Human | IKZF3 | 22806 | IKAROS family zinc finger 3 (Aiolos) | We did not detect any overexpression of dominant negative isoforms of Aiolos in adult ALL patients. We analyzed the expression levels of the Ikaros gene family, Ikaros and Aiolos, in human bone marrow samples from patients with adult acute lymphoblastic leukemia [ALL (n = 46; B-cell ALL = 41; T-cell ALL = 5)]. |
Human | MVP | 9961 | major vault protein | P-glycoprotein (P-gp), lung resistance-related protein (LRP) and multidrug resistance-associated protein (MRP) expression, and blast cell intracellular daunorubicin accumulation (IDA) were evaluated in 95 previously untreated cases of adult acute lymphoblastic leukaemia (ALL) using flow cytometry. |
Human | XRCC5 | 7520 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | Conclusions: Our study suggests that Ku80 might contribute to generally poor prognoses in adult ALL. The Ku80 was significantly higher in adult than in pediatric ALL (P = 0.02). |
Human | TRB@ | 6957 | | TCRB gene rearrangements in childhood and adult precursor-B-ALL: frequency, applicability as MRD-PCR target, and stability between diagnosis and relapse. |
Human | SHMT1 | 6470 | serine hydroxymethyltransferase 1 (soluble) | BACKGROUND AND OBJECTIVES: Polymorphisms in thymidylate synthase (TS) 28-bp tandem repeats in the promoter region and in cytosolic serine hydroxymethyltransferase (SHMT1 C1420T) have been reported to modulate the risk of adult acute lymphocytic leukemia (ALL). |
Human | RGS2 | 5997 | regulator of G-protein signaling 2, 24kDa | G0S8 expression was observed in most fresh samples of acute myelogenous leukemia (AML) (28/30) and most cases of adult acute lymphoblastic leukemia (ALL) (9/11) regardless of clinical classification. |
Human | MAPK1 | 5594 | mitogen-activated protein kinase 1 | phosphorylated-ERK1/2 expression was an independent predictor of complete remission achievement in adult acute lymphoblastic leukemia |
Human | ABCB1 | 5243 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 | MDR1 protein expression is an independent predictor of complete remission in newly diagnosed adult acute lymphoblastic leukemia |
Human | MTRR | 4552 | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase | In a case-control study, we evaluated whether four common polymorphisms in methylenetetrahydrofolate reductase (MTHFR C677T and A1298C), methionine synthase (MS A2756G), and methionine synthase reductase (MTRR A66G) genes may have a role in altering susceptibility to adult acute lymphoblastic leukemia (ALL) and non-Hodgkin;s lymphoma (NHL). |
Human | MTHFR | 4524 | methylenetetrahydrofolate reductase (NAD(P)H) | Based on a meta-analysis, the common genetic C677T polymorphism in the MTHFR contributes to the risk of adult ALL, but not to the childhood ALL susceptibility |
Human | MME | 4311 | membrane metallo-endopeptidase | data identify CD10- cytoplasmic immunoglobulin-positive pre-B ALL as a rare (2.2%) but distinct immuno-subtype of adult ALL that is characterized by a high MLL rearrangement rate and a worse outcome |
Human | FLT3 | 2322 | fms-related tyrosine kinase 3 | Activating mutations in the FLT3 RTK gene were found in each of 3 CD117/KIT(+) cases that were analyzed, but not in 52 other adult T-acute lymphoblastic leukemia |
Human | ERG | 2078 | v-ets avian erythroblastosis virus E26 oncogene homolog | High expression of ERG is an adverse risk factor in adult T-ALL |
Human | DLX4 | 1748 | distal-less homeobox 4 | BP1 gene could not be detected in adult acute lymphoid leukemia. BP1 gene could not be detected in adult acute lymphoid leukemia. |
Human | CYP1A1 | 1543 | cytochrome P450, family 1, subfamily A, polypeptide 1 | data indicate that the CYP1A1*2A genotype contributes significantly to susceptibility to adult acute lymphoblastic leukemia in a sample of the Mexican population |
Human | CD33 | 945 | CD33 molecule | RESULTS: The incidence of myeloid antigen expression in adult ALL was 21.6% and the commonest one was CD33 (15.7%). |
Human | RUNX1 | 861 | runt-related transcription factor 1 | TEL/AML1 rearrangement is not unique in childhood ALL, and cryptic TEL deletion without TEL/AML1 rearrangement was more frequent than the TEL/AML1 rearrangement in adult ALL |
Human | CEACAM1 | 634 | carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) | The association between CD66 reactivity and bcr-abl in adult ALL remains to be investigated. |
Human | ATM | 472 | ataxia telangiectasia mutated | These observations indicate that as in adult ALL, complete ATM submicroscopic deletion is frequent in childhood B-precursor ALL Considering the aberrations in the ATM gene in CLL and the high rate of incidence of lymphoid neoplasias in AT patients, the authors investigated its incidence rate and significance in patients with adult acute lymphoblastic leukemia (ALL). |