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Genes (20)
Species: human : 20 | |
Human | LY6D | 8581 | lymphocyte antigen 6 complex, locus D | Monoclonal antibody (MAb) E48 and its F(ab;)2 fragment, radiolabelled with 131I, were tested for tumour localisation and imaging in nude mice bearing a squamous cell carcinoma xenograft line derived from a head and neck carcinoma (HNX-HN) or from a vulva carcinoma (VX-A431). | Human | WRN | 7486 | Werner syndrome, RecQ helicase-like | The 1396del A mutation and a missense mutation or a rare polymorphism of the WRN gene detected in a French Werner family with a severe phenotype and a case of an unusual vulvar cancer. The 1396del A mutation and a missense mutation or a rare polymorphism of the WRN gene detected in a French Werner family with a severe phenotype and a case of an unusual vulvar cancer. | Human | TP53 | 7157 | tumor protein p53 | p53 mutations are a later event in vulvar carcinoma | Human | RBL2 | 5934 | retinoblastoma-like 2 (p130) | The significant progressive decrease of pRB2/p130 expression from non-neoplastic epithelial alterations through intraepithelial neoplasia to invasive vulvar carcinomas suggests a role for this tumor suppressor gene in vulvar carcinogenesis. Our data indicate that loss of pRB2/p130 and p27kip1 are frequent events in invasive vulvar carcinomas compared with synchronous premalignant lesions, non-neoplastic epithelial disorders, and normal vulvar skin. | Human | PTGS2 | 5743 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | In this test set, cyclooxygenase 2 and Caspase 3 seem to be immunohistochemical markers with prognostic significance for vulva cancer Vulvar cancer in elderly patients may be associated with inflammation, and thus with increased COX-2 expression | Human | NOS3 | 4846 | nitric oxide synthase 3 (endothelial cell) | Title:Polymorphisms of the endothelial nitric oxide synthase gene in women with vulvar cancer.|Association:Y|Conclusion:We are the first to report on NOS3 polymorphisms in vulvar cancer. We found that allelic variation within intron 4, but not ithin exon 7 of NOS3, influences the length of disease-free survival, but not the biological phenotype of vulvar cancer. | Human | MSH2 | 4436 | mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) | There is increased expression of MSH2 in vulvar carcinoma neoplasms | Human | MMP13 | 4322 | matrix metallopeptidase 13 (collagenase 3) | MMP-13 expression was especially abundant in vulvar carcinomas showing metastasis to lymph nodes and was associated with expression of membrane type 1 MMP by tumor cells and gelatinase-A (MMP-2) by stromal cells, as detected by immunohistochemistry. MMP-13 mRNAs were detected in 9 of 11 cell lines established from vulvar carcinomas and in 4 of 6 cell lines from cervical carcinomas, whereas endometrial (n = 10) and ovarian (n = 9) carcinoma cell lines were negative for MMP-13 mRNA. | Human | MLH1 | 4292 | mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) | There is increased expression of MLH1 in vulvar carcinoma neoplasms | Human | KRT13 | 3860 | keratin 13 | We isolated two different cDNA clones from the vulvar carcinoma cell line A-431, in which this protein is abundant: One clone seems to represent the entire mRNA, whereas the other is only a minor component and encodes a truncated cytokeratin 13 lacking most of the carboxy-terminal tail domain, probably a product of alternative, ;incorrect; splicing. | Human | JUN | 3725 | jun proto-oncogene | The binding activity of NF-kappaB was found to be stimulated by TNF-alpha in both vulvar carcinoma cell lines while no effect on AP-1 was found by any of the cytokines. The aim of this study was to investigate the effect of growth-inhibitory cytokines on the binding activity of transcription factor AP-1 and NF-kappaB in two vulvar carcinoma cell lines UM-SCV-6 and UM-SCV-1A in vitro. | Human | IVL | 3713 | involucrin | METHODS. The expression of several differentiation markers, i.e., cytokeratin (CK) 10, CK 13, and involucrin, was studied in samples of 41 vulvar carcinomas. | Human | IL6 | 3569 | interleukin 6 (interferon, beta 2) | Title:A Common Interleukin-6 Promoter Polymorphism in Patients With Vulvar Cancer.|Association:Not Found|Conclusion:Our data suggest that the IL6 -174(G-->C) promoter polymorphism might serve as an additional prognostic parameter in patients with vulvar cancer. | Human | IL1RN | 3557 | interleukin 1 receptor antagonist | RESULTS: Presence of the minor allele of the IL1RN polymorphism was found to be protective for vulvar cancer [odds ratio (OR)=0.5, P=0.03], the other investigated polymorphisms showed no association with the disease and the investigated clinicopathological parameters. Title:A polymorphism of the interleukin-1 receptor antagonist plays a prominent role within the interleukin-1 gene cluster in vulvar carcinogenesis.|Association:Y|Conclusion:We are the first to report on polymorphisms in genes encoding cytokines in patients with vulvar cancer. Reflecting its biological role, the common IL1RN intron 2 polymorphism seems to play a prominent role within the IL-1 gene cluster with respect to vulvar carcinogenesis. | Human | IL1B | 3553 | interleukin 1, beta | Title:A polymorphism of the interleukin-1 receptor antagonist plays a prominent role within the interleukin-1 gene cluster in vulvar carcinogenesis.|Association:Not Found|Conclusion:We are the first to report on polymorphisms in genes encoding cytokines in patients with vulvar cancer. Reflecting its biological role, the common IL1RN intron 2 polymorphism seems to play a prominent role within the IL-1 gene cluster with respect to vulvar carcinogenesis. | Human | IL1A | 3552 | interleukin 1, alpha | Title:A polymorphism of the interleukin-1 receptor antagonist plays a prominent role within the interleukin-1 gene cluster in vulvar carcinogenesis.|Association:Not Found|Conclusion:We are the first to report on polymorphisms in genes encoding cytokines in patients with vulvar cancer. Reflecting its biological role, the common IL1RN intron 2 polymorphism seems to play a prominent role within the IL-1 gene cluster with respect to vulvar carcinogenesis. | Human | FGF4 | 2249 | fibroblast growth factor 4 | The HST1 gene was found to be amplified in DNAs obtained from a stomach cancer and a vulvar carcinoma cell line, A431. | Human | CRP | 1401 | C-reactive protein, pentraxin-related | CRP serum levels are closely associated with lymph node status but cannot be used as prognostic parameter in patients with vulvar cancer | Human | CDKN1B | 1027 | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | Expression of p27Kip1 is downregulated while oxidative DNA damage increases from early non-neoplastic epithelial alterations through vulvar intraepithelial neoplasias to invasive vulvar carcinomas | Human | CA9 | 768 | carbonic anhydrase IX | potential value of CA9 as a molecular marker for the assessment of regional lymph node status in vulvar cancer patients |
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