Human | TNFRSF10A | 8797 | tumor necrosis factor receptor superfamily, member 10a | There is a functional relevance of DR4 expression in ovarian neoplasms,with perhaps a substantial contribution of DR4 hyper-methylation and consequent loss of DR4 expression to ovarian cancer pathogenesis, particularly in premenopausal patients |
Human | VEGFA | 7422 | vascular endothelial growth factor A | Significantly higher level of VEGF in breast tissue of premenopausal women was found |
Human | VDR | 7421 | vitamin D (1,25- dihydroxyvitamin D3) receptor | associations between BsmI-polymorphism of the VDR gene and bone mineral density and bone metabolism in 24 premenopausal (aged 22-45 years) and 69 postmenopausal (aged 48-65 years) Finnish women No evidence that VDR polymorphisms were associated with mammographic breast density among Caucasian premenopausal women of French descent Genetic variation in the vitamin D receptor gene (VDR) is associated with BMD in premenopausal women |
Human | USF1 | 7391 | upstream transcription factor 1 | USF1 GC haplotype is associated with BMI in premenopausal Korean females |
Human | TGFB1 | 7040 | transforming growth factor, beta 1 | TGF-beta 1 polymorphism may modify individual susceptibility to breast cancer in premenopausal Korean women |
Human | SOD2 | 6648 | superoxide dismutase 2, mitochondrial | The MnSOD Ala-9Val polymorphism may contribute to an increase in breast cancer risk in the context of high alcohol consumption, however the polymorphism is not an overall risk factor for breast cancer in this primarily premenopausal population |
Human | SHBG | 6462 | sex hormone-binding globulin | Plasma SHBG level may represent significant predictor of metabolic syndrome in men and premenopausal women Finds variant SHBG Asn allele (Asp327Asn) associated with reduced breast cancer risk in postmenopausal women [OR, 0.73; 95% CI (95% CI), 0.53-0.99], but not in premenopausal women [OR, 1.03; 95% CI, 0.82-1.27) |
Human | PTGS2 | 5743 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | Stromal expression of COX-2 (cyclooxygenase 2), was significantly higher in premenopausal endometrial polyps compared to postmenopausal polyps |
Human | PON1 | 5444 | paraoxonase 1 | In premenopausal women from the Spanish population, the PON1-108C/T polymorphism, and not polycystic ovary syndrome, is an important determinant of serum paraoxonase activity |
Human | PGR | 5241 | progesterone receptor | appears to be uniformly expressed in leiomyomatosis peritonealis disseminata (LPD)nodules from premenopausal and postmenopausal women, supporting the contention that hormones influence the development of LPD in all cases, regardless of menopausal status |
Human | TNFRSF11B | 4982 | tumor necrosis factor receptor superfamily, member 11b | Low serum osteoprotegerin levels in premenopausal infertile women with low bone density |
Human | MTTP | 4547 | microsomal triglyceride transfer protein | Results suggest that MTP -493G --> T polymorphism was associated with bone mineral density (BMD) in premenopausal women, with the TT genotype being related to increased BMD |
Human | MTHFR | 4524 | methylenetetrahydrofolate reductase (NAD(P)H) | Polymorphisms in the MTHFR gene are associated with breast cancer in premenopausal women |
Human | MTHFD1 | 4522 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase | carriers of the MTHFD1-1958A gene allele were more likely to develop choline deficiency on the low-choline diet unless treated with folic acid; premenopausal women carriers showed 15 times increased susceptibility to organ dysfunction on low-choline diet |
Human | MMP9 | 4318 | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | Stromal expression of MMP-9 (matrix metalloproteinase-9) was significantly higher in premenopausal endometrial polyps compared to postmenopausal polyps |
Human | MMP2 | 4313 | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | Stromal expression of MMP-2 (matrix metalloproteinase-2) was significantly higher in premenopausal endometrial polyps compared to postmenopausal polyps |
Human | LTA | 4049 | lymphotoxin alpha | TNF-beta polymorphism may modify individual susceptibility to breast cancer in premenopausal Korean women |
Human | LRP5 | 4041 | low density lipoprotein receptor-related protein 5 | Premenopausal women drove the association as expected from the proposed role of LRP5 in peak bone mass |
Human | LPL | 4023 | lipoprotein lipase | Increased expression after weight loss may contribute to lower plasma ldl cholesterol and triglycerides in obese premenopausal women |
Human | LEPR | 3953 | leptin receptor | study suggests an association between serum leptin concentration and tumor progression; LEPR-109 polymorphism in premenopausal women appears to be associated with obesity and tumor progression |
Human | LEP | 3952 | leptin | Neither nipple aspiration fluid nor serum levels of leptin were associated with premenopausal or postmenopausal breast cancer |
Human | IGFBP3 | 3486 | insulin-like growth factor binding protein 3 | Association between high IGF-I and IGFBP-3 levels and increased risk of breast cancer in premenopausal women |
Human | GC | 2638 | group-specific component (vitamin D binding protein) | No evidence that DBP polymorphisms were associated with mammographic breast density among Caucasian premenopausal women of French descent Circulating 25(OH)D concentrations in premenopausal women are strongly related to DBP polymorphisms |
Human | ESR2 | 2100 | estrogen receptor 2 (ER beta) | The relationship between ESR1 and ESR2 polymorphisms and bone mineral density in women of 4 races/ethnicities who were premenopausal or in early perimenopause is reported ER beta gene polymorphisms are associated with higher bone mineral density in premenopausal women, suggesting that the ER beta gene may have a modulatory role in bone metabolism in young adulthood |
Human | ESR1 | 2099 | estrogen receptor 1 | In premenopausal women, increased number of ESR1 PvuII and XbaI CG alleles was associated with higher baseline hot flash scores compared with those who had other haplotypes (P = .0026) |