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Genes (29)
Species: human : 29 | |
Human | P2RY12 | 64805 | purinergic receptor P2Y, G-protein coupled, 12 | The P2Y(13) Met-158-Thr polymorphism is in tight linkage disequilibrium with the P2Y(12) locus but is not associated with acute myocardial infaction or classical cardiovascular risk factors | Human | TRIB3 | 57761 | tribbles homolog 3 (Drosophila) | The prevalent TRB3 missense Q84R polymorphism is significantly associated with several insulin resistance-related abnormalities and with the presence of a cluster of cardiovascular risk factors | Human | RETN | 56729 | resistin | Genetic variants at the RETN locus are associated with the plasma RETN concentration and cardiovascular risk factors | Human | ADIPOQ | 9370 | adiponectin, C1Q and collagen domain containing | increase of adiponectin concentrations or the maintenance of higher concentration may be negatively associated with cardiovascular risk factors in nondiabetic coronary artery disease male patients polymorphisms of the adiponectin gene independently contribute to insulin resistance and other cardiovascular disease risk factors Hypoadiponectinemia is a novel putative cardiovascular risk factor in patients with mild and moderate renal failure low levels of adiponectin are associated with adverse changes in morphology and function of central arteries over time independently of other cardiovascular risk factors in postmenopausal non-diabetic women | Human | PLA2G7 | 7941 | phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) | Lipoprotein-associated phospholipase A(2) (Lp-PLA(2))is strongly correlated with several cardiovascular risk factors Lp-PLA(2) was associated with incident ischemic stroke independently of C-reactive protein and traditional cardiovascular risk factors among nonusers of hormone therapy with highest risk in those who had both high C-reactive protein and high Lp-PLA(2) | Human | USF1 | 7391 | upstream transcription factor 1 | significant associations between relatively common USF1 genetic variants and Cardiovascular risk factors were observed in French Canadians USF1 variants associate with the metabolic syndrome at population level and influence cardiovascular risk factors throughout adulthood in a consistent, longitudinal manner | Human | ABCC8 | 6833 | ATP-binding cassette, sub-family C (CFTR/MRP), member 8 | SUR1 exon 16-3 cytosine/thymine polymorphism is a partial determinant of acute hyperglycaemia-cardiovascular risk factor in type 2 diabetes | Human | PTPN1 | 5770 | protein tyrosine phosphatase, non-receptor type 1 | Our results from a sample of Iranian type 2 diabetes cases and controls provide evidence that the 1484insG genotype of the PTPN1 gene may be associated with insulin resistance and other cardiovascular risk factors in non-diabetic male subjects | Human | PPARG | 5468 | peroxisome proliferator-activated receptor gamma | Title:A Pro12Ala polymorphism in the human peroxisome proliferator-activated receptor-gamma 2 is associated with combined hyperlipidaemia in obesity.|Association:Y|Conclusion:Obese carriers of the Pro12Ala polymorphism have a greater risk of developing combined hyperlipidaemia, possibly due to impaired activation of PPAR gamma target genes. The Pro12Ala polymorphism is not directly associated with obesity, hypertension or diabetes in this population. | Human | NOS3 | 4846 | nitric oxide synthase 3 (endothelial cell) | The present study demonstrates that polymorphisms of the eNOS -786T>C and 4a4b are associated with coronary artery disease with adjustments for cardiovascular risk factors in the Koreans | Human | MTHFR | 4524 | methylenetetrahydrofolate reductase (NAD(P)H) | Title:|Association:Not Found|Conclusion:Not Found Risk of migraineurs with aura is associated with MTHFR C674T homozygosity, independent of other cardiovascular risk factors | Human | MBL2 | 4153 | mannose-binding lectin (protein C) 2, soluble | MBL genotype modulates arterial stiffness, an important cardiovascular risk factor, in children after Kawasaki disease | Human | LRP6 | 4040 | low density lipoprotein receptor-related protein 6 | results link a mutation in LRP6 which encodes a co-receptor in the Wnt signaling pathway to coronary artery disease and multiple cardiovascular risk factors | Human | ITGA2 | 3673 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | Our findings support the view that C807T polymorphism of the GPla gene is not a significant risk factor for CAD, either alone or in combination with other major cardiovascular risk factors | Human | IL6 | 3569 | interleukin 6 (interferon, beta 2) | IL-6 may have a potential role as a mediator between cardiovascular risk factors and several biological mechanisms for cardiovascular disease | Human | IGF1 | 3479 | insulin-like growth factor 1 (somatomedin C) | These data point to an interesting relationship between low IGF-1 levels and increased cardiovascular risk factors among chronic kidney disease patients as compared to age-matched healthy control subjects | Human | HSD11B1 | 3290 | hydroxysteroid (11-beta) dehydrogenase 1 | relationship between circulating 11beta-HSD1 mRNA levels & cardiovascular risk factors; results suggest decreased expression of 11beta-HSD1 with increased smoking, BMI & length of menopause; increased expression seen with increasing age & alcohol intake | Human | NR3C1 | 2908 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | We did not find differences in cardiovascular risk factors between GR haplotypes | Human | FCGR2A | 2212 | Fc fragment of IgG, low affinity IIa, receptor (CD32) | conclude that the G507A polymorphism does not contribute to risk of myocardial infarction, either alone of in combination with established cardiovascular risk factors | Human | ESR1 | 2099 | estrogen receptor 1 | Postmenopausal women who carry ESR1 haplotype 1 (c.454-397 T allele and c.454-351 A allele) have an increased risk of myocardial infarction and ischemic heart disease, independent of known cardiovascular risk factors | Human | ACE | 1636 | angiotensin I converting enzyme | The angiotensin-converting enzyme (ACE) I/D and the alpha-adducin (ADD1) Gly460Trp polymorphisms are associated with cardiovascular risk factors Title:Association of ACE I/D polymorphism with cardiovascular risk factors.|Association:Y|Conclusion:Not Found ACE I/D polymorphism might play a role in the development of obesity and hypertension, which are closely linked cardiovascular risk factors | Human | CST3 | 1471 | cystatin C | Increased CST3 is associated with an enhanced cardiovascular risk factor profile in Aboriginal youth | Human | CRP | 1401 | C-reactive protein, pentraxin-related | The pleiotropic association between CRP and obesity, adipokines and cardiovascular risk factors might prove it to be an important link between inflammatory reaction and atherogenesis in which adipose tissue hormones are involved In a population-based cohort of African Americans, circulating CRP concentration was heritable and associated with several traditional cardiovascular risk factors, particularly body mass index Study suggests that in essential hypertension there is an association between protein-bound sialic acid and C-reactive protein, which reflects the clustering of cardiovascular risk factors in these patients | Human | CNR2 | 1269 | cannabinoid receptor 2 (macrophage) | Data suggest that common polymorphisms within the cannabinoid receptor 2 gene confer no susceptibility to myocardial infarction or to cardiovascular risk factors | Human | APOE | 348 | apolipoprotein E | in old age, except for epsilon2-allele carriers, high plasma apoE levels are associated with a higher risk of stroke, independent of APOE genotype, plasma levels of lipids, and other cardiovascular risk factors in old age, in non-epsilon2-allele carriers, high plasma apoE levels are associated with cognitive impairments, independent of genotype, cardiovascular risk factors, and stroke |
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