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Genes (540)
Species: human : 502 mouse : 38 | |
Mouse | HIST1H2AA | 221613 | histone cluster 1, H2aa | First, histone H2A-mediated transfection of IL-2 induces a natural killer cell-induced rejection of primary tumors in contrast to Superfect, which produces only a partial reduction in primary tumor growth. | Mouse | BRMS1 | 25855 | breast cancer metastasis suppressor 1 | Transfection with brms1 did not inhibit 66cl4 primary tumor formation but significantly suppressed its metastatic capability. | Mouse | PIM2 | 11040 | pim-2 oncogene | In primary tumors integration near pim-2 is usually undetectable or present in only a minor fraction of the tumor cells. | Mouse | FRAT1 | 10023 | frequently rearranged in advanced T-cell lymphomas | The initial selection for integrations near Frat1 occurs in primary tumor cells that have already acquired proviruses in other common insertion sites, yielding primary lymphomas that contain only a minor fraction of tumor cells with an activated Frat1 allele. | Mouse | BCL2L11 | 10018 | BCL2-like 11 (apoptosis facilitator) | None of the primary tumors from Bim(+/-) Emicro-Myc mice displayed loss of the second allele of Bim. | Mouse | DLEC1 | 9940 | deleted in lung and esophageal cancer 1 | Promoter hypermethylation of DLEC1 was also detected in 30 of 42 (71%) NPC primary tumors. | Mouse | CLDN2 | 9075 | claudin 2 | Using a panel of genes identified by suppression subtractive hybridization of cDNAs from individual primary tumours and a metastasis, some cDNAs were found to exhibit a differential pattern of expression associated with the expression of S100A4 protein (including osteopontin, S100A9, claudin 2 and several Expressed Sequence Tags sequences). | Mouse | WISP1 | 8840 | WNT1 inducible signaling pathway protein 1 | Microarray analysis defined seven genes, namely - arginase, brain natriuretic peptide (BNP), interleukin-1 alpha (IL-1 alpha), plasminogen activator inhibitor-2 (PAI-2), surfactant protein C (SP-C), uteroglobin (UG) and wnt-1-induced secreted protein-1 (WISP-1), which were consistently elevated in pulmonary metastases compared to the primary tumour of both D122 and B16-F10.9 models. | Mouse | TNXB | 7148 | tenascin XB | The primary tumor size in TNX - / - TNC + / + mice was significantly larger than that in wild-type mice, but those of TNX + / + TNC - / - and double knockout mice were comparable to that in the wild-type mice. | Mouse | TSPAN8 | 7103 | tetraspanin 8 | When orthotopically implanted, the size of the primary tumor in the liver did not differ between CO-029 and the mock transfectants. | Mouse | TIMP2 | 7077 | TIMP metallopeptidase inhibitor 2 | Significant inhibition of primary tumor growth was obtained with TAM (40% inhibition, P=0.049), angiostatin (85% inhibition, P=0.001) and TIMP-2 (60% inhibition, P=0.015). The association of angiostatin, TIMP-2 and TAM was greatly effective at the primary tumor level (90% inhibition, P=0.01). | Mouse | TIMP1 | 7076 | TIMP metallopeptidase inhibitor 1 | The TIMP-1 transfectants had a significantly greater inhibitory effect, in association with TIMP-1 expression, on the growth of the primary tumor and on liver metastasis as compared with the controls. | Mouse | SPARC | 6678 | secreted protein, acidic, cysteine-rich (osteonectin) | Finally, as compared with cells before passage in animals, thrombospondin-1, SPARC, and VEGF gene expression was also deregulated in cell lines isolated from primary tumors induced by BPV1-transformants. | Mouse | S100A9 | 6280 | S100 calcium binding protein A9 | Using a panel of genes identified by suppression subtractive hybridization of cDNAs from individual primary tumours and a metastasis, some cDNAs were found to exhibit a differential pattern of expression associated with the expression of S100A4 protein (including osteopontin, S100A9, claudin 2 and several Expressed Sequence Tags sequences). | Mouse | S100A4 | 6275 | S100 calcium binding protein A4 | The Mts1 protein was detected in the transgene primary tumor cells as well as in the corresponding metastases. | Mouse | PGD | 5226 | phosphogluconate dehydrogenase | It was found that a clear relationship exists between activity and the number of chromosome 1p for PGD but not for UMPK, both on primary tumors (PTs) and on tumors grafted into nude mice (GTs). | Mouse | NOTCH2 | 4853 | notch 2 | These results represent the first reported instance for the involvement of Notch2 inactivation in the development of thymic primary tumours while confirming the role of Notch1 as an activated oncogene. | Mouse | NOTCH1 | 4851 | notch 1 | In the current study, we found that 13 of 19 cell lines and 29 of 49 primary tumors from SCL/LMO1, OLIG2/LMO1, OLIG2, LMO1, NUP98/HOXD13, and p27(-/-)/SMAD3(+/-) mice had Notch1 mutations in either the heterodimerization (HD) or the glutamic acid/serine/threonine (PEST) domain but not both. These results represent the first reported instance for the involvement of Notch2 inactivation in the development of thymic primary tumours while confirming the role of Notch1 as an activated oncogene. | Mouse | NOS3 | 4846 | nitric oxide synthase 3 (endothelial cell) | Findings using clonal derivatives supported this notion; s.c. primary tumour growth rate, efficiency of spontaneous metastasis and eNOS expression were higher for C3L5 relative to C10 cell lines. A heterogeneous pattern of endothelial NOS (eNOS) expression was observed in tumour cells in spontaneous primary tumours, and eNOS expression was higher in undifferentiated relative to differentiated tumour zones. | Mouse | NME1 | 4830 | NME/NM23 nucleoside diphosphate kinase 1 | RESULTS: In both models, Nm23-M1 and/or Nm23-M2 were overexpressed in the primary liver tumors compared with nontumor liver tissue; however, the lack of the NM23-M1 gene had no effect on primary tumor formation in either model. Expression of Nm23 protein isoforms (Nm23-M1 and Nm23-M2) and several tumor markers was analyzed in the primary tumor and in metastases by Western blotting. | Mouse | MMP12 | 4321 | matrix metallopeptidase 12 (macrophage elastase) | Click here to display 8 evidence detail records. | Mouse | MCM7 | 4176 | minichromosome maintenance complex component 7 | Indeed, MCM7 overexpression produced primary tumors 12 times larger than vector-only controls and resulted in a rapid demise of mice bearing those tumors. | Mouse | LOX | 4015 | lysyl oxidase | Using this system, we isolated and sequenced a cDNA fragment that encoded mouse lysyl oxidase (LO) and was induced by transforming growth factor-beta1 in primary tumor but not in metastasis-derived cells. | Mouse | LAG3 | 3902 | lymphocyte-activation gene 3 | Co-administration of soluble LAG-3 with wild-type tumor cells also markedly reduced primary tumor growth. | Mouse | IL15 | 3600 | interleukin 15 | We have demonstrated elevated expression levels of NF-kappa B--inducible cytokines, including interleukin (IL)-6, IL-10, IL-15, and interferon (IFN)-gamma, in freshly isolated primary tumors from Tax transgenic mice. |
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