Human | PTP4A3 | 11156 | protein tyrosine phosphatase type IVA, member 3 | Data suggest that the PRL-3 gene is important for colorectal cancer metastasis and provide a new therapeutic target for these intractable lesions Elevated PRL-3 protein expression is associated with colorectal cancer metastasis |
Human | UMPS | 7372 | uridine monophosphate synthetase | expression of OPRT gene and the OPRT/dihydropyrimidine dehydrogenase ratio might be useful as predictive parameters for the efficacy of fluoropyrimidine-based chemotherapy for metastatic colorectal cancer |
Human | UCHL1 | 7345 | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) | Findings indicated that PGP9.5 was less frequently methylated in metastatic colorectal cancer, suggesting that PGP9.5 hypomethylation might play an important role in re-expression of the PGP9.5 gene in colorectal cancer |
Human | TYMS | 7298 | thymidylate synthetase | Gene expression is a predictor for the efficacy of fluoropyrimidine-based chemotherapy for metastatic colorectal cancer Expression predicts the reponse of metastatic colorectal cancer to raltitrexel |
Human | TIMP1 | 7076 | TIMP metallopeptidase inhibitor 1 | Plasma TIMP-1 levels are significantly and independently associated with objective response in patients with metastatic colorectal cancer receiving combination chemotherapy |
Human | TIAM1 | 7074 | T-cell lymphoma invasion and metastasis 1 | Results identify three genes, high-mobility group box1, annexin IV and phosphoglycerate mutase 1 that were associated with Tiam1 and may be involved in colorectal cancer metastasis |
Human | PTGS2 | 5743 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | Polymorphisms in COX-2 and EGFR may be useful independent molecular markers to predict clinical outcome in patients with metastatic colorectal cancer treated with single-agent cetuximab |
Human | NME1 | 4830 | NME/NM23 nucleoside diphosphate kinase 1 | expression of NM 23protein may reflect biological behaviour of the tumour and may appear to be an important factor in development of colorectal cancer metastases |
Human | MMP7 | 4316 | matrix metallopeptidase 7 (matrilysin, uterine) | MMP-7 activity is upregulated in colorectal cancer liver metastases |
Human | LCP1 | 3936 | lymphocyte cytosolic protein 1 (L-plastin) | association of L-plastin overexpression with increased rate of proliferation and invasion, and loss of E-cadherin expression in the SW480 colon cancer cell line indicates that L-plastin plays an important mechanistic role in colorectal cancer metastasis |
Human | KRAS | 3845 | Kirsten rat sarcoma viral oncogene homolog | results confirm the high prognostic value of KRAS mutations on response to cetuximab and survival in metastatic colorectal cancer patients treated with cetuximab KRAS WT status is associated to survival benefit in cetuximab treated metastatic colorectal cancer |
Human | HRAS | 3265 | Harvey rat sarcoma viral oncogene homolog | Presence of K-ras mutations might be associated with lack of response to panitumumab alone and inferior survival in patients with metastatic colorectal cancer |
Human | GSTP1 | 2950 | glutathione S-transferase pi 1 | GSTP1 codon 105 polymorphism may be predictive for the response to irinotecan-based chemotherapy in patients with metastatic colorectal cancer Title:Association between glutathione S-transferase P1 T1 and M1 genetic polymorphism and survival of patients with metastatic colorectal cancer.|Association:Y|Conclusion:The GSTP1 Ile(105)Val polymorphism is associated in a dose-dependent fashion with increased survival of patients with advanced colorectal cancer receiving 5-FU/oxaliplatin chemotherapy. |
Human | GSTM1 | 2944 | glutathione S-transferase mu 1 | Title:Association between glutathione S-transferase P1 T1 and M1 genetic polymorphism and survival of patients with metastatic colorectal cancer.|Association:Y|Conclusion:The GSTP1 Ile(105)Val polymorphism is associated in a dose-dependent fashion with increased survival of patients with advanced colorectal cancer receiving 5-FU/oxaliplatin chemotherapy. |
Human | ERCC2 | 2068 | excision repair cross-complementing rodent repair deficiency, complementation group 2 | The ERCC2 genotype appears as an important predictive factor of the survival of patients treated with oxaliplatin in first-line therapy for metastatic colorectal cancer |
Human | ERBB2 | 2064 | v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 | expression of c-erbB-2 protein may reflect biological behaviour of the tumour and may appear to be an important factor in development of colorectal cancer metastases |
Human | EGFR | 1956 | epidermal growth factor receptor | clinical data suggesting that there could be a subpopulation of metastatic colorectal cancer patients that are more liable to benefit from anti-EGFR monoclonal antibodies--REVIEW |
Human | ABCC2 | 1244 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | ABCC2 genotype is one of the predictors of the variability of irinotecan pharmacokinetics in Japanese patients with metastatic colorectal cancer receiving FOLFIRI |
Human | BRAF | 673 | v-raf murine sarcoma viral oncogene homolog B | Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer |