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Details
Link-It Detail - Disease - Activated Protein C Resistance
Debug Stats
  • ### Total Build Time: 35 ms 29.842 KB
  • CONCEPT_NAME gt=3 ms Completed: 3 ms rowSize= 358 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 420 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=1 ms Completed: 1 ms rowSize= 198 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=4 ms Completed: 4 ms rowSize= 1.419 KB
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=8 ms Completed: 8 ms rowSize= 5.436 KB
  • CONCEPT_RELATIONSHIPS gt=7 ms Completed: 7 ms rowSize= 6.594 KB
  • CONCEPT_GENES gt=8 ms Completed: 8 ms rowSize= 14.241 KB
  • CONCEPT_XREFS gt=3 ms Completed: 3 ms rowSize= 1.164 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Activated Protein C Resistance C0600433
Definition (1)
A hemostatic disorder characterized by a poor anticoagulant response to activated protein C (APC). The activated form of Factor V (Factor Va) is more slowly degraded by activated protein C. Factor V Leiden mutation (R506Q) is the most common cause of APC resistance.
Semantic Types (1)
Cell or Molecular Dysfunction (T049)
Parents (3)
img Coagulation Protein Disorders C0600503
img Blood Coagulation Disorders, Inherited C0852077
img Thrombophilia C0398623
Ancestral Roots
RootRoot Plus OneDepthParent
img Hemic and Lymphatic Diseases C0018981img Hematologic Diseases C00189395img Coagulation Protein Disorders C0600503
img Congenital, Hereditary, and Neonatal Diseases and Abnormalities C0027612img Genetic Diseases, Inborn C09501234img Blood Coagulation Disorders, Inherited C0852077
img Hemic and Lymphatic Diseases C0018981img Hematologic Diseases C00189395img Blood Coagulation Disorders, Inherited C0852077
img Hemic and Lymphatic Diseases C0018981img Hematologic Diseases C00189394img Thrombophilia C0398623
Relationships (15)

Relation Types:
diso_​to_​anat : 2
diso_​to_​chem : 4
diso_​to_​diso : 7
diso_​to_​phen : 2


Relationships:
none : 14
permuted_​term_​of : 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_CHEM75img Factor V C0015498
DISO_to_PHEN75img genetic aspects C0017399
DISO_to_DISO64img Complication Aspects C1171258
DISO_to_CHEM54img Factor V C0015498
DISO_to_PHEN50img genetic aspects C0017399
DISO_to_ANAT44img In Blood C0005768
DISO_to_DISO38img Venous Thrombosis C0042487
DISO_to_DISO37img Complication Aspects C1171258
DISO_to_ANAT29img In Blood C0005768
DISO_to_DISO29img Venous Thrombosis C0042487
DISO_to_DISO24img Thrombophilia C0398623
DISO_to_CHEM14img Prothrombin C0033706
DISO_to_DISO14img Thrombophilia C0398623
DISO_to_CHEM13img Protein C C0033621
DISO_to_DISOpermuted_term_ofimg Activated Protein C Resistance C0600433
Genes (7)

Species:
human : 7
SpeciesGeneGeneIdGene NameEvidence
HumanTFPI7035tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
img GENERIF, Score=660, Pubmed Id: 18067603, UMLKSK CUI: C0600433
HumanPROS15627protein S (alpha)
img GENERIF, Score=660, Pubmed Id: 18067603, UMLKSK CUI: C0600433
HumanPROC5624protein C (inactivator of coagulation factors Va and VIIIa)
img GENERIF, Score=901, Pubmed Id: 14976057, UMLKSK CUI: C0600433
HumanF52153coagulation factor V (proaccelerin, labile factor)
img GENERIF, Score=1000, Pubmed Id: 18449423, UMLKSK CUI: C0600433
img GENERIF, Score=1000, Pubmed Id: 18342013, UMLKSK CUI: C0600433
img GENERIF, Score=937, Pubmed Id: 17640947, UMLKSK CUI: C0600433
img GAD, Score=1000, Pubmed Id: 12434659, UMLKSK CUI: C0600433
img GENERIF, Score=937, Pubmed Id: 15961511, UMLKSK CUI: C0600433
img GENERIF, Score=694, Pubmed Id: 12091344, UMLKSK CUI: C0600433
img GENERIF, Score=1000, Pubmed Id: 12393556, UMLKSK CUI: C0600433
img GAD, Score=1000, Pubmed Id: 14711617, UMLKSK CUI: C0600433
HumanF22147coagulation factor II (thrombin)
img GENERIF, Score=1000, Pubmed Id: 16493484, UMLKSK CUI: C0600433
img GENERIF, Score=1000, Pubmed Id: 17890946, UMLKSK CUI: C0600433
HumanCPB21361carboxypeptidase B2 (plasma)
img GENERIF, Score=1000, Pubmed Id: 12165290, UMLKSK CUI: C0600433
HumanAPOH350apolipoprotein H (beta-2-glycoprotein I)
img GENERIF, Score=901, Pubmed Id: 19002041, UMLKSK CUI: C0600433
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0600433Activated Protein C Resistance0self