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Genes (341)
Species: human : 330 mouse : 11 | |
Mouse | LATS1 | 9113 | large tumor suppressor kinase 1 | Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction. | Mouse | RNASET2 | 8635 | ribonuclease T2 | Transfection of RNASE6PL cDNA into HEY4 and SG10G ovarian tumor cell lines suppressed tumorigenicity in nude mice. | Mouse | TFRC | 7037 | transferrin receptor (p90, CD71) | Antitumor activity was demonstrated when the immunotoxin directed against the transferrin receptor was administered to nude mice bearing human ovarian tumors. | Mouse | CCL21 | 6366 | chemokine (C-C motif) ligand 21 | We have found evidence of the anti-tumor effects of 3 major lymphocyte-specific chemokines, secondary lymphoid tissue chemokine (SLC), EBI-1-ligand chemokine (ELC) and stromal cell-derived factor (SDF)-1alpha, in murine models (Meth A fibrosarcoma and HM-1 ovarian tumor). | Mouse | MAS1 | 4142 | MAS1 oncogene | Because these upstream sequences were different in at least 5 nude mouse tumors studied, we suppose that another as yet not identified structural alteration in the mas gene of the original ovarian tumor is responsible for the transforming activity of the gene. Varying from 1.8 to 3.5 kb upstream of the coding region of the mas gene, the DNA sequences in the transfectants diverged from those present in the ovarian tumor, as determined by restriction enzyme mapping. | Mouse | INHA | 3623 | inhibin, alpha | females develop ovarian tumors and a cachexia-like wasting syndrome, resembling mice lacking inhibin alpha alone. We previously reported formation of ovarian granulosa cell tumors with 100% penetration in a transgenic mouse model with murine inhibin alpha subunit promoter-driven (inhalpha)/Simian Virus 40 T-antigen (Tag). | Mouse | GRPR | 2925 | gastrin-releasing peptide receptor | A bombesin analogue ([125I]-mIP-bombesin) has been shown to bind with high affinity to GRPr and to localize to intraperitoneal (i.p.) ovarian tumors 2 days after induction of GRPr in an athymic nude mouse model. | Mouse | EPHA2 | 1969 | EPH receptor A2 | In mice with orthotopic ovarian tumors, treatment with combined paclitaxel and IP EphA2-targeting siRNA-DOPC reduced tumor growth by 48-81% compared to paclitaxel/control siRNA-DOPC IP (HeyA8: 0.34 g v 0.66 g; SKOV3ip1: 0.04 v 0.21, p_lt_0.01). | Mouse | DPH1 | 1801 | diphthamide biosynthesis 1 | Ovca1 heterozygous mutant mice are tumor-prone but rarely develop ovarian tumors. | Mouse | AMH | 268 | anti-Mullerian hormone | We show by histologic and molecular analyses that ovarian tumors developing in transgenic mice, obtained by targeted oncogenesis using an anti-Mullerian hormone promoter-SV40 oncogene construct, are of granulosa-cell origin. | Mouse | A2M | 2 | alpha-2-macroglobulin | Human alpha 2-macroglobulin (alpha 2M) was established here as a major serum factor which inhibits the DNA synthesis of a mouse ovarian tumor cell line in culture. | Human | GGT2 | 728441 | gamma-glutamyltransferase 2 | Click here to display 5 evidence detail records. | Human | MAGEA2B | 266740 | melanoma antigen family A, 2B | Expression of MAGE-1, MAGE-2, MAGE-3/-6 and MAGE-4a/-4b genes in ovarian tumors. | Human | SIX5 | 147912 | SIX homeobox 5 | SIX5 expression appears to be restricted to borderline epithelial ovarian tumours and may be a marker of epithelial differentiation in these tumours; thus borderline ovarian tumours may not be part of a continuum of disease between benign and malignant epithelial ovarian tumours. AIMS: To assess the expression of SIX5 (a homeobox gene) mRNA in surface coelomic epithelium, endocervical epithelium, Fallopian tube epithelium, and benign, borderline, and malignant epithelial ovarian tumours. Expression of SIX5 was not shown in benign epithelial ovarian tumours or in any of the malignant epithelial ovarian tumours. In 31 of 37 borderline epithelial ovarian tumours (84%), SIX5 expression was found in the epithelial cells. | Human | E2F7 | 144455 | E2F transcription factor 7 | down-regulation of E2F7 may contribute to mechanisms underlying platinum resistance in ovarian neoplasms | Human | OVCA2 | 124641 | ovarian tumor suppressor candidate 2 | Northern blot analysis reveals that OVCA1 and OVCA2 mRNA were expressed in normal surface epithelial cells of the ovary, but the level of this transcript is significantly reduced or is undetectable in 92% (11/12) of the ovarian tumors and tumor cell lines analyzed. We have previously identified 2 genes, termed OVCA1 and OVCA2, which are located in a small region showing a high frequency of allelic loss in breast and ovarian tumors and share a common exon. | Human | HTRA3 | 94031 | HtrA serine peptidase 3 | In ovarian cancer there is a dramatic decrease of HtrA3 mRNA and protein levels in all ovarian tumor groups; HtrA3 may function as a tumor suppressor | Human | MUC16 | 94025 | mucin 16, cell surface associated | In ovarian metastases from undiagnosed colorectal adenocarcinomas, elevated CA-125 levels and frequent coexpression of cytokeratin 7 are features that can contribute to misclassification of these metastases as primary ovarian neoplasms MUC16-Mesothelin binding is a high affinity, N-glycan dependent interaction that facilitates peritoneal metastasis of ovarian tumors | Human | SLC22A16 | 85413 | solute carrier family 22 (organic cation/carnitine transporter), member 16 | INFERRED, Score=800, UMLKSK CUI: C0919267 | Human | PROK1 | 84432 | prokineticin 1 | INFERRED, Score=800, UMLKSK CUI: C0919267 | Human | INHBE | 83729 | inhibin, beta E | Click here to display 6 evidence detail records. | Human | CLPTM1L | 81037 | CLPTM1-like | A novel gene, CRR9, which was up-regulated in CDDP-resistant ovarian tumor cell line, was associated with apoptosis. | Human | ABTB1 | 80325 | ankyrin repeat and BTB (POZ) domain containing 1 | Expression of six of them (PINK1, EGR2, HCLS1, DUSP1, BPOZ, and NFIL3) was decreased in ovarian tumors compared with corresponding normal tissues. | Human | PINK1 | 65018 | PTEN induced putative kinase 1 | Expression of six of them (PINK1, EGR2, HCLS1, DUSP1, BPOZ, and NFIL3) was decreased in ovarian tumors compared with corresponding normal tissues. | Human | TMPRSS3 | 64699 | transmembrane protease, serine 3 | An ovarian tumor cDNA library was screened, and the entire cDNA of TADG-12 has been identified. |
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