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Details
Link-It Detail - Disease - DNA Strand Break
Debug Stats
  • ### Total Build Time: 107 ms 21.584 KB
  • CONCEPT_NAME gt=6 ms Completed: 6 ms rowSize= 330 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 345 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=0 Completed: 0 ms rowSize= 7 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 15 bytes
  • CONCEPT_RELATIONSHIPS gt=75 ms Completed: 75 ms rowSize= 11.277 KB
  • CONCEPT_GENES gt=20 ms Completed: 20 ms rowSize= 8.427 KB
  • CONCEPT_XREFS gt=4 ms Completed: 4 ms rowSize= 1.150 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
DNA Strand Break C0872150
Definition (1)
A DNA Strand Break involves one or more disruptions of the covalent linkages among phosphodeoxyribose moieties within the sugar-phosphate backbone in one or in both strands of a DNA molecule.
Relationships (23)

Relation Types:
diso_​to_​anat : 1
diso_​to_​chem : 18
diso_​to_​diso : 3
diso_​to_​phys : 1


Relationships:
biological_​process_​results_​from_​biological_​process : 1
chemical_​or_​drug_​has_​physiologic_​effect : 18
is_​location_​of_​biological_​process : 1
isa : 2
used_​for : 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_ANATis_location_of_biological_processimg Chromosome Structures C0729606
DISO_to_CHEMchemical_or_drug_has_physiologic_effectimg (+)-(4S)-4,11-diethyl-4-hydroxy-9-[(4-piperidino-piperidino)carbonyloxy]-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinol-3,14,(4H,12H)-dione C0123931
DISO_to_CHEMchemical_or_drug_has_physiologic_effectimg (4S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin- 9-yl (2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-1-benzopyran-6-yl Butanedioate C1883354
DISO_to_CHEMchemical_or_drug_has_physiologic_effectimg 1,2,4-Benzotriazin-3-amine, 1,4-dioxide C0208407
DISO_to_CHEMchemical_or_drug_has_physiologic_effectimg 1-(2-deoxy-beta-ribofuranosyl)-5-iodo-2-pyrimidinone C0088688
DISO_to_CHEMchemical_or_drug_has_physiologic_effectimg 2-((((2-chloroethyl)nitrosoamino)carbonyl)amino)propanamide C0045644
DISO_to_CHEMchemical_or_drug_has_physiologic_effectimg 4'-Deoxy-4'-Iododoxorubicin C0047758
DISO_to_CHEMchemical_or_drug_has_physiologic_effectimg 5 Bromo 2' deoxyuridine C0006233
DISO_to_CHEMchemical_or_drug_has_physiologic_effectimg 9-AC C0214192
DISO_to_CHEMchemical_or_drug_has_physiologic_effectimg AR-67 C0961890
DISO_to_CHEMchemical_or_drug_has_physiologic_effectimg CldC C1328172
DISO_to_CHEMchemical_or_drug_has_physiologic_effectimg EZN-2208 C2347621
DISO_to_CHEMchemical_or_drug_has_physiologic_effectimg Idoxuridine C0020811
DISO_to_CHEMchemical_or_drug_has_physiologic_effectimg Irinotecan hydrochloride C0594375
DISO_to_CHEMchemical_or_drug_has_physiologic_effectimg Pegylated Liposomal Irinotecan C1881411
DISO_to_CHEMchemical_or_drug_has_physiologic_effectimg Sodium phenylbutyrate C0718066
DISO_to_CHEMchemical_or_drug_has_physiologic_effectimg Topotecan Hydrochloride C0886549
DISO_to_CHEMchemical_or_drug_has_physiologic_effectimg becatecarin C0936065
DISO_to_CHEMchemical_or_drug_has_physiologic_effectimg irofulven C0532362
DISO_to_DISOisaimg Break, Double-Strand DNA C1511667
DISO_to_DISOisaimg Break, Single-Strand DNA C1511698
DISO_to_DISOused_forimg DNA Damage C0012860
DISO_to_PHYSbiological_process_results_from_biological_processimg DNA Damage Repair C0012899
Genes (6)

Species:
human : 6
SpeciesGeneGeneIdGene NameEvidence
HumanAPLF200558aprataxin and PNKP like factor
img GENERIF, Score=988, Pubmed Id: 17353262, UMLKSK CUI: C0872150
img GENERIF, Score=756, Pubmed Id: 17396150, UMLKSK CUI: C0872150
HumanNFKB14790nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
img GENERIF, Score=873, Pubmed Id: 17540609, UMLKSK CUI: C0872150
HumanGSTT12952glutathione S-transferase theta 1
img GENERIF, Score=988, Pubmed Id: 18325667, UMLKSK CUI: C0872150
HumanFANCD22177Fanconi anemia, complementation group D2
img GENERIF, Score=988, Pubmed Id: 18482162, UMLKSK CUI: C0872150
HumanCYP2E11571cytochrome P450, family 2, subfamily E, polypeptide 1
img GENERIF, Score=988, Pubmed Id: 17284772, UMLKSK CUI: C0872150
HumanPARP1142poly (ADP-ribose) polymerase 1
img GENERIF, Score=988, Pubmed Id: 18025084, UMLKSK CUI: C0872150
img GENERIF, Score=873, Pubmed Id: 18619636, UMLKSK CUI: C0872150
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0872150DNA Strand Break0self