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Genes (43)
Species: human : 43 | |
Human | FLCN | 201163 | folliculin | BHD is involved in the entire spectrum of histological types of renal tumors, suggesting its major role in kidney cancer tumorigenesis | Human | PHF17 | 79960 | PHD finger protein 17 | Jade-1 is a novel candidate transcriptional co-activator associated with HAT activity and may play a key role in the pathogenesis of renal cancer and von Hippel-Lindau disease | Human | CDC73 | 79577 | cell division cycle 73 | renal cancer-associated mutations in parafibromin occur in the absence of von Hippel-Lindau mutation | Human | PBRM1 | 55193 | polybromo 1 | cDNA cloning; the hPB1 gene is located on chromosome 3p21, where the tumor suppressor genes for breast, lung and kidney cancers have been mapped | Human | ANGPTL4 | 51129 | angiopoietin-like 4 | Other benign and malignant renal tumor cells do not produce ANGPTL4 mRNA. | Human | CACYBP | 27101 | calcyclin binding protein | Taken together, our work showed that CacyBP/SIP, as a novel down-regulated gene in renal cell carcinoma, suppressed proliferation and tumorigenesis of renal cancer cells | Human | NDRG1 | 10397 | N-myc downstream regulated 1 | Downregulation of Cap43 gene by von Hippel-Lindau tumor suppressor protein in renal cancer cells | Human | ABCG2 | 9429 | ATP-binding cassette, sub-family G (WHITE), member 2 | Title:Detection of single nucleotide polymorphisms in the ABCG2 gene in a Dutch population.|Association:Not Found|Conclusion:The results will be used in future studies to explore the influence of the different SNPs on ABCG2 protein expression, activity, and substrate specificity. In addition, the results can be used to study the effects of genetic polymorphisms in the ABCG2 gene on the pharmacokinetic profile of anticancer drugs. Title:Association of the BCRP C421A polymorphism with nonpapillary renal cell carcinoma.|Association:Y|Conclusion:These data suggest that BCRP is a candidate RCC susceptibility gene. | Human | CXCR4 | 7852 | chemokine (C-X-C motif) receptor 4 | CXCR4/CXCL12 expression and signalling in kidney cancer | Human | VHL | 7428 | von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase | Downregulation of Cap43 gene by von Hippel-Lindau protein in renal cancer cells Title:Molecular epidemiology of VHL gene mutations in renal cell carcinoma patients: relation to dietaryand other factors.|Association:Not Found|Conclusion:The present results provide evidence that the intake of vegetables, selenium and particularly of citrus fruit protects the renal VHL gene from mutational insults that may be endogenous or common in a population. Even though most of the associations are biologically plausible, and vegetables and fruit were an a priori hypothesis, fortuitous results cannot be ruled out in this relatively small study. Quantitative differences with respect to HIF deregulation are sufficient to account for the differential risks of kidney cancer linked to VHL mutations Inactivation of the VHL gene in sporadic clear cell renal cancer (Epi)genetic alterations in the VHL gene do not have prognostic value in renal cancer prognosis Mxi1 is an important downstream target of HIF that contributes to pVHL-deficient renal cancer tumorigenesis Title:The worldwide distribution of the VHL 598C>T mutation indicates a single founding event.|Association:Y|Conclusion:We conclude that the VHL 598C>T mutation, the most common defect of congenital polycythemia yet found, was spread from a single founder 1,000 to 62,000 years ago. | Human | TNF | 7124 | tumor necrosis factor | Title:Cytokine gene polymorphisms as potential risk and protective factors in renal cell carcinoma.|Association:Not Found|Conclusion:Nevertheless, these findings suggest that the TNF-alpha -308 G/G and TGF-beta codon 10-25 T/T-G/C genotypes may be potential risk factors for RCC, whereas TNF-alpha -308 G/A, IL-6 C/C and TGF-beta1 codon 10-25 C/C-G/G genotypes may be possible protective factors. The number of the cases has to be increased to investigate the independency of these polymorphisms involved in the oncogenesis of RCC. TNF-alpha, can enhance invasion and the EMT of renal cancer cells, which provides a therapeutic target to prevent and treat advanced renal cell carcinoma | Human | TGFB1 | 7040 | transforming growth factor, beta 1 | Title:Cytokine gene polymorphisms as potential risk and protective factors in renal cell carcinoma.|Association:Not Found|Conclusion:Nevertheless, these findings suggest that the TNF-alpha -308 G/G and TGF-beta codon 10-25 T/T-G/C genotypes may be potential risk factors for RCC, whereas TNF-alpha -308 G/A, IL-6 C/C and TGF-beta1 codon 10-25 C/C-G/G genotypes may be possible protective factors. The number of the cases has to be increased to investigate the independency of these polymorphisms involved in the oncogenesis of RCC. | Human | ADAM17 | 6868 | ADAM metallopeptidase domain 17 | Highly malignant renal carcinoma cancer cells fail to form in vivo tumors in the absence of ADAM17 | Human | SMARCB1 | 6598 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 | Immunohistochemical analysis of hSNF5/INI1 gene distinguishes renal and extra-renal malignant rhabdoid tumors from other pediatric soft tissue tumors by assessing loss of INI1 expression in rhabdoid tumors | Human | SDHB | 6390 | succinate dehydrogenase complex, subunit B, iron sulfur (Ip) | Germline SDHB mutations can predispose to early-onset kidney cancers in addition to paragangliomas | Human | CXCL12 | 6387 | chemokine (C-X-C motif) ligand 12 | CXCR4/CXCL12 expression and signalling in kidney cancer | Human | ABCB1 | 5243 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 | Title:Association of the P-glycoprotein transporter MDR1(C3435T) polymorphism with the susceptibility to renal epithelial tumors.|Association:Y|Conclusion:The data provide evidence for PGP to influence the susceptibility to develop renal epithelial tumors by virtue of its MDR1(C3435T) polymorphism and changes in expression. Especially T and TT carriers are at risk for developing non-CCRCC, i.e., papillary and chromophobe RCC as well as oncocytic adenomas. | Human | PAX2 | 5076 | paired box 2 | PAX2 is a potential therapeutic gene target in renal cancer and suggest that adjunctive PAX2 knockdown may enhance the efficacy of other chemotherapeutic agents | Human | PAK1 | 5058 | p21 protein (Cdc42/Rac)-activated kinase 1 | point to Pak1 as an exciting target for therapy of renal cancer, which remains highly refractory to existing treatments | Human | MXI1 | 4601 | MAX interactor 1, dimerization protein | Mxi1 is an important downstream target of HIF that contributes to pVHL-deficient renal cancer tumorigenesis | Human | MMP3 | 4314 | matrix metallopeptidase 3 (stromelysin 1, progelatinase) | Title:Association of a haplotype of matrix metalloproteinase (MMP)-1 and MMP-3 polymorphisms with renal cell carcinoma.|Association:Y|Conclusion:These findings suggest that this haplotype of MMP-1 and MMP-3 variants may be associated with the risk of developing RCC. | Human | MMP1 | 4312 | matrix metallopeptidase 1 (interstitial collagenase) | Title:A single nucleotide polymorphism in the matrix metalloproteinase-1 promoter is associated with conventional renal cell carcinoma.|Association:Y|Conclusion:Our present data suggest that the MMP-1 promoter polymorphism may be linked to susceptibility for conventional RCC. Title:Association of a haplotype of matrix metalloproteinase (MMP)-1 and MMP-3 polymorphisms with renal cell carcinoma.|Association:Y|Conclusion:These findings suggest that this haplotype of MMP-1 and MMP-3 variants may be associated with the risk of developing RCC. | Human | LNPEP | 4012 | leucyl/cystinyl aminopeptidase | fluorimetrically analysis of membrane-bound and soluble Cystinyl aminopeptidase activity in the three main renal cancers: clear cell (CCRCC), papillary (PRCC), and chromophobe (ChRCC) renal cell carcinomas | Human | LCK | 3932 | lymphocyte-specific protein tyrosine kinase | Loss of expression of lymphocyte-specific protein tyrosine kinase lck is associated with tumor-infiltrating lymphocytes in renal cancer | Human | IL15 | 3600 | interleukin 15 | Constitutive and IFN-gamma regulated expression of IL-7 and IL-15 in human renal cell cancer. |
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