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Details
Link-It Detail - Disease - Esophageal Dysplasia
Debug Stats
  • ### Total Build Time: 28 ms 24.054 KB
  • CONCEPT_NAME gt=12 ms Completed: 12 ms rowSize= 338 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 613 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 14 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=0 Completed: 0 ms rowSize= 7 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 15 bytes
  • CONCEPT_RELATIONSHIPS gt=6 ms Completed: 6 ms rowSize= 10.478 KB
  • CONCEPT_GENES gt=9 ms Completed: 9 ms rowSize= 11.423 KB
  • CONCEPT_XREFS gt=1 ms Completed: 1 ms rowSize= 1.154 KB
  • CONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Esophageal Dysplasia C0586354
Definition (1)
A lesion that is characterized by architectural and cytologic abnormalities of the esophageal epithelium, and carries a predisposition for progression to invasive carcinoma. Intraepithelial neoplasia (dysplasia) of the esophagus is graded as low or high grade. In this two-tier system, severe dysplasia and carcinoma in situ are included under the rubric of high grade intraepithelial neoplasia and may have the same clinical implications. (WHO, 2000) -- 2003
Relationships (20)

Relation Types:
diso_​to_​anat : 9
diso_​to_​diso : 11


Relationships:
is_​abnormal_​cell_​of_​disease : 3
is_​associated_​anatomic_​site_​of : 1
is_​finding_​of_​disease : 2
is_​normal_​cell_​origin_​of_​disease : 1
is_​normal_​tissue_​origin_​of_​disease : 2
is_​not_​abnormal_​cell_​of_​disease : 1
is_​not_​finding_​of_​disease : 1
is_​primary_​anatomic_​site_​of_​disease : 1
isa : 6
may_​be_​molecular_​abnormality_​of_​disease : 2
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_ANATis_associated_anatomic_site_ofimg Digestive System C0012240
DISO_to_ANATis_abnormal_cell_of_diseaseimg Dysplastic Epithelial Cell C1512100
DISO_to_ANATis_normal_cell_origin_of_diseaseimg Epithelial Cells C0014597
DISO_to_ANATis_normal_tissue_origin_of_diseaseimg Epithelial Tissue C0014609
DISO_to_ANATis_normal_tissue_origin_of_diseaseimg Esophageal mucous membrane C0227176
DISO_to_ANATis_primary_anatomic_site_of_diseaseimg Esophagus C0014876
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Cell C0597032
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Epithelial Cell C1513959
DISO_to_ANATis_not_abnormal_cell_of_diseaseimg Neoplastic Smooth Muscle Cell C1514098
DISO_to_DISOis_finding_of_diseaseimg 74 DYSPLASIAS C0334044
DISO_to_DISOisaimg Carcinoma in situ of esophagus C0154059
DISO_to_DISOis_finding_of_diseaseimg Epithelial Component Present C1707933
DISO_to_DISOisaimg Esophageal Glandular Dysplasia C1333447
DISO_to_DISOisaimg Esophageal High Grade Intraepithelial Neoplasia C1333450
DISO_to_DISOisaimg Esophageal Low Grade Dysplasia C0586355
DISO_to_DISOisaimg Esophageal Squamous Dysplasia C1333468
DISO_to_DISOmay_be_molecular_abnormality_of_diseaseimg FHIT Gene Inactivation C1517095
DISO_to_DISOmay_be_molecular_abnormality_of_diseaseimg Inactivation of p53 Tumor-Suppressor Gene C1515171
DISO_to_DISOis_not_finding_of_diseaseimg Invasive Lesion C1334278
DISO_to_DISOisaimg Moderate Esophageal Dysplasia C0586356
Genes (10)

Species:
human : 10
SpeciesGeneGeneIdGene NameEvidence
HumanPGA3643834pepsinogen 3, group I (pepsinogen A)
img GENERIF, Score=913, Pubmed Id: 18844222, UMLKSK CUI: C0586354
HumanVDR7421vitamin D (1,25- dihydroxyvitamin D3) receptor
img GENERIF, Score=1000, Pubmed Id: 18662591, UMLKSK CUI: C0586354
HumanTP537157tumor protein p53
img GENERIF, Score=1000, Pubmed Id: 17060721, UMLKSK CUI: C0586354
HumanSERPINB36317serpin peptidase inhibitor, clade B (ovalbumin), member 3
img GENERIF, Score=1000, Pubmed Id: 17523076, UMLKSK CUI: C0586354
HumanPGC5225progastricsin (pepsinogen C)
img GENERIF, Score=913, Pubmed Id: 18844222, UMLKSK CUI: C0586354
HumanMTHFR4524methylenetetrahydrofolate reductase (NAD(P)H)
img GENERIF, Score=1000, Pubmed Id: 18662591, UMLKSK CUI: C0586354
HumanMPO4353myeloperoxidase
img GENERIF, Score=1000, Pubmed Id: 18662591, UMLKSK CUI: C0586354
HumanCDKN2A1029cyclin-dependent kinase inhibitor 2A
img GENERIF, Score=1000, Pubmed Id: 17060721, UMLKSK CUI: C0586354
HumanCCND1595cyclin D1
img GENERIF, Score=1000, Pubmed Id: 17060721, UMLKSK CUI: C0586354
HumanALDH2217aldehyde dehydrogenase 2 family (mitochondrial)
img GAD, Score=882, Pubmed Id: 10896918, UMLKSK CUI: C0586354
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0586354Esophageal Dysplasia0self