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Details
Link-It Detail - Disease - Manganese Poisoning
Debug Stats
  • ### Total Build Time: 51 ms 27.059 KB
  • CONCEPT_NAME gt=3 ms Completed: 3 ms rowSize= 336 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 501 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
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  • CONCEPT_PARENTS gt=3 ms Completed: 3 ms rowSize= 1,000 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=2 ms Completed: 2 ms rowSize= 4.090 KB
  • CONCEPT_RELATIONSHIPS gt=33 ms Completed: 33 ms rowSize= 12.978 KB
  • CONCEPT_GENES gt=7 ms Completed: 7 ms rowSize= 6.825 KB
  • CONCEPT_XREFS gt=3 ms Completed: 3 ms rowSize= 1.153 KB
  • CONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Manganese Poisoning C0677050
Definition (1)
Manganese poisoning is associated with chronic inhalation of manganese particles by individuals who work with manganese ore. Clinical features include CONFUSION; HALLUCINATIONS; and an extrapyramidal syndrome (PARKINSON DISEASE, SECONDARY) that includes rigidity; DYSTONIA; retropulsion; and TREMOR. (Adams, Principles of Neurology, 6th ed, p1213)
Semantic Types (1)
Injury or Poisoning (T037)
Parents (2)
img Poisoning C0032343
img Heavy Metal Poisoning, Nervous System C0751850
Ancestral Roots
RootRoot Plus OneDepthParent
img Mental Disorders C0004936img Substance-Related Disorders C02369694img Poisoning C0032343
img Mental Disorders C0004936img Substance-Related Disorders C02369696img Heavy Metal Poisoning, Nervous System C0751850
img Nervous System Diseases C0027765img Neurotoxicity Syndromes C02350324img Heavy Metal Poisoning, Nervous System C0751850
Relationships (31)

Relation Types:
diso_​to_​anat : 6
diso_​to_​chem : 11
diso_​to_​diso : 14


Relationships:
none : 19
associated_​with : 2
induces : 1
isa : 1
location_​of : 1
may_​treat : 5
permuted_​term_​of : 1
used_​for : 1
Page Size
Current 25
  Page 1 of 2
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_CHEM42img Manganese C0024706
DISO_to_CHEM35img Manganese C0024706
DISO_to_DISO22img Complication Aspects C1171258
DISO_to_DISO22img EXPOSURE OCCUP C0028798
DISO_to_DISO21img Complication Aspects C1171258
DISO_to_DISO16img DIS OCCUP C0028797
DISO_to_DISO14img Occupational Exposure C0028798
DISO_to_ANAT13img Brain C0006104
DISO_to_ANAT13img In Blood C0005768
DISO_to_CHEM9img Manganese Compounds C0206374
DISO_to_DISO9img DIS OCCUP C0028797
DISO_to_ANAT8img In Blood C0005768
DISO_to_ANAT8img Neurons C0027882
DISO_to_DISO8img Environmental Exposure C0014412
DISO_to_ANAT7img Astrocytes C0004112
DISO_to_CHEM7img Propiophenones C0033483
DISO_to_DISO7img Inhalation Exposure C0524800
DISO_to_DISO7img Parkinson Disease, Secondary C0030569
DISO_to_DISO7img Parkinsonian Disorders C0242422
DISO_to_ANATlocation_ofimg Lung C0024109
DISO_to_CHEMmay_treatimg DISODIUM EDTA C0012695
DISO_to_CHEMmay_treatimg EDETATE CA DISODIUM 200MG/ML INJ C0357218
DISO_to_CHEMmay_treatimg EDETATE DISODIUM 150 MG INTRAVENOUS INJECTION C1591208
DISO_to_CHEMinducesimg MANGANESE (AS CHLORIDE) C0065642
DISO_to_CHEMassociated_withimg Manganese C0024706
Genes (5)

Species:
human : 5
SpeciesGeneGeneIdGene NameEvidence
HumanGSTT12952glutathione S-transferase theta 1
img GAD, Score=1000, Pubmed Id: 12171760, UMLKSK CUI: C0677050
HumanNQO11728NAD(P)H dehydrogenase, quinone 1
img GAD, Score=1000, Pubmed Id: 12171760, UMLKSK CUI: C0677050
HumanCYP2D61565cytochrome P450, family 2, subfamily D, polypeptide 6
img GENERIF, Score=694, Pubmed Id: 12171760, UMLKSK CUI: C0677050
HumanCYP2D7P11564cytochrome P450, family 2, subfamily D, polypeptide 7 pseudogene 1
img GAD, Score=1000, Pubmed Id: 12171760, UMLKSK CUI: C0677050
HumanCYP1A11543cytochrome P450, family 1, subfamily A, polypeptide 1
img GAD, Score=1000, Pubmed Id: 12171760, UMLKSK CUI: C0677050
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0677050Manganese Poisoning0self