck squamous cell cancer. | Human | SULF1 | 23213 | sulfatase 1 | Based on the pilot data showing the loss of HSulf-1 in head and neck squamous cell carcinoma cell lines (SCCHN), we sought to employ SCCHN as a model to define the role of HSulf-1 in the molecular regulation of tumorigenicity. | Human | STAB1 | 23166 | stabilin 1 | Only 8 (22%) of the 36 axillary node-negative breast carcinomas expressed the MR on the intratumoral lymph vessels as compared with 16 (50%) of the 32 node-positive carcinomas (P = 0.017), and all eight head and neck carcinoma patients with regional lymph node metastases at diagnosis had tumors that expressed CLEVER-1 on the intratumoral lymph vessels. | Human | KLRK1 | 22914 | killer cell lectin-like receptor subfamily K, member 1 | Interleukin 2 gene transfer prevents NKG2D suppression and enhances antitumor efficacy in combination with cisplatin for head and neck squamous cell cancer. | Human | OGFR | 11054 | opioid growth factor receptor | These data indicate that the OGF receptor is integral to cell replication of SCCHN, and support treatment modalities that amplify OGFr in order to decrease the growth of these neoplasias Progression of squamous cell carcinoma of the head and neck is associated with down-regulation of the opioid growth factor receptor. The opioid growth factor receptor in human head and neck squamous cell carcinoma. | Human | SPINK5 | 11005 | serine peptidase inhibitor, Kazal type 5 | We showed that LEKTI is a potent inhibitor of a family of serine proteinases involved in extracellular matrix remodeling and its expression is downregulated in head and neck squamous cell carcinomas. | Human | POSTN | 10631 | periostin, osteoblast specific factor | Interestingly, periostin was highly expressed in HNSCCs in comparison with normal tissues, and the level of periostin expression was well correlated with the invasiveness of HNSCC cases. Here, we identified periostin as an invasion-promoting factor in HNSCC by comparing the gene expression profiles between parent HNSCC cells and a highly invasive clone. In summary, these findings suggest that periostin plays an important role in the invasion and anchorage-independent growth of HNSCC. Indeed, periostin overexpression promoted invasion and anchorage-independent growth both in vitro and in vivo in HNSCC cells. | Human | SEMA4D | 10507 | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D | Click here to display 5 evidence detail records. | Human | GNB2L1 | 10399 | guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 | RACK1 and stratifin target DeltaNp63alpha for a proteasome degradation in head and neck squamous cell carcinoma cells upon DNA damage. | Human | DLC1 | 10395 | deleted in liver cancer 1 | DLC1 expression was observed in all 11 HNSCC cell lines tested, thus excluding the possibility of transcriptional silencing of DLC1 by promoter hypermethylation. DLC1 is unlikely to be a primary target for deletions on chromosome arm 8p22 in head and neck squamous cell carcinoma. In order to determine whether inactivation of DLC1 is involved in HNSCC, we have screened tumour cell lines for DLC1 mutations and expression. |
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