Mouse | PIM2 | 11040 | pim-2 oncogene | Pim-2 transgene induces lymphoid tumors, exhibiting potent synergy with c-myc. |
Mouse | YWHAB | 7529 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide | Two members of this family (cortactin and HS1) were differentially expressed in murine B lymphoid tumor cell lines; both were detected in plasmacytoma cell lines, however HS1 was additionally detected in pre-B lymphoma and B lymphoma cell lines. |
Mouse | RPA1 | 6117 | replication protein A1, 70kDa | Mice carrying a heterozygous missense change in one of the DNA-binding domains of Rpa1 develop lymphoid tumors, and their homozygous littermates succumb to early embryonic lethality. |
Mouse | ABCB4 | 5244 | ATP-binding cassette, sub-family B (MDR/TAP), member 4 | In independently derived drug-resistant sublines of the mouse lymphoid tumor P388, multidrug resistance is associated with the exclusive overexpression of the mdr3 gene. |
Mouse | HCLS1 | 3059 | hematopoietic cell-specific Lyn substrate 1 | Two members of this family (cortactin and HS1) were differentially expressed in murine B lymphoid tumor cell lines; both were detected in plasmacytoma cell lines, however HS1 was additionally detected in pre-B lymphoma and B lymphoma cell lines. |
Mouse | FLI1 | 2313 | Fli-1 proto-oncogene, ETS transcription factor | Other hematopoietic neoplasms induced by F-MuLV, including myeloid (granulocytic) and lymphoid tumors, did not show rearrangements of the Fli-1 locus. |
Mouse | CRKL | 1399 | v-crk avian sarcoma virus CT10 oncogene homolog-like | The coexpression of Crkl and Bcr/Abl in mice transgenic for P190 BCR/ABL and CRKL markedly increased the rapidity of development of leukemia/lymphoma, decreasing the average survival by 3.8 months. |
Mouse | BLK | 640 | B lymphoid tyrosine kinase | Expression of Blk(Y495F) in the B lineage at levels similar to that of endogenous Blk induced B lymphoid tumors of limited clonality, whose phenotypes are characteristic of B cell progenitors at the proB/preB-I to preB-II transition. |
Mouse | BCL3 | 602 | B-cell CLL/lymphoma 3 | Possible roles of p52 and Bcl-3 are discussed that may underlie the oncogenic potential of these proteins, as evidenced by recurrent chromosomal translocations of their genes in lymphoid tumors. |
Human | PBK | 55872 | PDZ binding kinase | Tissue distribution of TOPK mRNA expression was specific for the testis, T-LAK cells, activated lymphoid cells, and lymphoid tumors. |
Human | MCTS1 | 28985 | malignant T cell amplified sequence 1 | Our data suggest that high levels of MCT-1 protein may be associated with a high-risk subset of lymphoid neoplasms and may further support the potential role of MCT-1 in promoting human lymphoid tumor development. In human lymphoid tumors expression of MCT-1 is constant throughout the cell cycle and remains cytoplasmic. |
Human | HMHA1 | 23526 | histocompatibility (minor) HA-1 | Most of the leukemia/lymphoma cell lines have the same levels of HA-1 expression as a leukemia/lymphoma cell line, Raji. RESULTS: We found that mRNA of HA-1 is expressed in all leukemia/lymphoma cell lines and PBMNC. |
Human | CHEK2 | 11200 | checkpoint kinase 2 | To determine the potential role of CHK2 alterations in the pathogenesis of lymphoid neoplasms we have examined the gene status, protein, and mRNA expression in a series of tumors and nonneoplastic lymphoid samples. |
Human | GIPC1 | 10755 | GIPC PDZ domain containing family, member 1 | On the other hand, GIPC1 mRNA was almost undetectable in leukemia/lymphoma cell lines HL-60, Raji, and Daudi. |
Human | GPA33 | 10223 | glycoprotein A33 (transmembrane) | Other epithelial cancers, sarcomas, neuroectodermal tumors, and lymphoid neoplasms were generally A33 negative. |
Human | PTTG1 | 9232 | pituitary tumor-transforming 1 | To obtain additional data on the potential role of hpttg in lymphomagenesis we selected 150 cases of lymphoid tumors for the assessment of hpttg expression in tumor tissues. |
Human | EBAG9 | 9166 | estrogen receptor binding site associated, antigen, 9 | These findings indicate that expression of RCAS1 may be associated with the evasion from immune surveillance of cells infected with human T-lymphotropic virus type I, resulting in the development of overt leukemia/lymphoma. |
Human | RQCD1 | 9125 | RCD1 required for cell differentiation1 homolog (S. pombe) | These data suggested the presence of at least 3 tumor suppressor genes on 6q within RCD1, RCD2, and RCD3; they also showed associations between RCDs in 6q and subsets of NHL, including a specific association between a group of well-differentiated lymphoid neoplasms and RCD3. |
Human | BCL10 | 8915 | B-cell CLL/lymphoma 10 | Our data suggest that BCL10 mutations may play only a limited role in the pathogenesis of lymphoid neoplasms. CONCLUSION: The BCL10 mutations studied are rare events at the RNA level and may not be associated with the mechanism of tumorigenesis in most lymphoid tumors. |
Human | TCL1A | 8115 | T-cell leukemia/lymphoma 1A | We investigated the expression of the TCL1 protein in various types of B cell lymphomas according to the Revised European-American Classification of Lymphoid neoplasms. |
Human | CXCR4 | 7852 | chemokine (C-X-C motif) receptor 4 | The mini-HIV variant that uses CD4 and CXCR4 for cell entry could potentially be used against CXCR4-expressing malignancies such as T-lymphoblastic leukemia/lymphoma, natural killer leukemia, and some myeloid leukemias. |
Human | ZMYM2 | 7750 | zinc finger, MYM-type 2 | FGFR1 is fused with a novel zinc-finger gene, ZNF198, in the t(8;13) leukaemia/lymphoma syndrome. |
Human | XRCC5 | 7520 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | Expression of DNA repair gene Ku80 in lymphoid neoplasm. |
Human | VCAM1 | 7412 | vascular cell adhesion molecule 1 | Here, we studied VLA-4-dependent adhesion of the lymphoid tumor cell line Ramos to cells expressing wild type and mutant forms of VCAM-1. |
Human | TYK2 | 7297 | tyrosine kinase 2 | TYK2 is a key regulator of the surveillance of B lymphoid tumors. Our observations provide compelling evidence that TYK2 is an important regulator of lymphoid tumor surveillance. |