Human | MAP1LC3A | 84557 | microtubule-associated protein 1 light chain 3 alpha | LC3 is upregulated in various gastrointestinal cancers and partly associated with Ki-67 inde; results suggest that LC3 expression is advantageous to cancer development especially in early-phase carcinogenesis |
Human | PPP1R1B | 84152 | protein phosphatase 1, regulatory (inhibitor) subunit 1B | Darpp-32: a novel antiapoptotic gene in upper gastrointestinal carcinomas. |
Human | UGT1A7 | 54577 | UDP glucuronosyltransferase 1 family, polypeptide A7 | most of the previously reported genetic associations between UGT1A7 and gastrointestinal cancers are based on primer-dependent genotyping errors |
Human | KRT20 | 54474 | keratin 20 | It is possible to apply a simple and reliable method for the detection of circulating tumor cells based on cytokeratin-20 and prostate stem cell antigen RT-PCR assays in gastrointestinal cancers |
Human | PKP3 | 11187 | plakophilin 3 | qRT-PCR assay targeted to plakophilin 3 and anterior gradient-2 mRNAs might be helpful to detect circulating tumor cells in patients with gastrointestinal cancer |
Human | PRDM5 | 11107 | PR domain containing 5 | Data suggest that epigenetic alteration of PRDM5 (e.g., methylation of its 5'-CpG island or trimethylation of Lys(27) of histone H3) likely plays a key role in the progression of gastrointestinal cancers and may be a useful molecular marker |
Human | FADD | 8772 | Fas (TNFRSF6)-associated via death domain | This is the first report of FADD gene mutation in gastrointestinal cancers, and data suggest that the FADD gene is rarely mutated in human colon and stomach cancers |
Human | CXCR4 | 7852 | chemokine (C-X-C motif) receptor 4 | Here we investigate the expression of CXCR4 mRNA expression in several digestive tract cancers and hepatitis C viral (HCV) infected liver, a premalignant condition. We have recently demonstrated by Northern blot and RT-PCR that the mRNA expression of the alpha-chemokine hIRH/SDF-1alpha is reduced in hepatocellular carcinoma (HCC), several digestive tract cancers and premalignant colon adenomas, and that its receptor CXCR4 mRNA expression is reduced in HCC. |
Human | PXDN | 7837 | peroxidasin homolog (Drosophila) | Quantitative real-time reverse transcription-PCR results of selected genes, including PXN, KRT8, and ITGB5, were correlated to microarray data and successfully discriminate the gastrointestinal tract cancer cell lines from hematologic malignant cell lines. Quantitative real-time reverse transcription-PCR results of selected genes, including PXN, KRT8, and ITGB5, were correlated to microarray data and successfully discriminate the gastrointestinal tract cancer cell lines from hematologic malignant cell lines.CONCLUSIONS: A gene expression database could serve as a useful source for the further investigation of cancer biology using the cell lines. |
Human | ZNF148 | 7707 | zinc finger protein 148 | ZBP-89 induces apoptosis in human gastrointestinal cancer cells through a p53-independent mechanism. |
Human | WNT2 | 7472 | wingless-type MMTV integration site family member 2 | REVIEW: role in human gastrointestinal cancer |
Human | UCHL1 | 7345 | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) | Epigenetic inactivation of UCHL1 is common in primary hepatocellular carcinomas(HCCs) and other digestive tumors and appears to be functional tumor suppressor involved in tumorigenesis of HCCs and other digestive cancers |
Human | ST14 | 6768 | suppression of tumorigenicity 14 (colon carcinoma) | The expressions of SNC19/matriptase and its inhibitor HAI-1 are decreased in gastrointestinal cancer tissues |
Human | SPINT1 | 6692 | serine peptidase inhibitor, Kunitz type 1 | The expressions of SNC19/matriptase and its inhibitor HAI-1 are decreased in gastrointestinal cancer tissues |
Human | HLTF | 6596 | helicase-like transcription factor | Methylation pattern of HLTF gene in digestive tract cancers. |
Human | PDGFRA | 5156 | platelet-derived growth factor receptor, alpha polypeptide | Title:Deletions affecting codons 557-558 of the c-KIT gene indicate a poor prognosis in patients with completely resected gastrointestinal stromal tumors: a study by the Spanish Group for SarcomaResearch (GEIS).|Association:Not Found|Conclusion:Deletions affecting codons 557 to 558 are relevant for the prognosis of RFS in GIST patients. This critical genetic alteration should be considered to be a new prognostic stratification variable for randomized trials exploring imatinib mesylate in the adjuvant setting in GIST patients. |
Human | CEACAM6 | 4680 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | SUMMARY BACKGROUND DATA: Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) is widely overexpressed in human gastrointestinal cancer. |
Human | MUC2 | 4583 | mucin 2, oligomeric mucus/gel-forming | careful systemic surveillance is needed to detect coexisting gastrointestinal cancer for subtypes of intraductal papillary mucinous neoplasms with MUC2 expression |
Human | MSH2 | 4436 | mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) | The odds ratio (OR) was 8.76 for CRC and 9.15 for GC, suggesting an association between the presence of variants in exon 7 of the MSH2 gene and risk of gastrointestinal cancer in the studied population |
Human | MLH1 | 4292 | mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) | This work availably evaluated the functional consequences of some missense mutations not previously determined in the hMLH1 gene and might be useful for the clinical diagnosis of hereditary gastrointestinal cancer, especially in East Asians |
Human | CIITA | 4261 | class II, major histocompatibility complex, transactivator | CIITA methylation is a key mechanism that enables some gastrointestinal cancer cells to escape immune surveillance |
Human | MDK | 4192 | midkine (neurite growth-promoting factor 2) | Increased midkine gene expression in human gastrointestinal cancers. |
Human | MAGEA3 | 4102 | melanoma antigen family A, 3 | The newly identified MAGE-3(113)-peptide epitope is naturally processed and presented as the CTL epitope on MAGE-3-expressing GI cancer cells, indicating that anti-MAGE-3 immune targeting with the MAGE-3(113) peptide is a promising approach for treatment |
Human | MAD2L1 | 4085 | MAD2 mitotic arrest deficient-like 1 (yeast) | Therefore, we investigated the mutational status of the hsMAD2 and hBUB1 genes in 32 sporadic digestive tract cancers by reverse transcription-polymerase chain reaction-single strand conformation polymorphism analysis. Mutational inactivation of mitotic checkpoint genes, hsMAD2 and hBUB1, is rare in sporadic digestive tract cancers. |
Human | ITGB5 | 3693 | integrin, beta 5 | Quantitative real-time reverse transcription-PCR results of selected genes, including PXN, KRT8, and ITGB5, were correlated to microarray data and successfully discriminate the gastrointestinal tract cancer cell lines from hematologic malignant cell lines. Quantitative real-time reverse transcription-PCR results of selected genes, including PXN, KRT8, and ITGB5, were correlated to microarray data and successfully discriminate the gastrointestinal tract cancer cell lines from hematologic malignant cell lines.CONCLUSIONS: A gene expression database could serve as a useful source for the further investigation of cancer biology using the cell lines. |