Genes (60)
Species:
human : 54 mouse : 6 | |
| Mouse | TNFRSF1B | 7133 | tumor necrosis factor receptor superfamily, member 1B | Our results in ARDS and CM indicate a specific up-regulation of TNFR2, but not of TNFR1, on lung and brain MVEC, respectively. Moreover, mice genetically deficient for TNFR2 (Tnfr2null) were significantly protected from experimental CM, in contrast to TNFR1-deficient (Tnfr1null) mice, which were as susceptible as wild-type mice. Unexpectedly, the genetic deficiency in TNFR2, but not in TNFR1, conferred protection against CM and its associated mortality. During CM, a significant upregulation of TNF-receptor 2 (TNFR2), but not of TNFR1, was found in brain microvessels of susceptible, but not resistant mice. Mice genetically deficient for TNFR2 (Tnfr2null) were significantly protected from CM, while TNFR1-deficient (Tfnr1null) mice were as susceptible as wild-type mice. | | Mouse | SNAP25 | 6616 | synaptosomal-associated protein, 25kDa | The hyperkinesis is ameliorated by low doses of the psychostimulant D-amphetamine and can be rescued genetically by a transgene encoding SNAP-25, located within the Cm deletion. | | Mouse | PXMP2 | 5827 | peroxisomal membrane protein 2, 22kDa | Using a mouse/hamster radiation hybrid panel, Pxmp2 was localized on mouse chromosome 5 at 59 cM. | | Mouse | ITGAL | 3683 | integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) | When administrated on day 6 after infection, antibody to the leukocyte integrin leukocyte function-antigen-1 (LFA-1) but not antibodies to MAC-1, LECAM-1 (the MEL-14 antigen), alpha 4 integrin or ICAM-1 dramatically reduced the incidence of CM, leading to survival of most mice until the later onset of anemia. | | Mouse | HSP90AA2 | 3324 | heat shock protein 90kDa alpha (cytosolic), class A member 2 | We showed that DES, TAM, CM, MXC, and BPA significantly increased uterine weights and uterine hsp90alpha and grp94 levels. | | Mouse | ERCC5 | 2073 | excision repair cross-complementing rodent repair deficiency, complementation group 5 | The xpg gene was localized at 2.3 cM proximal to the microsatellite locus D1Mit18 on the R-positive B band of mouse chromosome 1. | | Human | PTPRVP | 148713 | protein tyrosine phosphatase, receptor type, V, pseudogene | It is the purpose of this paper to show the concept of noninvasive assessment of cardiomyopathy (CM) in cytostatic treatment, esp. with daunorubicin A (A). | | Human | CTNNBIP1 | 56998 | catenin, beta interacting protein 1 | To solve such a problem, we applied a high-throughput comparative proteome experimental strategy, ICAT approach performed with two-dimensional LC-MS/MS analysis, coupled with combinational usage of different bioinformatics tools, to study the proteome of rat liver mitochondria prepared with traditional centrifugation (CM) or further purified with a Nycodenz gradient (PM). | | Human | LRP12 | 29967 | low density lipoprotein receptor-related protein 12 | To identify whether 7q31 and genetic alterations of ST7 were involved in human esophageal carcinogenesis, we performed LOH mapping of a 5.4 cM region at 7q31-q35 in 43 primary esophageal carcinomas, as well as mutational analyses of the ST7 gene in tumors with LOH in this region. | | Human | EBAG9 | 9166 | estrogen receptor binding site associated, antigen, 9 | Twenty-eight of 29 were T1/T2 stage carcinomas (<5 cm in diameter), whereas one third (21 of 61) of the tumors in which CMYC was increased but EBAG9 was not, were advanced T3-stage tumors (P = 0.0012). | | Human | DLEU2 | 8847 | deleted in lymphocytic leukemia 2 (non-protein coding) | Meiotic mapping of glucokinase executed with heterozygosity of one of the hexokinases indicated that the gene GLK1 defining the structure of glucokinase protein is located on the left arm of chromosome III 24 cM to the left of his4 in the order: leu2--his4--glk1. --Only two of 206 independent glucokinase mutants are nonsense ochre, both of which map at one end of the gene. | | Human | IQGAP1 | 8826 | IQ motif containing GTPase activating protein 1 | Taken together, these results indicate close association of IQGAP1 with localized disruption of cell-cell adhesion during CM and that modulation of CM by cross-talk between signals induced by HGF/SF and cell-ECM interactions also involves IQGAP1-related mechanisms. Moreover, confocal laser microscopic study demonstrated the localization of IQGAP1 at the membranes of the lower portion of migrating cells, where cell-cell adhesion was specifically disrupted during CM. Furthermore, when HGF/SF-induced CM was enhanced with pre-coated extracellular matrix (ECM) components, the level of IQGAP1 in Ecc increased more than that caused by HGF/SF alone. On the contrary, when CM was inhibited by interrupting cell-ECM interaction, the level of IQGAP1 in Ecc did not increase despite HGF/SF stimulation. | | Human | TNFRSF11A | 8792 | tumor necrosis factor receptor superfamily, member 11a, NFKB activator | Our previous linkage studies mapped the gene responsible for FEO to an interval of less than 5 cM between D18S64 and D18S51 on chromosome 18q21.2-21.3 in a large Northern Irish family. | | Human | ADAM9 | 8754 | ADAM metallopeptidase domain 9 | On the basis of the findings that (1) purified preparations of BP-5 protease from U2 cell CM contained ADAM-9, (2) ADAM-9 is produced and secreted in high abundance by various human OB cell types, (3) purified ADAM-9 cleaved BP-5 effectively while it did not cleave other IGFBPs or did so with less potency, and (4) purified ADAM-9 bound to alpha2M, we conclude that ADAM-9 is a BP-5 protease produced by human OBs. | | Human | TOC | 7149 | tylosis with oesophageal cancer | From the genotyping of UK and US tylotic families with a high risk of oesophageal cancer we have previously localized the tylosis-associated cancer susceptibility gene (TOC gene, tylosis oesophageal cancer gene) to a 1 cM region on the long arm of chromosome 17 (Kelsell et al., 1996). | | Human | TNNI3 | 7137 | troponin I type 3 (cardiac) | The cardiac troponin I locus (Tnni3) also mapped to Chr 7, approximately 5-10 cM from the centromere and unlinked to the fast skeletal muscle troponin I locus. | | Human | TNFRSF1B | 7133 | tumor necrosis factor receptor superfamily, member 1B | A significant increase in the expression of TNF-receptor 2 (TNFR2, p75), but not of TNFR1 (p55), was found on brain microvessels at the time of CM in susceptible animals. TNFalpha receptors are upregulated in CM, with TNF receptor 2 (TNFR2) showing a higher upregulation than TNFR1 in vivo; (iv). As in pulmonary MVEC derived from ARDS patients, the only TNFR type found up-regulated in brain microvessels during CM was TNFR2. To identify the factors involved in the protection from CM conferred by the lack of TNFR2, we assessed in both knockout and control mice the serum concentrations of mediators that are critical for the development of CM, as well as the up-regulation of intercellular adhesion molecule-1 (ICAM-1) in the brain microvessels. We therefore investigated the role of TNFR2 in the development of this brain pathology by comparing the incidence of CM in wild-type and TNF receptor knock-out mice. | | Human | TK1 | 7083 | thymidine kinase 1, soluble | Canine loci, GALK1, TK1, GH1, MYL4, THRA1, and RARA constitute a closely linked group near the centromeric end of CFA9, spanning a genetic distance of only 4.7 cM. | | Human | SLC18A2 | 6571 | solute carrier family 18 (vesicular monoamine transporter), member 2 | Neoplastic mast cells in all cases of cutaneous mastocytosis retained their VMAT2 positivity. | | Human | SDHD | 6392 | succinate dehydrogenase complex, subunit D, integral membrane protein | Alleles were identical for six contiguous markers, spanning a genetic distance of 6 cM and containing PGL1. | | Human | SAA1 | 6288 | serum amyloid A1 | These data indicate that the appearance of SAA and SIA in CM is not related to their presence or titer in blood serum and that the PCT is a reliable screening method when sperm antibodies are suspected to exist in CM and to a lesser extent in serum. SAA and SIA were assayed in the sera of 172 infertile couples and in the CM of the women and 18 control subjects. Stepwise multiple regression analysis indicated that SAA or SIA antibodies in CM and SAA in female serum have a significant negative correlation with endocervical PCT, whereas sperm motility has a positive correlation. The presence and the number of liver spermatozoa in CM collected for PCT;s were found to be significantly related to the existence of SAA and SIA in CM and serum. | | Human | SAA@ | 6287 | serum amyloid A1 cluster | The presence and the number of liver spermatozoa in CM collected for PCT;s were found to be significantly related to the existence of SAA and SIA in CM and serum. SAA and SIA were assayed in the sera of 172 infertile couples and in the CM of the women and 18 control subjects. Stepwise multiple regression analysis indicated that SAA or SIA antibodies in CM and SAA in female serum have a significant negative correlation with endocervical PCT, whereas sperm motility has a positive correlation. These data indicate that the appearance of SAA and SIA in CM is not related to their presence or titer in blood serum and that the PCT is a reliable screening method when sperm antibodies are suspected to exist in CM and to a lesser extent in serum. | | Human | S100P | 6286 | S100 calcium binding protein P | METHODS: We performed pathologic studies, including Fontana-Masson stain and immunostaining for AE1/AE3 and S100P, on a new case of depigmented EMPD manifesting a 4 x 3 cm hypopigmented-depigmented patch on the root of the penis. | | Human | S100A9 | 6280 | S100 calcium binding protein A9 | Here we report that microglial cells--sensitive cellular sensors of threats to the central nervous system--in CM express the myeloid-related proteins MRP8 (S100A8) and MRP14 (S100A9), Ca2+-binding sensor proteins of activated monocytes. | | Human | S100A8 | 6279 | S100 calcium binding protein A8 | Here we report that microglial cells--sensitive cellular sensors of threats to the central nervous system--in CM express the myeloid-related proteins MRP8 (S100A8) and MRP14 (S100A9), Ca2+-binding sensor proteins of activated monocytes. |
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