Human | MIR137 | 406928 | microRNA 137 | higher induced levels of miR125b and miR137 in rectal cancer are associated with worse response to the therapy |
Human | VDR | 7421 | vitamin D (1,25- dihydroxyvitamin D3) receptor | haplotype analysis that encompasses different domains of the VDR gene might further our understanding of associations between the VDR gene and colon and rectal cancer |
Human | TP53 | 7157 | tumor protein p53 | Co-mutation of p53 and K-ras gene has neither synergic carcinogenesis-promoting effect, nor prognostic effect on rectal cancer TP53 levels were not helpful in identifying patients who would benefit from neoadjuvant treatment of rectal cancer |
Human | TIMP1 | 7076 | TIMP metallopeptidase inhibitor 1 | Title:Association between preoperative plasma levels of t inhibitor of metalloproteinases 1 and rectal cancer patient survival. a validation study.|Association:Not Found|Conclusion:Not Found |
Human | TCF7L2 | 6934 | transcription factor 7-like 2 (T-cell specific, HMG-box) | Novel mutations in exon 4 of hTCF-4 gene were revealed in this study, which might be of importance in the pathogenesis of sporadic rectal cancer patients with high frequency microsatellite instability |
Human | CXCL12 | 6387 | chemokine (C-X-C motif) ligand 12 | G>A functional transition mapping the 3' untranslated region of the CXCL12 gene has been found to be under-represented among rectal cancer patients when compared to colon cancer patients |
Human | PDGFRB | 5159 | platelet-derived growth factor receptor, beta polypeptide | Cetuximab-based chemoradiotherapy increased PDGFRbeta levels in patients with rectal cancer |
Human | MTHFR | 4524 | methylenetetrahydrofolate reductase (NAD(P)H) | folate intake, low methyl donor status, and MTHFR polymorphisms may play independent roles in the etiology of rectal cancer MTHFR 677T-1298A haplotype in genomic DNA has the potential to be a predictive marker of tumor response in rectal cancer patients submitted to preoperative chemoradiotherapy |
Human | MKI67 | 4288 | antigen identified by monoclonal antibody Ki-67 | Ki-67 levels were not helpful in identifying patients who would benefit from neoadjuvant treatment of rectal cancer |
Human | HRAS | 3265 | Harvey rat sarcoma viral oncogene homolog | k-ras may have a role in progression of rectal cancer after resection |
Human | F3 | 2152 | coagulation factor III (thromboplastin, tissue factor) | correlation between tissue factor (TF) expression and hepatic metastasis and prognosis in rectal cancer |
Human | ETV4 | 2118 | ets variant 4 | E1AF is correlated significantly with tumor progression of human rectal cancer and may be an important factor in rectal cancer progression |
Human | EGFR | 1956 | epidermal growth factor receptor | Epidermal growth factor receptor gene polymorphisms have higher risk of pelvic recurrence in patients with rectal cancer treated with chemoradiation EGFR may have a role in recurrence of rectal cancer after radiotherapy and surgery |
Human | CYP2E1 | 1571 | cytochrome P450, family 2, subfamily E, polypeptide 1 | The CYP2E1 c2/c2 genotype increases susceptibility to rectal cancer and the gene-environmental interactions between the CYP2E1 polymorphism and smoking or alcohol drinking exist for colorectal neoplasia in general |
Human | CEACAM5 | 1048 | carcinoembryonic antigen-related cell adhesion molecule 5 | TNM staging, preoperative CEA and CD44v6 were independent prognostic factors for rectal cancer patients with total mesorectal excision |
Human | CASP3 | 836 | caspase 3, apoptosis-related cysteine peptidase | Caspase-3 may have a role in local recurrence in rectal cancer |
Human | BCL2 | 596 | B-cell CLL/lymphoma 2 | Expression of bcl(2) was present in only 5 cases or rectal cancer with the postchemotherapy changes being not significant |
Human | APOE | 348 | apolipoprotein E | No significant associations between apoE genotype and rectal cancer, survival after diagnosis with colorectal cancer, stage of disease at diagnosis or type of tumor mutation |
Human | BIRC5 | 332 | baculoviral IAP repeat containing 5 | Survivin levels were not helpful in identifying patients who would benefit from neoadjuvant treatment of rectal cancer |
Human | APC | 324 | adenomatous polyposis coli | Finds several types of meat may contribute differently to the aetiology of colon and rectal cancer, depending on APC mutation status |