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Details
Link-It Detail - Disease - Lewy Body Disease
Debug Stats
  • ### Total Build Time: 193 ms 45.074 KB
  • CONCEPT_NAME gt=14 ms Completed: 14 ms rowSize= 332 bytes
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  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Lewy Body Disease C0752347
Definition (1)

Lewy body disease is one of the most common causes of dementia in the elderly. Dementia is the loss of mental functions severe enough to affect normal activities and relationships. Lewy body disease happens when abnormal structures, called Lewy bodies, build up in areas of the brain. The disease may cause a wide range of symptoms, including

  • Changes in alertness and attention
  • Hallucinations
  • Problems with movement and posture
  • Muscle stiffness
  • Confusion
  • Loss of memory

Lewy body disease can be hard to diagnose, because Parkinson's disease and Alzheimer's disease cause similar symptoms. Scientists think that Lewy body disease might be related to these diseases, or that they sometimes happen together.

Lewy body disease usually begins between the ages of 50 and 85. The disease gets worse over time. There is no cure. Treatment focuses on drugs to help symptoms.

NIH: National Institute of Neurological Disorders and Stroke

Semantic Types (1)
Disease or Syndrome (T047)
Parents (3)
img Parkinsonian Disorders C0242422
img Neurodegenerative Diseases C0524851
img Dementia C0497327
Ancestral Roots
RootRoot Plus OneDepthParent
img Nervous System Diseases C0027765img Central Nervous System Diseases C00076825img Parkinsonian Disorders C0242422
img Nervous System Diseases C0027765img Central Nervous System Diseases C00076826img Parkinsonian Disorders C0242422
img Nervous System Diseases C0027765img Neurodegenerative Diseases C05248513img Neurodegenerative Diseases C0524851
img Nervous System Diseases C0027765img Central Nervous System Diseases C00076825img Dementia C0497327
img Mental Disorders C0004936img Delirium, Dementia, Amnestic, Cognitive Disorders C00292274img Dementia C0497327
Relationships (67)

Relation Types:
diso_​to_​anat : 12
diso_​to_​chem : 15
diso_​to_​diso : 36
diso_​to_​gene : 2
diso_​to_​phen : 2


Relationships:
none : 38
associated_​with : 1
classifies : 2
gene_​associated_​with_​disease : 2
gene_​product_​malfunction_​associated_​with_​disease : 1
is_​associated_​anatomic_​site_​of : 2
isa : 1
manifestation_​of : 12
mapped_​to : 3
related_​to : 5
Page Size
Current 25
  Page 1 of 3
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_DISO168img Parkinson Disease C0030567
DISO_to_DISO147img Alzheimer Disease C0002395
DISO_to_DISO146img Alzheimer Disease C0002395
DISO_to_DISO120img Complication Aspects C1171258
DISO_to_DISO110img Parkinson Disease C0030567
DISO_to_ANAT106img Brain C0006104
DISO_to_ANAT76img Brain C0006104
DISO_to_CHEM76img alpha-Synuclein C0285890
DISO_to_DISO76img Complication Aspects C1171258
DISO_to_PHEN72img genetic aspects C0017399
DISO_to_DISO66img Dementia C0497327
DISO_to_PHEN62img genetic aspects C0017399
DISO_to_DISO43img Cognition Disorders C0009241
DISO_to_ANAT39img Bodies, Lewy C0085200
DISO_to_ANAT37img Bodies, Lewy C0085200
DISO_to_CHEM36img Nerve Tissue Proteins C0027759
DISO_to_DISO32img Dementia C0497327
DISO_to_CHEM28img Cholinesterase Inhibitors C0008425
DISO_to_CHEM24img Amyloid beta-Peptides C0078939
DISO_to_ANAT23img Neurons C0027882
DISO_to_DISO23img Cognition Disorders C0009241
DISO_to_CHEM22img Cholinesterase Inhibitors C0008425
DISO_to_DISO22img Hallucinations C0018524
DISO_to_ANAT19img Cerebral Cortex C0007776
DISO_to_ANAT18img Neurons C0027882
Genes (13)

Species:
human : 13
SpeciesGeneGeneIdGene NameEvidence
HumanLRRK2120892leucine-rich repeat kinase 2
img GENERIF, Score=756, Pubmed Id: 16437559, UMLKSK CUI: C0752347
HumanRPH3A22895rabphilin 3A homolog (mouse)
img GENERIF, Score=1000, Pubmed Id: 15207266, UMLKSK CUI: C0752347
HumanTUBA1B10376tubulin, alpha 1b
img GENERIF, Score=906, Pubmed Id: 18195004, UMLKSK CUI: C0752347
HumanTH7054tyrosine hydroxylase
img GENERIF, Score=923, Pubmed Id: 17985144, UMLKSK CUI: C0752347
HumanSNCA6622synuclein, alpha (non A4 component of amyloid precursor)
img GENERIF, Score=906, Pubmed Id: 18195004, UMLKSK CUI: C0752347
img GENERIF, Score=884, Pubmed Id: 15304594, UMLKSK CUI: C0752347
img GENERIF, Score=906, Pubmed Id: 16847063, UMLKSK CUI: C0752347
img GENERIF, Score=1000, Pubmed Id: 15207266, UMLKSK CUI: C0752347
img GENERIF, Score=861, Pubmed Id: 18413475, UMLKSK CUI: C0752347
img GENERIF, Score=1000, Pubmed Id: 16947080, UMLKSK CUI: C0752347
img GENERIF, Score=923, Pubmed Id: 15622440, UMLKSK CUI: C0752347
HumanSLC6A36531solute carrier family 6 (neurotransmitter transporter), member 3
img GENERIF, Score=1000, Pubmed Id: 15210531, UMLKSK CUI: C0752347
HumanPARK25071parkinson protein 2, E3 ubiquitin protein ligase (parkin)
img GENERIF, Score=906, Pubmed Id: 18195004, UMLKSK CUI: C0752347
img GENERIF, Score=1000, Pubmed Id: 15105460, UMLKSK CUI: C0752347
HumanNR4A24929nuclear receptor subfamily 4, group A, member 2
img GENERIF, Score=1000, Pubmed Id: 12756136, UMLKSK CUI: C0752347
HumanNOS34846nitric oxide synthase 3 (endothelial cell)
img GENERIF, Score=1000, Pubmed Id: 14639046, UMLKSK CUI: C0752347
HumanGBA2629glucosidase, beta, acid
img GENERIF, Score=1000, Pubmed Id: 18852351, UMLKSK CUI: C0752347
HumanAQP4361aquaporin 4
img GENERIF, Score=1000, Pubmed Id: 16871401, UMLKSK CUI: C0752347
HumanAPP351amyloid beta (A4) precursor protein
img GENERIF, Score=1000, Pubmed Id: 18794492, UMLKSK CUI: C0752347
HumanAPOE348apolipoprotein E
img GENERIF, Score=1000, Pubmed Id: 16956959, UMLKSK CUI: C0752347
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0752347Lewy Body Disease0self