| Human | CMTM8 | 152189 | CKLF-like MARVEL transmembrane domain containing 8 | These results identify CKLFSF8 as a novel regulator of EGF-induced signaling and indicate that the association of EGFR with four transmembrane proteins is critical for EGFR desensitization |
| Human | P2RY12 | 64805 | purinergic receptor P2Y, G-protein coupled, 12 | Absence of desensitization of the Gi protein-coupled P2Y12 receptor-dependent responses could represent a mechanism to preserve the hemostatic properties in platelets both P2Y(1) and P2Y(12) desensitize in human platelets; P2Y(12), but not P2Y(1), desensitization is mediated by GRKs |
| Human | TRPM4 | 54795 | transient receptor potential cation channel, subfamily M, member 4 | hydrolysis of PI(4,5)P(2) underlies desensitization of TRPM4, and PI(4,5)P(2) is a general regulator for the gating of TRPM ion channels |
| Human | GHRL | 51738 | ghrelin/obestatin prepropeptide | The present findings show that the orexigenic action of exogenous ghrelin is not diminished by a chronic hyperghrelinemia and indicate that the food ingestive pathway of the GHS-R is not susceptible to desensitization |
| Human | CYSLTR1 | 10800 | cysteinyl leukotriene receptor 1 | Desensitization of the CysLT1R is the principal mechanism by which PKC regulates the functional consequences of its desensitization in tracheea smooth muscle |
| Human | CALCRL | 10203 | calcitonin receptor-like | Endogenous endothelial CRLR: subcellular localization, internalization and desensitization upon interaction with adrenomedullin and CGRP |
| Human | TNK2 | 10188 | tyrosine kinase, non-receptor, 2 | These data suggest that Ack1 is involved in an early step of EGFR desensitization |
| Human | GLP2R | 9340 | glucagon-like peptide 2 receptor | GLP-2 receptor C terminus has a role in modulating beta-arrestin-2 association but not ligand-induced desensitization, endocytosis, and G-protein-dependent effector activation |
| Human | PDE5A | 8654 | phosphodiesterase 5A, cGMP-specific | Phosphorylation of PDE5 seems to act as memory switch for activation leading to long-term desensitization of the signaling pathway |
| Human | CXCR4 | 7852 | chemokine (C-X-C motif) receptor 4 | CCR5-binding chemokines modulate CXCL12 (SDF-1)-induced responses of progenitor B cells in human bone marrow through heterologous desensitization of the chemokine receptor |
| Human | TRPV1 | 7442 | transient receptor potential cation channel, subfamily V, member 1 | calmodulin binds to a 35-aa segment in the C terminus of TRPV1, and disruption of the calmodulin-binding segment prevents TRPV1 desensitization Proposal that residue Y671 is critical for the high relative Ca(2+) permeability of TRPV1 and participates in the structural rearrangements of the channel protein leading to Ca(2+)-dependent desensitization Ser-116 and possibly Thr-370 of vanilloid receptor TRPV1 are the most important residues involved in the mechanism of PKA-dependent reduction of desensitization of capsaicin-activated currents Ser-116 and possibly Thr-370 are the most important residues involved in the cyclic AMP-dependent protein kinase pathway reduction of desensitization of capsaicin-activated currents |
| Human | TYMS | 7298 | thymidylate synthetase | Overexpression of thymidylate synthase mediates desensitization for 5-fluorouracil of cervical cancer cells |
| Human | TSHR | 7253 | thyroid stimulating hormone receptor | results indicate that the TSH receptor internalization might in part be responsible for TSH receptor desensitization on TSH binding |
| Human | TNNC1 | 7134 | troponin C type 1 (slow) | the desensitization of myofilaments from G159D-CTnC is expected to weaken the contractile force of the myocardium, whereas the lack of myofilament changes from L29Q-CTnC may preserve diastolic and systolic function |
| Human | TBXA2R | 6915 | thromboxane A2 receptor | TBXA2R alpha undergoes both NO- and prostacyclin-mediated desensitization that occur through independent mechanisms involving direct PKG phosphorylation of Ser331, in response to NO, and PKA phosphorylation of Ser329, in response to prostacyclin |
| Human | SSTR2 | 6752 | somatostatin receptor 2 | Somatostatin caused rapid sst(2a) receptor phosphorylation and desensitization of epithelial antisecretory responses |
| Human | SRC | 6714 | v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog | src has a role in promoting destruction of c-Cbl and enabling EGFR to evade desensitization as part of an oncogenesis pathway |
| Human | CXCL12 | 6387 | chemokine (C-X-C motif) ligand 12 | CCR5-binding chemokines modulate induced responses of progenitor B cells in human bone marrow through heterologous desensitization of the CXCR4 chemokine receptor |
| Human | GRK1 | 6011 | G protein-coupled receptor kinase 1 | G protein-coupled receptor kinase site serine cluster has a role in beta2-adrenergic receptor internalization, desensitization, and beta-arrestin translocation |
| Human | PRKCA | 5578 | protein kinase C, alpha | Inhibition of the oxidative burst, i.e., cellular desensitization, was clearly reversed in cells overexpressing PKC alpha, pointing to PKC alpha as the major transmitter in eliciting the oxidative burst in monocytes/macrophages |
| Human | PPARG | 5468 | peroxisome proliferator-activated receptor gamma | Activation of PPAR gamma by oxidized lipoproteins (oxLDL) promotes macrophage desensitization by reducing oxLDL-stimulated oxygen radical formation, an important determinant of the activation/deactivation balance in macrophages |
| Human | PLAUR | 5329 | plasminogen activator, urokinase receptor | G-CSF-induced upregulation of uPAR on circulating CD33+ and CD14+ cells, increased uPAR shedding & serum c-suPAR, which could contribute to the mobilization of HSCs by promoting their FPR-mediated migration and by inducing CXCR4 desensitization |
| Human | PDGFRB | 5159 | platelet-derived growth factor receptor, beta polypeptide | GPRK2-mediated PDGFRbeta seryl phosphorylation plays an important role in desensitizing PDGFRbeta; this desensitization involves GPRK2-mediated phosphorylation of PDGFRbeta Ser(1104), with consequent dissociation of the PDGFRbeta from NHERF |
| Human | P2RY2 | 5029 | purinergic receptor P2Y, G-protein coupled, 2 | Our results indicate a role for receptor phosphorylation by phorbol-insensitive protein kinases in agonist-induced desensitization of the P2Y2 nucleotide receptor P2UR desensitization on single endothelial cells is reported |
| Human | P2RY1 | 5028 | purinergic receptor P2Y, G-protein coupled, 1 | both P2Y(1) and P2Y(12) desensitize in human platelets; P2Y(12), but not P2Y(1), desensitization is mediated by GRKs Agonist-induced P2Y1 receptor desensitization was accompanied by its internalization in platelets and transfected cells |
