Human | EGLN1 | 54583 | egl-9 family hypoxia-inducible factor 1 | PHD inhibitors preferentially bind to the active site of PHD2 and stabilize HIF activity, induce angiogenesis and protect against cerebral ischemia |
Human | NDUFA13 | 51079 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 | The IFN-beta- and tretinoin-induced GRIM-19 is upregulated during focal cerebral ischemia |
Human | AIFM1 | 9131 | apoptosis-inducing factor, mitochondrion-associated, 1 | Promoting neuronal survival of GDNF might be related to the reduction of AIF nuclear translocation, indicating the high therapeutic potency of SeV/GDNF for cerebral ischemia |
Human | PROZ | 8858 | protein Z, vitamin K-dependent plasma glycoprotein | Title:A common polymorphism of the protein Z gene is associated with protein Z plasma levels and with risk of cerebral ischemia in the young.|Association:Y|Conclusion:The A allele of an intron F polymorphism of the PZ gene appears to be a novel protective genetic marker for the risk of cerebral ischemia in young adults. In the context of juvenile stroke, high PZ plasma levels may represent a prothrombotic condition. |
Human | TLR4 | 7099 | toll-like receptor 4 | The Asp299Gly TLR4-allele might have a protective role in carotid atherosclerosis, but not in cerebral ischemia |
Human | TAC1 | 6863 | tachykinin, precursor 1 | The release of substance P is higher during the first 12 hours after a cerebral ischemia attack, decreasing later but remaining high compared to controls |
Human | PRNP | 5621 | prion protein | study suggests that PrPC has physiological relevance to cerebral ischemic injury and could be useful as a therapeutic target for the treatment of cerebral ischemia |
Human | NFKB1 | 4790 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | Therapeutic potentials of targeting different NF-kappaB dimers to limit cerebral ischemia-associated neurodegeneration.[REVIEW] |
Human | MTHFR | 4524 | methylenetetrahydrofolate reductase (NAD(P)H) | The incidences of both homozygous and heterozygous MTHFR gene mutations in cerebral ischemia (26 and 43%) and in cerebral hemorrhage (25 and 60%) were significantly higher than those in the controls (8 and 25%) |
Human | MMP9 | 4318 | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | Although MMP-9 level predicts parenchymal brain hemorrhages after tPA treatment, no relationship exists with the C-1562T polymorphism, probably because this mutation is not functional in response to cerebral ischemia in vivo |
Human | JAK2 | 3717 | Janus kinase 2 | |
Human | HSPA1B | 3304 | heat shock 70kDa protein 1B | HSP70-2 polymorphism may have a role in development of carotid plaque rupture and cerebral ischaemia in NIDDM patients |
Human | GPX1 | 2876 | glutathione peroxidase 1 | Results indicate that glutathione peroxidase 1-sensitive reactive oxygen species play an important role in regulation of cell death during cerebral ischemia-reperfusion as well as in brain inflammatory reactions |
Human | GABPB1 | 2553 | GA binding protein transcription factor, beta subunit 1 | Results point out that brain-specific angiogenesis inhibitor 2 controls VEGF transcription through GA-binding protein under normal conditions and cerebral ischemia [GA-binding protein gamma] |
Human | F5 | 2153 | coagulation factor V (proaccelerin, labile factor) | the combination of either factor V Leiden or prothrombin G20210A and patent foramen ovale was associated with a 4.7-fold (95% CI=1.4 to 16.1; P=0.008) increased risk of cerebral ischemia in young patients |
Human | F2 | 2147 | coagulation factor II (thrombin) | the combination of either factor V Leiden or prothrombin G20210A and patent foramen ovale was associated with a 4.7-fold (95% CI=1.4 to 16.1; P=0.008) increased risk of cerebral ischemia in young patients prothrombin G20210A mutation is a risk factor in patients with persistent foramen ovale and otherwise unexplained cerebral ischemia |
Human | CREB1 | 1385 | cAMP responsive element binding protein 1 | CREB has a role regulating CRE-mediated gene expression during cerebral ischemia [review] |
Human | CASP3 | 836 | caspase 3, apoptosis-related cysteine peptidase | caspase-3 was upregulated in a region-specific manner with marked activation in the selectively vulnerable hippocampal after cerebral ischemia |
Human | CALM2 | 805 | calmodulin 2 (phosphorylase kinase, delta) | These results suggest that calmodulin plays a crucial role in the processes of Ca(2+)-induced neuronal cell death and the possibility that the blockage of calmodulin attenuates brain injury after cerebral ischemia |
Human | APEX1 | 328 | APEX nuclease (multifunctional DNA repair enzyme) 1 | protective effects of hepatocyte growth factor against cerebral ischemia-induced cell death in the hippocampal CA1 region are related to the improvement of neuronal apex1 |