Genes (83)
Species: human : 83 | |
Human | MUC5B | 727897 | mucin 5B, oligomeric mucus/gel-forming | MUC1, MUC5B and MUC8, but not MUC2 or MUC5AC, are up-regulated in endometrial adenocarcinomas | Human | DACT2 | 168002 | dishevelled-binding antagonist of beta-catenin 2 | DAPPER2 mRNA was expressed in placenta, genitourinary tract tumor, and endometrial adenocarcinoma. | Human | CD109 | 135228 | CD109 molecule | The result demonstrated that CD109 expression is significantly higher in cervical squamous cell carcinomas than in endometrial adenocarcinomas and normal cervix and endometrium. In the present study CD109 expression in cervical squamous cell carcinoma was compared with that in endometrial adenocarcinoma by reverse transcription polymerase chain reaction (RT-PCR). | Human | MAML2 | 84441 | mastermind-like 2 (Drosophila) | MAM-3 antigens, as detectable with monoclonals 67D11 and 115G3, were not detected in normal endometrial glands, but they were found in the majority of endometrial adenocarcinomas. | Human | INHBE | 83729 | inhibin, beta E | To demonstrate a possible secretion of the proteins, dimeric inhibin A, inhibin B, and activin A were measured in culture medium of normal epithelial or stromal endometrial cells and in uterine washing fluid of healthy women or patients with endometrial adenocarcinoma. In this study, we have examined the effects of activin A on cell proliferation, anticancer drug-induced apoptosis and Fas-mediated apoptosis in 3 differentiated human endometrial adenocarcinoma cell lines, namely HEC-1, HHUA and Ishikawa. It was the purpose of the current study to determine whether activin had similar actions on endometrial cell lines, specifically on a well differentiated estrogen-responsive endometrial adenocarcinoma cell line (ISH) and estrogen-unresponsive cells (HEC-50) obtained from a poorly differentiated endometrial adenocarcinoma. Expression and function of activin receptors in human endometrial adenocarcinoma cells. | Human | CTNNBIP1 | 56998 | catenin, beta interacting protein 1 | There was a direct relationship between tamoxifen exposure and overexpression of beta-catenin oncoprotein in endometrial adenocarcinoma | Human | FOXP3 | 50943 | forkhead box P3 | The correlation between the presence of FOXP3(+) Tregs and high vessel density in endometrial adenocarcinomas suggests a link between immunity, intratumoral angiogenesis and poor prognosis | Human | STOML2 | 30968 | stomatin (EPB72)-like 2 | SLP-2 was overexpressed in endometrial adenocarcinoma compared with their normal counterparts | Human | PRG1 | 23574 | p53-responsive gene 1 | p53 overexpression is strongly related to poor prognostic indicators in endometrial adenocarcinoma | Human | FSTL3 | 10272 | follistatin-like 3 (secreted glycoprotein) | However, whereas follistatin mRNA expression did not differ significantly, FLRG was significantly lower in endometrial adenocarcinoma than in healthy endometrial specimens (P<0.0001). FLRG was weakly immunostained in endometrial adenocarcinoma. In the present study we evaluated the expression of two inhibitory activin A ligands, follistatin and follistatin-related gene (FLRG), in endometrial adenocarcinoma and in age-matched healthy human endometrium. | Human | MSLN | 10232 | mesothelin | On tissue microarrays containing 621 carcinomas derived from the same and additional sites as those profiled by gene expression, mesothelin immunoreactivity was highest in cancers of the ovary (serous papillary, endometrioid, and undifferentiated) and pancreas, with less frequent staining seen in adenocarcinomas of the endometrium, lung, and stomach/esophagus. | Human | C1orf38 | 9473 | | Three breast cancer cell lines (MCF-7, SK-BR-3, MDA-MB-231), three ovarian cancer cell lines (SK-OV-3, OVCAR-3 and BG-1) and the endometrial adenocarcinoma cell line HEC-1-A were treated with interferon gamma and the transcript levels of icb-1 isoforms alpha and beta were assessed by means of semiquantitative real-time RT-PCR. A novel basement membrane-induced gene identified in the human endometrial adenocarcinoma cell line HEC1B. Icb-1 (C1orf38) is a human gene initially described to be involved in in vitro differentiation processes of endometrial adenocarcinoma and leukemia cells. | Human | EBAG9 | 9166 | estrogen receptor binding site associated, antigen, 9 | The relationship between RCAS1 expression and several clinicopathological variables (clinical stage, histology, grade, myometrial invasion, lymph-vascular space invasion, and lymph node metastasis) was also assessed in endometrial adenocarcinoma. CONCLUSION: RCAS1 expression might thus be associated with the malignant transformation and poor differentiation observed in uterine endometrial adenocarcinoma. | Human | ENDOU | 8909 | endonuclease, polyU-specific | PP11 mRNA was not expressed in cytotrophoblast-derived normal placental tissue or endometrium-derived normal cells, but was expressed in syncytiotrophoblast-derived normal placental tissue, and in choriocarcinoma and endometrial adenocarcinoma, suggesting its involvement in carcinogenesis. PP11 mRNA was not expressed in cytotrophoblast-derived normal placental tissue or endometrium-derived normal cells, but was expressed in syncytiotrophoblast-derived normal placental tissue, and in choriocarcinoma and endometrial adenocarcinoma, suggesting its involvement in carcinogenesis. | Human | TRIM25 | 7706 | tripartite motif containing 25 | Here, we investigated the expression of 14-3-3 sigma, hormone receptors, Efp and p53 in 86 cases of endometrial adenocarcinoma and 46 cases of normal or non-neoplastic endometria by means of immunohistochemistry and methylation-specific polymerase chain reaction. 14-3-3 sigma expression inversely correlated with estrogen receptor alpha, progesterone receptor and estrogen-responsive finger protein, and positively correlated with myometrial invasion and lymph node metastasis in endometrial adenocarcinoma | Human | VEGFA | 7422 | vascular endothelial growth factor A | Progestins activate this gene transcription in endometrial adenocarcinoma cells | Human | TRO | 7216 | trophinin | Trophinin mediates apical cell adhesion between two human cell lines, trophoblastic teratocarcinoma and endometrial adenocarcinoma. | Human | CLEC3B | 7123 | C-type lectin domain family 3, member B | Serum tetranectin and CA125 in endometrial adenocarcinoma. | Human | TIMP1 | 7076 | TIMP metallopeptidase inhibitor 1 | METHODS: The effects of TGF-beta 1 on cellular invasiveness, gelatinase activity, and expression of TIMP-1 were examined in 2 endometrial adenocarcinoma cell lines, KLE and Ishikawa. Metalloproteinases and tissue inhibitor of metalloproteinase 1 (TIMP-1) in endometrial flushings from pre- and post-menopausal women and from women with endometrial adenocarcinoma. | Human | THBS2 | 7058 | thrombospondin 2 | Frequent HOXA11 and THBS2 promoter methylation, and a methylator phenotype in endometrial adenocarcinoma. | Human | TGFBR3 | 7049 | transforming growth factor, beta receptor III | The lower inhibin alpha and betaglycan expression in endometrial adenocarcinoma suggests that the inhibin action may be disrupted | Human | SULT1E1 | 6783 | sulfotransferase family 1E, estrogen-preferring, member 1 | Regulation of estrogen sulfotransferase in human endometrial adenocarcinoma cells by progesterone. | Human | RPS6KB1 | 6198 | ribosomal protein S6 kinase, 70kDa, polypeptide 1 | Immunohistochemical analysis of S6K1 and S6K2 expression in endometrial adenocarcinomas. AIM: The aim of this study was to analyze the levels 70 kDa ribosomal protein S6 kinase 1 (S6K1) and 70 kDa ribosomal protein S6 kinase 2 (S6K2) expression and S6 ribosomal protein phosphorylation in endometrial adenocarcinomas. CONCLUSION: Overexpression of S6K1 and S6K2 is a characteristic feature of parenchyma and vessels of endometrial adenocarcinomas. | Human | RB1 | 5925 | retinoblastoma 1 | Title:Alterations of the Rb gene and its association with Ki-ras activation and p53 inactivation in endometrial adenocarcinoma.|Association:Not Found|Conclusion:Not Found | Human | PTGS2 | 5743 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | COX-2 expression is significantly more common in endometrial adenocarcinoma and ovarian serous cystadenocarcinoma, but not in cervical squamous carcinoma, compared with normal tissue |
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