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Genes (14)
Species: human : 14 | |
Human | ANKH | 56172 | ANKH inorganic pyrophosphate transport regulator | ANKH may be a candidate gene affecting bone size and geometry variation, and thus may be relevant for osteoporosis fracture risk | Human | VDR | 7421 | vitamin D (1,25- dihydroxyvitamin D3) receptor | interaction between ERalpha and vitamin D receptor gene polymorphisms leads to increased risk of osteoporotic vertebral fractures in women, largely independent of bone mineral density | Human | TIMP2 | 7077 | TIMP metallopeptidase inhibitor 2 | Identification of two previously unreported SNPs in FGFR1 and FABP3 associated with BMD and a third SNP in TIMP2 related to risk for non-vertebral osteoporotic fractures | Human | SP1 | 6667 | Sp1 transcription factor | Our study may provide evidence that the Sp1 polymorphism may ameliorate the effects of HRT on bone mineral density suggesting some additional regimens may be used to support bone strength and to decrease osteoporotic fractures | Human | SHBG | 6462 | sex hormone-binding globulin | significant association with BMD or osteoporotic fractures has not been demonstrated | Human | TNFRSF11B | 4982 | tumor necrosis factor receptor superfamily, member 11b | Polymorphisms in the osteoprotegerin gene are associated with osteoporotic fractures Title:Polymorphisms in the osteoprotegerin gene are associated with osteoporotic fractures.|Association:Y|Conclusion:In conclusion, we have examined the human OPG gene for polymorphisms and found 12. The rare alleles of the A163-G and T245-G were significantly more common among patients with vertebral fractures. Two gene variants of key biological proteins increase the risk of osteoporosis and osteoporotic fracture | Human | MTHFR | 4524 | methylenetetrahydrofolate reductase (NAD(P)H) | study concludes that the C677T polymorphism of the MTHFR gene does not appear to be associated with the overall risk of osteoporotic fractures | Human | LRP5 | 4041 | low density lipoprotein receptor-related protein 5 | genetic variation in LRP5 seems to be of importance for regulation of bone mass and osteoporotic fractures | Human | ESR1 | 2099 | estrogen receptor 1 | Title:A TA repeat polymorphism in the estrogen receptor gene is associated with osteoporotic fractures but polymorphisms in the first exon and intron are not.|Association:Y|Conclusion:A TA repeat polymorphism in the ER gene is associated with increased risk of osteoporotic fractures and a modest reduction in bone mass. Polymorphisms in the first exon and first intron of the ER gene are not associated with osteoporotic fractures, bone mass, or bone turnover. interaction between estrogen receptor 1 alpha and vitamin D receptor gene polymorphisms leads to increased risk of osteoporotic vertebral fractures in women, largely independent of bone mineral density | Human | CYP19A1 | 1588 | cytochrome P450, family 19, subfamily A, polypeptide 1 | A common haplotype of aromatase associated with gene expression is also associated with the risk of osteoporotic vertebral fractures in postmenopausal women | Human | COL1A1 | 1277 | collagen, type I, alpha 1 | Association of polymorphisms and haplotypes in the 5' region of COLIA1 gene with the risk of osteoporotic fractures in Russian women from Volga-Ural region in men, the "ss" genotype of COLIA1 polymorphism could be the best osteoporotic fracture risk genetic predictor, independent of bone mass values The Sp1 transcription factor binding site polymorphism of COL1A1 is associated with a modest reduction in bone mineral density and a significant increase in risk of osteoporotic fracture, particularly vertebral fracture the presence of at least one copy of the T allele is associated with osteoporotic fractures, but not with low bone mineral density, in women from the Canary Islands | Human | BMP2 | 650 | bone morphogenetic protein 2 | a region on the short arm of Chromosome 20 contains a gene or genes that appear to be a major risk factor for osteoporosis and osteoporotic fractures, including BMP2 | Human | AR | 367 | androgen receptor | The CAG repeat polymorphism in the first exon of the androgen receptor (AR) gene is associated with reduced bone mass and increased risk of osteoporotic fractures in women | Human | APOE | 348 | apolipoprotein E | Our data do not support the hypothesis that the ApoE*4 risk allele is associated with BMD, increased bone loss, or an increased risk of osteoporotic fractures |
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