Human | IRGM | 345611 | immunity-related GTPase family, M | Genetic evidence implicates IRGM defects in the early immune response in individuals with Crohn's disease IRGM is significantly associated with Crohn disease This study has confirmed NCF4 and IRGM are risk factors for ileal Crohn's disease in New Zealand Caucasians |
Human | CCNY | 219771 | cyclin Y | Single nucleotide polymorphism in CCNY gene is associated with Crohn's disease and ulcerative colitis |
Human | PSORS1C1 | 170679 | psoriasis susceptibility 1 candidate 1 | SEEK1 polymorphisms +39604, +39709, and +26680 are not associated with Crohn's disease in the Newfoundland population |
Human | NKX2-3 | 159296 | | Single nucleotide polymorphism in NKX2-3 gene is associated with Crohn's disease and ulcerative colitis |
Human | IL23R | 149233 | interleukin 23 receptor | Click here to display 15 evidence detail records. |
Human | NLRP3 | 114548 | NLR family, pyrin domain containing 3 | significant KPNA1-, NLRP1- and NLRP3-gene expression phenotypes associated with human genotypes of Crohn's disease, Huntington's disease and rheumatoid arthritis These results suggest that the NLRP3 region is also implicated in the susceptibility of more common inflammatory diseases such as Crohn's disease |
Human | C13orf23 | 80209 | | Genomic regions have been identified demonstrating significant evidence for single nucleotide polymorphism linkage to Crohn's disease on chromosomes 16q12.1 and 13q13.3, and suggestive evidence for linkage to ulcerative colitis on chromosome 19p12 |
Human | NOD2 | 64127 | nucleotide-binding oligomerization domain containing 2 | Click here to display 99 evidence detail records. |
Human | IL21 | 59067 | interleukin 21 | REVIEW:IL-21 is highly produced by activated CD4+ lymphocytes in the inflamed gut of patients with Crohn's disease, where it contributes to sustaining the ongoing Th1 inflammation |
Human | CXCL16 | 58191 | chemokine (C-X-C motif) ligand 16 | in Crohn's disease (CD), the CXCL16 p.Ala181Val polymorphism is not a disease susceptibility gene but associated with younger age at disease onset and higher frequency of ileal involvement |
Human | BTNL2 | 56244 | butyrophilin-like 2 (MHC class II associated) | a major effect of the BTNL2 rs2076530 (G --> A) SNP in Crohn's disease and tuberculosis was excluded; there was an association with susceptibility to leprosy (P=0.04), however, this is most likely due to linkage disequilibrium with HLA-DR Does not contribute to susceptibility to Crohn's disease in Japan but is associated with Japanese ulcerative colitis because of strong linkage disequilibrium with HLA-DRB1*1502 |
Human | ITLN1 | 55600 | intelectin 1 (galactofuranose binding) | Omentin might be a new adipocytokine playing a role in the defense against intestinal bacterial translocation in the context of Crohn's disease |
Human | ATG16L1 | 55054 | autophagy related 16-like 1 (S. cerevisiae) | Click here to display 10 evidence detail records. |
Human | TLR9 | 54106 | toll-like receptor 9 | TLR9 variants were not major risk factors for Crohn's disease in New Zealand population, but may associations with disease worldwide |
Human | GHRL | 51738 | ghrelin/obestatin prepropeptide | The dysregulation of reactivity of T cells induced by ghrelin is associated with the pathogenesis of Crohn's disease |
Human | IL23A | 51561 | interleukin 23, alpha subunit p19 | intestinal macrophages expressing CD14 contribute to the pathogenesis of Crohn disease via IL-23/IFN-gamma axis |
Human | IBD5 | 50941 | inflammatory bowel disease 5 | Click here to display 5 evidence detail records. |
Human | IL22 | 50616 | interleukin 22 | IL-22 is increased in active Crohn's disease and promotes proinflammatory gene expression and IEC migration IL-21 contributes to the ongoing Th1 mucosal response in Crohn's disease |
Human | CD209 | 30835 | CD209 molecule | Increased expression of DC-SIGN+IL-12+IL-18+ and CD83+IL-12-IL-18- dendritic cell populations in the colonic mucosa of patients with Crohn's disease |
Human | PTPN22 | 26191 | protein tyrosine phosphatase, non-receptor type 22 (lymphoid) | the 620W allele of protein tyrosine phosphatase PTPN22 does not play a major role in Crohn's disease and multiple sclerosis |
Human | KLRK1 | 22914 | killer cell lectin-like receptor subfamily K, member 1 | Role of MICA-NKG2D in activation of unique subset of CD4(+) T cells with inflammatory and cytotoxic properties in Crohn's disease |
Human | CARD8 | 22900 | caspase recruitment domain family, member 8 | no significant association between the risk allele "A" at Cys10Stop and risk for Crohn's disease or ulcerative colitis was detected in patients of German and Norwegian descent association between a likely functional polymorphism in TUCAN and Crohn disease |
Human | NLRP1 | 22861 | NLR family, pyrin domain containing 1 | significant KPNA1-, NLRP1- and NLRP3-gene expression phenotypes associated with human genotypes of Crohn's disease, Huntington's disease and rheumatoid arthritis |
Human | IRAK3 | 11213 | interleukin-1 receptor-associated kinase 3 | no evidence to suggest association between inflammatory bowel disease, Crohn's disease (CD), ulcerative colitis (UC) or subsets of CD & UC and IRAK-M; an interaction was found between IRAK-M and CARD15 in UC patients |
Human | MASP2 | 10747 | mannan-binding lectin serine peptidase 2 | variations in MASP2 appear to be of limited importance in the pathogenesis of Crohn's disease |