Human | LRRC4 | 64101 | leucine rich repeat containing 4 | LRRC4 is a novel relatively specific gene, which displays significant down-regulation in primary brain tumor biopsies and has the potential to suppress brain tumor growth. BACKGROUND : LRRC4 is a novel gene that the author has identified recently, which displayed significant downregulation in primary brain tumor biopsies. |
Human | BCAN | 63827 | brevican | Further understanding of BEHAB/brevican isoforms will advance our knowledge of the function of this ECM component and may help identify new potential therapeutic targets for primary brain tumors. |
Human | DEC1 | 50514 | deleted in esophageal cancer 1 | DEC1 expression is found in the majority of 1p-aberrant oligodendroglial neoplasms; its immunohistochemical detection does not correlate with tisue hypoxia in this type of primary brain tumor |
Human | NUPR1 | 26471 | nuclear protein, transcriptional regulator, 1 | In the present study distinct com1 mRNA expression was detected in cerebral metastases from patients with lung carcinomas, whereas the expression level was generally much lower in glioblastomas (primary brain tumors). |
Human | ADAM28 | 10863 | ADAM metallopeptidase domain 28 | In this work, we have examined the expression level and the methylation status of the 5; upstream region of the adhesion molecule ADAM23 in two brain tumor cell lines (A172 and T98G) as well as in three primary brain tumors (one grade II astrocytoma and two meningiomas) and 15 glioblastoma xenografts. |
Human | TUBB3 | 10381 | tubulin, beta 3 class III | study concludes that class III beta-tubulin is expressed in some cases of major primary brain tumour types except pilocytic astrocytoma; extent of class III beta-tubulin expression is variable |
Human | OLIG2 | 10215 | oligodendrocyte lineage transcription factor 2 | CONCLUSIONS: Widespread OLIG2 expression discriminates oligodendroglial neoplasms or DNTs from other clear cell primary brain tumour types. In clear cell primary brain tumours lacking OLIG2 expression, differential diagnosis may require additional immunohistochemical markers. |
Human | HYAL2 | 8692 | hyaluronoglucosaminidase 2 | more elevated in human brain metastases than in primary brain tumours |
Human | BHLHE40 | 8553 | basic helix-loop-helix family, member e40 | Thus, immunohistochemical analysis of DEC1 expression is in our hands not suitable for detection of tissue hypoxia in this type of primary brain tumor. |
Human | ENC1 | 8507 | ectodermal-neural cortex 1 (with BTB domain) | NRP/B mutations impair Nrf2-dependent NQO1 induction in primary brain tumors |
Human | CXCR4 | 7852 | chemokine (C-X-C motif) receptor 4 | A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors. |
Human | TIMP1 | 7076 | TIMP metallopeptidase inhibitor 1 | Together these data demonstrate that the different primary brain tumors show distinct regulation of MMP and TIMP genes. |
Human | SULT1A1 | 6817 | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 | SULT1A1 polymorphism is associated with primary brain tumors |
Human | PROS1 | 5627 | protein S (alpha) | Ten primary brain tumor tissues also expressed protein S antigen, as shown by western blot analysis. |
Human | PMS2 | 5395 | PMS2 postmeiotic segregation increased 2 (S. cerevisiae) | Turcot syndrome is clinically characterized by the occurrence of primary brain tumor and colorectal tumor and has, in previous reports, been shown associated with germline mutations in the genes APC, MLH1, MHS6, and PMS2. |
Human | MTHFR | 4524 | methylenetetrahydrofolate reductase (NAD(P)H) | The MTHFR A1298C and C677T genotypes significantly influenced the risk of primary brain tumor |
Human | MHS6 | 4266 | malignant hyperthermia susceptibility 6 | Turcot syndrome is clinically characterized by the occurrence of primary brain tumor and colorectal tumor and has, in previous reports, been shown associated with germline mutations in the genes APC, MLH1, MHS6, and PMS2. |
Human | GRN | 2896 | granulin | The differential expression pattern, tissue distribution, and implication of this glioma-associated molecule in growth regulation suggest a potentially important role for granulin in the pathogenesis and/or malignant progression of primary brain neoplasms. |
Human | GHRH | 2691 | growth hormone releasing hormone | The GH-releasing effect of GHRH plus GH secretagogue [GH-releasing peptide (GHRP)-6] (GHRH+GHRP-6) was studied in 22 adult patients (age, 23.2 +/- 1.4 yr; 8 female and 14 male; mean body mass index, 22.6 +/- 0.7 kg/m(2)) who received cranial radiation for primary brain tumor distant from hypothalamic-pituitary region 7.6 +/- 0.7 yr before GH testing. |
Human | DMBT1 | 1755 | deleted in malignant brain tumors 1 | A total of 102 primary brain tumors, consisting of 25 glioblastoma multiforme, 24 medulloblastoma and 53 oligodendroglial tumors, were analyzed by conformation-sensitive gel electrophoresis in all 54 coding exons of DMBT1. |
Human | DFFA | 1676 | DNA fragmentation factor, 45kDa, alpha polypeptide | The present findings suggest that primary brain tumors and normal brain constitutively express ICAD / DFF, and that there is a difference between the expression levels of ICAD-L and ICAD-S. |
Human | DAG1 | 1605 | dystroglycan 1 (dystrophin-associated glycoprotein 1) | DG may be involved in the progression of primary brain tumors |
Human | CSTA | 1475 | cystatin A (stefin A) | Histological sections of 100 primary brain tumors, 27 benign and 73 malignant, were stained immunohistochemically for Cat B and stefin A. |
Human | CD68 | 968 | CD68 molecule | While using the MAB CD 68 applied to paraffin embedded tissue specimen, macrophages could be marked in 31 primary brain tumors of glial origin and in 17 metastatic tumors from which 7 were carcinomas of the lung, 5 carcinomas of the breast, 2 from the digestive tract and 3 were clear cell carcinomas of the kidney. |
Human | CALD1 | 800 | caldesmon 1 | In the present study, we identified 2 candidate tumor-related proteins, N-myc oncoprotein and low-molecular weight caldesmon (l-CaD), in CSF samples of patients with primary brain tumors by using 2-dimensional polyacrylamide gel electrophoresis (2D PAGE), followed by matrix-assisted laser desorption/ionization-time of flight-mass spectrometry (MALDI-TOF-MS) analysis. |