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Genes (30)
Species: human : 30 | |
Human | MYO18B | 84700 | myosin XVIIIB | The restored expression of MYO18B may be a useful therapeutic strategy for the treatment of locally advanced Malignant pleural mesothelioma(MPM)in humans | Human | AVEN | 57099 | apoptosis, caspase activation inhibitor | point mutation observed by transcriptome sequencing of malignant pleural mesothelioma tumors | Human | ITLN1 | 55600 | intelectin 1 (galactofuranose binding) | Identification of intelectin overexpression in malignant pleural mesothelioma by serial analysis of gene expression (SAGE). | Human | CADM1 | 23705 | cell adhesion molecule 1 | Appears to mediate efficient adhesion and growth of malignant pleural mesothelioma cells specifically on mesothelial cells, probably via trans-heterophilic binding | Human | YAP1 | 10413 | Yes-associated protein 1 | this is the first report of negative regulatory signaling from Merlin to YAP1 in mammalian cells and may shed light on mechanisms of malignant pleural mesothelioma development | Human | MSLN | 10232 | mesothelin | data support soluble mesothelin-related peptide as a promising marker for malignant pleural mesothelioma in both serum and pleural effusion fluid in asbestos-exposed cohorts Significantly higher soluble mesothelin-related protein is associated with malignant pleural mesothelioma diagnostic value of Megakaryocyte potentiating factor for malignant pleural mesothelioma was better than that of mesothelin although both markers showed almost equal specificity for MPM | Human | PDZK1IP1 | 10158 | PDZK1 interacting protein 1 | point mutation observed by transcriptome sequencing of malignant pleural mesothelioma tumors | Human | ACTR1A | 10121 | ARP1 actin-related protein 1 homolog A, centractin alpha (yeast) | point mutation observed by transcriptome sequencing of malignant pleural mesothelioma tumors | Human | UPK3A | 7380 | uroplakin 3A | Not a useful immunohistochemical marker for detection of pleural malignant mesothelioma | Human | TXN | 7295 | thioredoxin | Up-regulation of thioredoxin and thioredoxin reductase in human malignant pleural mesothelioma. Six cases of nonmalignant, histologically healthy pleural mesothelium showed no Trx or TrxR immunoreactivity, whereas immunohistochemistry on 26 biopsies of human malignant pleural mesothelioma showed positive Trx in all cases and positive TrxR in 23 (88%) of the cases. We assessed the Trx system in malignant pleural mesothelioma cell lines, in nonmalignant pleural mesothelium and in biopsies of malignant pleural mesothelioma. | Human | TP53 | 7157 | tumor protein p53 | p53 is functional in the absence of p14(ARF) in malignant pleural mesothelioma | Human | TNNI3 | 7137 | troponin I type 3 (cardiac) | In five patients who were treated for malignant pleural mesothelioma (MPM) with pleuropneumonectomy and intraoperative photodynamic therapy (IPDT), impending myocardial damage was monitored using ECG, the classical biochemical markers (creatine kinase [CK], total activity; CKMB, mass; and myoglobin), and the new cardiac markers troponin I (cTnI) and troponin T (cTnT). | Human | TIMP1 | 7076 | TIMP metallopeptidase inhibitor 1 | We examined immunohistochemically the expression of MMPs (MMP-1, -2, -3, -7, and -9), TIMPs (TIMP-1 and -2), and collagens (types I, III, and IV) in 16 patients with pleural malignant mesothelioma (PMM; 8 with the epithelial, 4 with the sarcomatous, and 4 with the biphasic type). | Human | SRC | 6714 | v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog | Activated c-Src may play a role in survival, metastasis, and invasion of malignant pleural mesothelioma | Human | SPP1 | 6696 | secreted phosphoprotein 1 | Osteopontin expression was significantly lower in long-term compared with short-term survivors of malignant pleural mesothelioma (P< .0001), and overall survival analysis showed that low osteopontin expression was associated with longer survival Frequent osteopontin expression is typical of, but not specific for malignant pleural mesothelioma, whereas it appears to select pulmonary adenocarcinoma cases with p65 and MMP-9 expression, suggesting a link with EGFR signalling pathways | Human | REN | 5972 | renin | METHODS: Malignant pleural mesothelioma lines REN (epithelial) and I-45 (sarcomatous) were exposed to modified bcl-xl antissense oligonecleotides directed near the messenger RNA initiation sequence with and without a liposomal delivery system. | Human | NF2 | 4771 | neurofibromin 2 (merlin) | this is the first report of negative regulatory signaling from Merlin to YAP1 in mammalian cells and may shed light on mechanisms of malignant pleural mesothelioma development | Human | MKI67 | 4288 | antigen identified by monoclonal antibody Ki-67 | No significant association was observed between FHIT and Ki-67 expression in malignant pleural mesothelioma | Human | LGALS3BP | 3959 | lectin, galactoside-binding, soluble, 3 binding protein | The expression of the tumour-associated glycoprotein 90K in patients with malignant pleural mesothelioma (MM) has not been described. Expression of glycoprotein 90K in human malignant pleural mesothelioma: correlation with patient survival. | Human | L1CAM | 3897 | L1 cell adhesion molecule | L1CAM, INP10, P-cadherin, tPA and ITGB4 over-expression in malignant pleural mesotheliomas revealed by combined use of cDNA and tissue microarray. | Human | ITGB4 | 3691 | integrin, beta 4 | L1CAM, INP10, P-cadherin, tPA and ITGB4 over-expression in malignant pleural mesotheliomas revealed by combined use of cDNA and tissue microarray. | Human | GDF10 | 2662 | growth differentiation factor 10 | BMP3b and BMP6 genes were suppressed by DNA methylation and methylation of BMP3b is significantly frequent in Japanese malignant pleural mesotheliomas (MPMs), suggesting its pathogenic role and the ethnic difference in MPMs | Human | XRCC6 | 2547 | X-ray repair complementing defective repair in Chinese hamster cells 6 | point mutation observed by transcriptome sequencing of malignant pleural mesothelioma tumors | Human | FLT1 | 2321 | fms-related tyrosine kinase 1 | The observed coexpression of VEGF and flt-1 possibly suggests a potential autocrine loop for malignant pleural mesothelioma cells. Co-expression of vascular endothelial growth factor and its receptor flt-1 in malignant pleural mesothelioma. | Human | EGFR | 1956 | epidermal growth factor receptor | In malignant pleural mesothelioma, epidermal growth factor receptor to play a role in a limited subset of patients |
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