Genes (25)
Species: human : 25 | |
Human | NPS | 594857 | neuropeptide S | NPS acts as a novel modulator of arousal and anxiety-related behaviours by promoting a unique pattern of effects: stimulation associated with anxiolysis | Human | ANKK1 | 255239 | ankyrin repeat and kinase domain containing 1 | for men, but not for women, we observed a strong and specific association between low neuroticism-anxiety and the A1+ allele of the DRD2 TaqI A polymorphism | Human | TPH2 | 121278 | tryptophan hydroxylase 2 | A significant association between harm avoidance (HA), a trait related to anxiety, and tryptophan hydroxylase 2 polymorphism | Human | DTNBP1 | 84062 | dystrobrevin binding protein 1 | DTNBP1 haplotypes, which have been found to be risk factors for schizophrenia, are unlikely to be risk factors for anxiety and depression | Human | GAL | 51083 | galanin/GMAP prepropeptide | The involvement of galanin is reviewed in the modulation of such functions as neurotransmitter release, memory, pain, depression, anxiety, obesity, gut motility, neuroendocrine regulation, development and neuroregeneration | Human | SGCE | 8910 | sarcoglycan, epsilon | Severe myoclonus-dystonia syndrome characterized by obsessive-compulsive disorder, depression, and anxiety was shown to be associated with a novel truncating mutation located within exon 4 of SGCE | Human | TPH1 | 7166 | tryptophan hydroxylase 1 | Title:Tryptophan hydroxylase gene 218A/C polymorphism is associated with somatic anxiety in major depressive disorder.|Association:Y|Conclusion:The polymorphism in serotonergic system related genes may be associated with depressive symptoms in major depressive disorder. The results suggest that analysis of clusters that narrow down the phenotype may be more suitable in genetic studies of major depressive illness. | Human | SNCA | 6622 | synuclein, alpha (non A4 component of amyloid precursor) | These results indicate a possible role for alpha-synuclein in anxiety-like behaviours | Human | SLC6A4 | 6532 | solute carrier family 6 (neurotransmitter transporter), member 4 | Click here to display 21 evidence detail records. | Human | SELP | 6403 | selectin P (granule membrane protein 140kDa, antigen CD62) | associations between negative affect (i.e., depressive and anxious symptoms) with increased norepinephrine and P-selectin responses to an acute psychological stress | Human | RGS2 | 5997 | regulator of G-protein signaling 2, 24kDa | variations of the Rgs2 gene play a role also for the development of anxiety in humans | Human | OXT | 5020 | oxytocin/neurophysin I prepropeptide | Depressed women had more variability in pulsatile oxytocin release during 2 test tasks, & higher oxytocin levels during the 1-hour affiliation-focused imagery session which were also associated with more depression, anxiety, & interpersonal dysfunction | Human | OPRM1 | 4988 | opioid receptor, mu 1 | Lack of association of a single-nucleotide polymorphism of the mu-opioid receptor gene with anxiety-related traits | Human | NPY | 4852 | neuropeptide Y | haplotype-driven NPY expression predicts brain responses to emotional and stress challenges and also inversely correlates with trait anxiety | Human | NGF | 4803 | nerve growth factor (beta polypeptide) | anxiety relates to a genetic variation of NGF and that genes modulate behaviour in a gender-dependent manner | Human | MAOA | 4128 | monoamine oxidase A | The monoamine oxidase-A gene may modify the association between the dopamine D2 receptor gene and alcohol dependence and anxiety, depression or both phenotype | Human | HTR3A | 3359 | 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic | HTR3A may have a role in the personality trait of anxiety, but may not play a major role in the etiology of panic disorder | Human | HTR1A | 3350 | 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled | multiple lines of evidence implicate the 5-HT1A receptor in the pathophysiology of anxiety and depression as well as in the mechanism of action of anxiolytics/antidepressants--REVIEW The observed reduction in hippocampal 5-HT1A receptor binding in male offspring after prenatal stress may have important consequences for adult anxiety- and depressive-like behavior Our findings further implicate relatively increased serotonin signaling, associated with a genetic variation that mediates increased 5-HT(1A) autoreceptors, in driving amygdala reactivity and trait anxiety The HTR1A gene may not play a major role in the genetic susceptibility underlying depressive and anxiety-related phenotypes | Human | FKBP5 | 2289 | FK506 binding protein 5 | In conclusion, there are differences of HADS anxiety score and FKBP5 mRNA expression in the leukocytes across the menstrual cycle but there is no correlation between anxiety scores and FKBP5 mRNA | Human | DRD2 | 1813 | dopamine receptor D2 | The associations of the dopamine receptor type 2 (DRD2) polymorphisms with the symptoms of anxiety were analyzed for men, but not for women, we observed a strong and specific association between low neuroticism-anxiety and the A1+ allele of the DRD2 TaqI A polymorphism Title:Comorbid migraine with aura anxiety and depression is associated with dopamine D2 receptor (DRD2) NcoI alleles.|Association:Y|Conclusion:These data indicate that MWA, anxiety disorders, and major depression can be components of a distinct clinical syndrome associated with allelic variations within the DRD2 gene. Clinical recognition of this genetically based syndrome has significant diagnostic and therapeutic implications. | Human | COMT | 1312 | catechol-O-methyltransferase | Two common functional polymorphisms in catechol-O-methyltransferase (COMT Val158Met) and brain-derived neurotrophic factor (BDNF Val66Met) genes have been implicated in the neurobiology of anxiety and depression Variations in the COMT gene contribute to genetic risk shared across a range of anxiety-related phenotypes The val158met polymorphism of COMT would be associated with both high neuroticism and low extraversion, making it a plausible candidate locus for anxiety susceptibility COMT gene contains a functional polymorphism, Va1158Met, which has been linked to anxiety and depression COMT (Val158Met) leads to neurobiology differences in executive cognitive function, stress/anxiety response, and opioid function that increase susceptibility to alcoholism There is an inherited difference in COMT polymorphism which is important in the pathogenesis of anxiety in women These data replicate previous findings suggesting association between the ValMet polymorphism and specific expressions of anxiety among females found no association between genetic variants and neuroticism, depression, anxiety, panic disorder and agarophobia, and obsessive compulsive disorder there was a double-recessive interaction effect in which the odds of reporting persisting generalized anxiety were more than twofold reduced among carriers homozygous for both the COMT Met(158) and the 5HTTLPR Short alleles | Human | CCK | 885 | cholecystokinin | This article reviews the corpus of work supporting the role of CCK in anxiety and suggests three research approaches which can further enhance our understanding of the CCK-2 system in panic disorder | Human | CAMK4 | 814 | calcium/calmodulin-dependent protein kinase IV | Transgenic CaMKIV plays a modulatory role in the nucleus accumbens in anxiety-like behavior of adult CaMKIV variant mice | Human | BDNF | 627 | brain-derived neurotrophic factor | BDNF variation and mood disorders: a novel functional promoter polymorphism and Val66Met are associated with anxiety The results of this study support the notion that allelic variation at the BDNF locus--in interaction with other gene variants--influences anxiety- and depression-related personality traits results do not support an association between BDNF Val66Met and anxiety, depression, or neuroticisim | Human | APOE | 348 | apolipoprotein E | This review discusses the differential effects of human apoE isoforms on anxiety in adult mice lacking apoE and in probable Alzheimer's disease patients |
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