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Genes (47)
Species:
human : 47 | |
| Human | CDT1 | 81620 | chromatin licensing and DNA replication factor 1 | Cdt1 overexpression contributes to tumorigenecity by causing genomic instability in transgenic p53 knockout mice | | Human | OBFC2B | 79035 | | Cells deficient in hSSB1 exhibit increased radiosensitivity, defective checkpoint activation and enhanced genomic instability coupled with a diminished capacity for DNA repair | | Human | CHFR | 55743 | checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase | A novel role for CHFR regulating chromosome segregation where decreased expression, as seen in cancer cells, contributes to genomic instability by impairing the spindle assembly checkpoint | | Human | VAC14 | 55697 | Vac14 homolog (S. cerevisiae) | Our findings suggest that the HTLV-I Tax oncoprotein targets TAX1BP2 causing genomic instability and aneuploidy | | Human | REV1 | 51455 | REV1, polymerase (DNA directed) | REV1-dependent processes are important determinants of cisplatin-induced genomic instability and the development of resistance | | Human | DMC1 | 11144 | DNA meiotic recombinase 1 | p53 might be involved in homologous recombination and/or checkpoint function by directly binding to DMC1 protein to repress genomic instability in meiotic germ cells | | Human | YWHAG | 7532 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide | our data indicate that 14-3-3gamma may contribute to tumorigenesis by promoting genomic instability | | Human | XRCC1 | 7515 | X-ray repair complementing defective repair in Chinese hamster cells 1 | XRCC1 Arg399Gln polymorphism may genetically modify the development and progression of testicular germ cell tumors through genomic instability XRCC1 is directly involved in the dominant negative activity of a truncated variant of DNA polymerase beta, possibly leading to the genomic instability characteristic of tumor cells | | Human | WRN | 7486 | Werner syndrome, RecQ helicase-like | cells lacking WRN exhibit deletion of telomeres from single sister chromatids;it is proposed that WRN is necessary for efficient replication of G-rich telomeric DNA, preventing telomere dysfunction and consequent genomic instability | | Human | TP53BP1 | 7158 | tumor protein p53 binding protein 1 | analysis of 53BP1 expression can be a useful tool to estimate the level of genomic instability and, simultaneously, the malignant potency of human thyroid tumors | | Human | TP53 | 7157 | tumor protein p53 | The prevalence of MDM2 gene amplifications and single nucleotide polymorphism 309 in 284 colorectal tumors in relation to TP53 mutational status and genomic instability, is analyzed p53 might be involved in homologous recombination and/or checkpoint function by directly binding to DMC1 protein to repress genomic instability in meiotic germ cells genomic instability is an early event that occurs at precancerous stages prior to changes in tumor suppressor genes (p53 and adenomatosis polyposis coli) in Barrett's esophagus-associated tumorigenesis in patients p53-Driven apoptosis limits centrosome amplification and genomic instability downstream of NPM1 phosphorylation Impaired p53 function in tumour stroma might be related to genomic instability and could enable stromal cell survival in the destabilising tumour microenvironment | | Human | TGFBR2 | 7048 | transforming growth factor, beta receptor II (70/80kDa) | Both genomic instability and clonal selection of transforming growth factor beta resistant cells contribute to the high frequency of TGFBR2 mutations in microsatellite unstable colon cancer | | Human | TERT | 7015 | telomerase reverse transcriptase | Both MYC amplification and TERT expression appear to be associated with high genomic instability and proliferation Short and dysfunctional telomeres limit normal stem cell proliferation and predispose for leukemia by selection of stem cells with defective DNA damage responses that are prone to genome instability This study suggests that telomerase can prevent genomic instability caused by Cr (VI), but not by radiation the type of genomic instability in human cells may depend critically on whether they are telomerase-positive or -negative Data show that telomerase activity is required to bypass senescence but is not sufficient to prevent telomere erosion and genomic instability at lower levels of expression Genomic instability is associated with lack of telomerase activation in ovarian cancer | | Human | AURKA | 6790 | aurora kinase A | Breast cancer development is driven by genomic instability associated with variant Aurora-A | | Human | RPA1 | 6117 | replication protein A1, 70kDa | displaced flaps with secondary structure formed during Okazaki fragment maturation can be melted by hRPA and subsequently annealed to a complementary ectopic DNA site, forming recombination intermediates that can lead to genomic instability | | Human | REST | 5978 | RE1-silencing transcription factor | The high levels of REST or its truncated variants found in certain human tumours may contribute to cellular transformation by promoting genomic instability | | Human | RB1 | 5925 | retinoblastoma 1 | Loss of both RB1 tumor suppressor gene alleles initiates quiescent RB1(-/-) retinomas with low level genomic instability and high expression of the senescence-associated proteins p16(INK4a) and p130 Epigenetic inactivation of the RB1 gene as a factor of genomic instability: a possible contribution to etiology of chromosomal mosaicism during human embryo development | | Human | RAD51 | 5888 | RAD51 recombinase | link between elevated Rad51 protein levels, genome instability, and tumor progression | | Human | RAD17 | 5884 | RAD17 homolog (S. pombe) | Loss of hRAD17 expression occurs frequently in HNSCC, is often due to genomic deletion, and may facilitate genomic instability in HNSCC | | Human | PTGS2 | 5743 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | COX2 expression in MCF7 breast cancer cells induced genomic instability, BCL2 expression, and doxorubicin resistance, thus making them significantly more tumorigenic COX-2 expression in MCF10A breast epithelial cells confers a premalignant phenotype that includes enhanced genomic instability and altered cell-cycle regulation | | Human | PTEN | 5728 | phosphatase and tensin homolog | loss of PTEN and subsequent activation of AKT impair CHK1 through phosphorylation, ubiquitination, and reduced nuclear localization to promote genomic instability in tumor cells | | Human | PRDX1 | 5052 | peroxiredoxin 1 | The observation that PrxI is involved in suppressing genome instability and protecting against cell death potentially provides a better understanding of the consequences of PrxI dysfunction in human cells | | Human | NPM1 | 4869 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | p53-Driven apoptosis limits centrosome amplification and genomic instability downstream of NPM1 phosphorylation | | Human | MYC | 4609 | v-myc avian myelocytomatosis viral oncogene homolog | Myc induces nuclear encoded mitochondrial gene expression and mitochondrial biogenesis, thereby directly linking Myc's transcriptional properties to mitochondrial ROS production, promotion of genomic oxidative damage, and genomic instability c-Myc oncoprotein deregulation is associated with overall genomic instability and its levels were a measure of progression in premalignant cervical lesion | | Human | MUTYH | 4595 | mutY homolog (E. coli) | Our results suggest that hMUTYH might be a useful marker of oxidative stress and that oxidative stress and genomic instability are important in the PD disease process |
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