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Genes (16)
Species: human : 15 mouse : 1 | |
Mouse | ID2 | 3398 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | The class 2 phenotype could be recapitulated by eliminating Id2 in cultured class 1 human uveal melanoma cells and in a mouse ocular melanoma model. | Human | MAGEA2B | 266740 | melanoma antigen family A, 2B | We conclude that cultured ocular melanoma cell lines express MAGE-1, MAGE-2, and MAGE-3 genes. Our results demonstrate that MAGE-1, MAGE-2, and MAGE-3 genes are transcribed in primary ocular melanoma cell lines and are detected in cells recovered from 41, 53, and 53% of the patients examined, respectively. | Human | MAGED4B | 81557 | melanoma antigen family D, 4B | Our results demonstrate that MAGE-1, MAGE-2, and MAGE-3 genes are transcribed in primary ocular melanoma cell lines and are detected in cells recovered from 41, 53, and 53% of the patients examined, respectively. We conclude that cultured ocular melanoma cell lines express MAGE-1, MAGE-2, and MAGE-3 genes. | Human | PXDN | 7837 | peroxidasin homolog (Drosophila) | By quantitative reverse transcription, MG50 message was found in one of two skin melanoma cell lines, an ocular melanoma cell line, two of four metastatic skin melanomas, two of three mammary carcinomas, one of two colon carcinomas, and an ovarian carcinoma. | Human | CIITA | 4261 | class II, major histocompatibility complex, transactivator | Epigenetic silencing of the CIITA gene and posttranscriptional regulation of class II MHC genes in ocular melanoma cells. | Human | MC1R | 4157 | melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) | Our findings argue against an important predisposing effect of the MC1R and CDKN2A genes for ocular melanoma. Ocular melanoma is not associated with CDKN2A or MC1R variants--a population-based study. | Human | MAGEA2 | 4101 | melanoma antigen family A, 2 | We conclude that cultured ocular melanoma cell lines express MAGE-1, MAGE-2, and MAGE-3 genes. Our results demonstrate that MAGE-1, MAGE-2, and MAGE-3 genes are transcribed in primary ocular melanoma cell lines and are detected in cells recovered from 41, 53, and 53% of the patients examined, respectively. | Human | MAGEA1 | 4100 | melanoma antigen family A, 1 (directs expression of antigen MZ2-E) | Our results demonstrate that MAGE-1, MAGE-2, and MAGE-3 genes are transcribed in primary ocular melanoma cell lines and are detected in cells recovered from 41, 53, and 53% of the patients examined, respectively. We conclude that cultured ocular melanoma cell lines express MAGE-1, MAGE-2, and MAGE-3 genes. | Human | KIT | 3815 | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | Potential use of imatinib mesylate in ocular melanoma and liposarcoma expressing immunohistochemical c-KIT (CD117). | Human | KDR | 3791 | kinase insert domain receptor (a type III receptor tyrosine kinase) | The immunolocalization and gene expression of vascular endothelial growth factor (VEGF) and its cognate tyrosine kinase receptors, Flt-1 and KDR, has been studied in ocular melanomas and retinoblastomas using in situ hybridization and immunohistochemistry. | Human | FLT1 | 2321 | fms-related tyrosine kinase 1 | The immunolocalization and gene expression of vascular endothelial growth factor (VEGF) and its cognate tyrosine kinase receptors, Flt-1 and KDR, has been studied in ocular melanomas and retinoblastomas using in situ hybridization and immunohistochemistry. | Human | CD80 | 941 | CD80 molecule | Gene transfer of the CD80 costimulatory molecule into ocular melanoma cells using a novel episomal vector. CD80+ ocular melanoma cells maintained a stable CD80 expression even after prolonged culture without geneticin, and on irradiated tumor cells. We evaluated the influence of CD80 expression on the immunostimulatory activity of ocular melanoma cell lines and determined whether IFN-gamma could enhance the effect. Two ocular melanoma cell lines were transfected with CD80 cDNA. CONCLUSIONS: The B45-Neo episomal vector induces stable expression of the CD80 costimulatory molecule on ocular melanoma cells. SUM159PT mammary carcinoma and Mel 202 ocular melanoma cells transduced with the retroviruses DRB1/CD80 express high levels of DRB0101 and CD80 on the cell surface in the absence of Ii. In this study, primary human ocular melanoma cells were transfected with a novel vector (B45-Neo episomal vector) containing the complementary DNA (cDNA) for human CD80 to determine if this vector system is useful for stimulating CD8+ T cells. METHODS: Ocular melanoma cells were transfected with the B45-Neo episomal vector containing the cDNA for human CD80 and were positively selected in medium containing geneticin. | Human | BRCA2 | 675 | breast cancer 2, early onset | An association between ocular melanoma and breast and/or ovarian cancer has also been reported and recent studies of breast cancer families strongly implicate BRCA2 as a predisposition gene. Germline brca2 sequence variants in patients with ocular melanoma. We studied the BRCA2 gene for germline mutations in 71 of 99 patients (72%) with ocular melanoma who were diagnosed consecutively in Australia in 1997 and 1998. BRCA2 mutations in a population-based series of patients with ocular melanoma. We estimated the prevalence of possible loss of function changes in BRCA2 in patients with ocular melanoma at 3% (95% CI 0-10%). On the basis, chiefly, of anecdotal reports of cases of ocular melanoma (OM) occurring in families with inherited susceptibility to breast cancer due to brca2 germline mutations, we examined the frequency of brca2 alterations in a series of 62 ocular melanoma cases. | Human | BMP6 | 654 | bone morphogenetic protein 6 | BMP-6 expression was detected in the prostate tissue of over 50% of patients with clinically defined metastatic prostate adenocarcinoma, but was not detected in non-metastatic or benign prostate samples or in ocular melanoma tissue. | Human | AXL | 558 | AXL receptor tyrosine kinase | Expression of the receptor tyrosine kinase Axl promotes ocular melanoma cell survival. | Human | AMH | 268 | anti-Mullerian hormone | Recombinant human mullerian inhibiting substance inhibits human ocular melanoma cell lines in vitro and in vivo. |
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