Human | RASEF | 158158 | RAS and EF-hand domain containing | Homozygosity, in combination with methylation, appears to be the mechanism targeting RASEF in uveal melanoma, and allelic imbalance at this locus supports a TSG role for RASEF |
Human | NIT2 | 56954 | nitrilase family, member 2 | Genotype analysis in 4 types of tumor tissue showed allelic imbalance surrounding NIT2 locus; results show that NIT2 plays an important role in cell growth inhibition & links to malignancies, suggesting Nit2 may be a potential tumor suppressor candidate |
Human | C11orf30 | 56946 | chromosome 11 open reading frame 30 | Data examine possible allelic imbalance in papillary thyroid cancer at EMSY, CAPN5, and PAK1, as candidate genes within 11q13.5-q14 region using a single nucleotide polymorphism-based analysis |
Human | VDR | 7421 | vitamin D (1,25- dihydroxyvitamin D3) receptor | common haplotypic variants within the VDR gene 3'-region previously linked to VDR mRNA expression and allelic imbalance could be associated with HT in the general population, and thus, may be involved in the pathogenesis of HT |
Human | TP53 | 7157 | tumor protein p53 | Results demonstrate that p53 base mutations in combination with allelic imbalance do not predict survival or progression of colorectal cancer Stroma-specific loss of heterozygosity or allelic imbalance is associated with somatic TP53 mutations and regional lymph-node metastases in sporadic breast cancer but not in hereditary breast cancer |
Human | PLAGL1 | 5325 | pleiomorphic adenoma gene-like 1 | Using the ZAC1-specific marker located at 6q24-25, LOH or allelic imbalance was observed |
Human | ABCB1 | 5243 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 | Promoter polymorphisms and allelic imbalance influence ABCB1 mRNA expression |
Human | MMP1 | 4312 | matrix metallopeptidase 1 (interstitial collagenase) | Functional polymorphisms of MMP1 acting in cis is associated with allelic expression imbalance in nornal lung |
Human | SMAD4 | 4089 | SMAD family member 4 | The level of expression of SMAD4 was found to be a more sensitive marker than 18q21 allelic imbalance and SMAD4 mutations, which were of no prognostic significance for colorectal cancer patients |
Human | ERBB2 | 2064 | v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 | The frequency of allelic imbalance was significantly higher (P<0.005) in HER2 amplified (27%) compared to HER2 negative breast tumors (19%) |
Human | EGFR | 1956 | epidermal growth factor receptor | examinination of distributions of three polymorphisms and their relationships to each other and to EGFR gene mutations and allelic imbalance (AI) in non-small cell lung cancers |
Human | CTNNA1 | 1495 | catenin (cadherin-associated protein), alpha 1, 102kDa | Allelic imbalance occurs at two distinct regions of which one includes the CTNNA1 gene in ovarian cancer |
Human | KLF6 | 1316 | Kruppel-like factor 6 | KLF6 allelic imbalance and decreased KLF6 and increased KLF6-SV1 expression are common findings in primary GBM tumors Deregulation of KLF6 by a combination of allelic imbalance and mutation may play a role in the development of colorectal cancer |
Human | BRCA2 | 675 | breast cancer 2, early onset | Allelic imbalance affecting BRCA1 and to a lesser extent BRCA2 may contribute to both familial and non-familial forms of breast cancer |
Human | APC | 324 | adenomatous polyposis coli | results of this study show that esophageal squamous cell carcinoma is associated with genetic instability, that is, allelic imbalance/loss of heterozygosity and microsatellite instability of the APC gene |
Human | APAF1 | 317 | apoptotic peptidase activating factor 1 | Allelic imbalance of 12q22-23 associated with APAF-1 locus correlates with poor disease outcome in cutaneous melanoma |