Human | CCR2 | 729230 | chemokine (C-C motif) receptor 2 | the CCR2-64*I allele is more common in asthmatic patients, especially among atopic subjects |
Human | NPSR1 | 387129 | neuropeptide S receptor 1 | a common susceptibility factor for atopic manifestations in asthma is likely conferred by the locus containing the GPR154 gene |
Human | ORMDL3 | 94103 | ORM1-like 3 (S. cerevisiae) | a significant association between susceptibility to childhood atopic asthma and the polymorphism regulating ORMDL3 expression in a Japanese population |
Human | HRH4 | 59340 | histamine receptor H4 | STAT6 binding to STAT6 promotor gene was regulated by H4 receptor-induced signal transduction and/or cross talk particularly in atopic human lymphocytes ex vivo |
Human | FOXP3 | 50943 | forkhead box P3 | Increased IL-10 and Foxp3 induction in cord blood mononuclear cells of non-atopic compared to atopic mothers, may indicate an increased capacity to respond to microbial stimuli |
Human | CYSLTR1 | 10800 | cysteinyl leukotriene receptor 1 | discovered a CysLT1 G300S variant that is carried with a significantly higher frequency in atopics and asthmatics from the Tristan da Cunha population |
Human | VEGFA | 7422 | vascular endothelial growth factor A | Rhinovirus infection induces VEGF production in bronchial epithelial cells and airways, an effect enhanced in an atopic environment; Rhinovirus-associated, VEGF-mediated angiogenesis may contribute to airway remodeling in asthma |
Human | TLR4 | 7099 | toll-like receptor 4 | Polymorphisms in the TLR4 gene may be associated with milder forms of disease in atopic asthmatics in the Turkish children studied |
Human | TGFB2 | 7042 | transforming growth factor, beta 2 | TGF-beta(2) may therefore be involved in the development of childhood atopic asthma by means of functional genetic polymorphism |
Human | TBXA2R | 6915 | thromboxane A2 receptor | Title:Genetic variants of the receptors for thromboxane A2 and IL-4 in atopic dermatitis.|Association:Y|Conclusion:These results suggest TXA2 receptor polymorphism strongly interacts with IL-4Ralpha polymorphism as a major determinant of high serum immunoglobulin E levels in AD. |
Human | TAP2 | 6891 | transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) | Title:Distribution of TAP gene polymorphisms and extended MHC haplotypes in Mexican Mestizos and in Seri Indians from northwest Mexico.|Association:Not Found|Conclusion:These findings are the basis for further anthropological studies and to explore the contribution of TAP genes to disease expression in Mexicans. Title:Distribution of HLA-A, B alleles and polymorphisms of TAP and LMP genes in Korean patients with atopic dermatitis|Association:Y|Conclusion:This study demonstrates an association of atopic dermatitis with HLA-A24 and TAP2*C alleles in Korean patients. Discrepancy with the previous reports might be related to different patient characteristics and ethnic variations. |
Human | TAP1 | 6890 | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) | Title:Distribution of TAP gene polymorphisms and extended MHC haplotypes in Mexican Mestizos and in Seri Indians from northwest Mexico.|Association:Not Found|Conclusion:These findings are the basis for further anthropological studies and to explore the contribution of TAP genes to disease expression in Mexicans. |
Human | STAT6 | 6778 | signal transducer and activator of transcription 6, interleukin-4 induced | STAT6 binding to STAT6 promotor gene was regulated by H4 receptor-induced signal transduction and/or cross talk particularly in atopic human lymphocytes ex vivo |
Human | STAT1 | 6772 | signal transducer and activator of transcription 1, 91kDa | The polymorphism C39134A, located in a potentially cis acting regulatory element in STAT1 intron 24, was inversely related to total IgE levels and atopic sensitization in German children |
Human | CCL24 | 6369 | chemokine (C-C motif) ligand 24 | Intradermal injection of CCL24 induces recruitment of eosinophils, basophils, neutrophils, and macrophages as well as features of early- and late-phase allergic reactions in atopic and nonatopic volunteers |
Human | CCL18 | 6362 | chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) | Regulation of CCL18 by allergen exposure and microbial products suggests its important role in the initiation and amplification of atopic skin inflammation |
Human | CCL11 | 6356 | chemokine (C-C motif) ligand 11 | Title:Eotaxin gene single nucleotide polymorphisms in the promoter and exon regions are not associated with susceptibility to atopic dermatitis, but two of them in the promoter region are associated with serum IgE levels in patients with atopic dermatitis.|Association:Y|Conclusion:Eotaxin gene SNPs in the promoter and exon regions are not associated with susceptibility to AD, but two of them in the promoter region are associated with phenotype of AD. Intradermal injection of CCL11 induces recruitment of eosinophils, basophils, neutrophils, and macrophages as well as features of early- and late-phase allergic reactions in atopic and nonatopic volunteers |
Human | CCL3 | 6348 | chemokine (C-C motif) ligand 3 | CCL2 and CCL3 induce both immediate and delayed skin reactions in atopics and nonatopics, and evoke a similar profile of local T cell/macrophage and granulocyte recruitment |
Human | CCL2 | 6347 | chemokine (C-C motif) ligand 2 | CCL2 and CCL3 induce both immediate and delayed skin reactions in atopics and nonatopics, and evoke a similar profile of local T cell/macrophage and granulocyte recruitment |
Human | CCL1 | 6346 | chemokine (C-C motif) ligand 1 | the axis CCL1-CCR8 links adaptive and innate immune functions that play a role in the initiation and amplification of atopic skin inflammation |
Human | RNASE2 | 6036 | ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) | Data show that uEPX/c levels did not correlate with established markers of asthma severity and eosinophilic airway inflammation in atopic asthmatic children |
Human | PSMB8 | 5696 | proteasome (prosome, macropain) subunit, beta type, 8 | Title:Distribution of HLA-A, B alleles and polymorphisms of TAP and LMP genes in Korean patients with atopic dermatitis|Association:Not Found|Conclusion:This study demonstrates an association of atopic dermatitis with HLA-A24 and TAP2*C alleles in Korean patients. Discrepancy with the previous reports might be related to different patient characteristics and ethnic variations. |
Human | PPIA | 5478 | peptidylprolyl isomerase A (cyclophilin A) | cyclophilin A gene was identified as the most suitable normaliser in gene expression studies involving human airway epithelial cells derived from normal, atopic and asthmatic children |
Human | PAFAH1B1 | 5048 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | Val279Phe polymorphism is activity-deficient and is associated with increased risk of childhood atopic asthma |
Human | MMP9 | 4318 | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | 17 polymorphisms associated with the risk of childhood atopic asthma were identified in MMP-9 |