Human | DAB2IP | 153090 | DAB2 interacting protein | Normal prostatic epithelial cells have elevated DAB2IP mRNA compared with cancer cells, which correlates with increased DAB2IP promoter activity |
Human | TPH2 | 121278 | tryptophan hydroxylase 2 | TT genotype of tph2 carriers compensate deficits in executive control functions by increased brain activity |
Human | LRRK2 | 120892 | leucine-rich repeat kinase 2 | The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity |
Human | ADC | 113451 | arginine decarboxylase | This study also suggests that highly expressed AZI may be partly responsible for increased ODC activity and cellular transformation |
Human | HDAC10 | 83933 | histone deacetylase 10 | Results suggest that the "T" allele of HDAC10-589C>T affect on the increased transcription activity, and might accelerate HCC development through increased expression of HDAC10 |
Human | DHDDS | 79947 | dehydrodolichyl diphosphate synthase | identification and characterization; overexpression of CIT in CHO cells results in a modest increase in cis-isoprenyltransferase activity associated with microsomal fractions |
Human | IL21 | 59067 | interleukin 21 | IL-21 may play an important role in enhancing the host immune response of Sezary syndrome patients through the increased cytolytic activity of T and NK cells |
Human | HAMP | 57817 | hepcidin antimicrobial peptide | Hepatitis C virus-induced oxidative stress suppresses hepcidin expression through increased histone deaceetylase activity |
Human | AKR1B10 | 57016 | aldo-keto reductase family 1, member B10 (aldose reductase) | Data show tha activation of protein kinase C and tyrosine kinase by 12-O-tetradecanoylphorbol-13-acetate elicits increased promoter activity of aldose reductase gene via nuclear factor kappaB |
Human | DIABLO | 56616 | diablo, IAP-binding mitochondrial protein | Expression of full-length Par-4 in human-bone mesenchymal cells resulted in increased activity of the Smac promoter |
Human | ADCY10 | 55811 | adenylate cyclase 10 (soluble) | Increased sodium-potassium pump activity |
Human | ACOT11 | 26027 | acyl-CoA thioesterase 11 | BFIT supports the transition of thermogenic brown adipose tissue towards increased metabolic activity, probably through alteration of intracellular fatty acyl-CoA concentration |
Human | CADM1 | 23705 | cell adhesion molecule 1 | A549 lung cancer cells expressing wild-type TSLC1 showed suppression of anchorage-independent colony formation in soft agar and markedly increased cell-cell adhesion activity |
Human | SGK3 | 23678 | serum/glucocorticoid regulated kinase family, member 3 | In conclusion, the kinases SGK1 and SGK3 increase EAAT5 activity by increasing cell surface abundance of the carrier |
Human | SIRT1 | 23411 | sirtuin 1 | SIRT1 genetic variants may represent a relevant determinant for the response rate of individuals undergoing caloric restriction and increased physical activity |
Human | MAN1B1 | 11253 | mannosidase, alpha, class 1B, member 1 | Increased activity of alpha-mannosidase in the peritoneal fluid is associated with gynecologic cancers and pelvic inflammatory disease |
Human | GFPT2 | 9945 | glutamine-fructose-6-phosphate transaminase 2 | Increased GFAT activity appears to be associated with insulin resistance, postprandial hyperglycaemia and oxidative stress in T2DM and may point towards a potential pathway amenable for therapeutic intervention |
Human | CYP7B1 | 9420 | cytochrome P450, family 7, subfamily B, polypeptide 1 | Increased CYP7B activity leads to higher levels of 7alpha-OH-DHEA in synovial fluid which may contribute to the maintenance of chronic inflammation observed in rheumatoid arthritis patients |
Human | MBD2 | 8932 | methyl-CpG binding domain protein 2 | We found clinically relevant levels of Hcy (0-500 microM) induced elevation of SAH, declination of SAM and SAM/SAH ratio and reduced expression of SAHH and MBD2, but increased activity of DNMT3a and DNMT3b affecting DNA methylation |
Human | TNFSF10 | 8743 | tumor necrosis factor (ligand) superfamily, member 10 | The DR4-selective Apo2L/TRAIL variants examined in this study showed a markedly reduced ability to trigger apoptosis, whereas the DR5-selective variants had minimally decreased or slightly increased apoptosis-inducing activity TRAIL expression was mediated by increased transcriptional activity of the TRAIL promoter, suggesting lineage-specific regulation of TRAIL during megakaryocyte differentiation Nocodazole treatment inhibited TRAIL-increased NOS activity, indicating that, on cultured HUVEC, TRAIL ability to affect NO production by regulating eNOS sub-cellular distribution is mediated by cytoskeleton and Golgi complex modifications |
Human | ANP32A | 8125 | acidic (leucine-rich) nuclear phosphoprotein 32 family, member A | tyrosine phosphorylation of PHAPI is accompanied by the release of PP2A from association with PHAPI, allowing increased phosphatase activity of PP2A and consequent complete dephosphorylation of the ERK kinase, MEK1/2, by 10 min and of ERK1/2 by 60 min |
Human | PLA2G7 | 7941 | phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) | An independent association of increased plasma Lp-PLA(2) activity with coronary heart disease and myocardial infarction existed in this Chinese Han Population |
Human | XRCC2 | 7516 | X-ray repair complementing defective repair in Chinese hamster cells 2 | Considering that the XRCC2 (R188H) allele reduces risk to epithelial ovarian cancer, the increased XRCC2 activity with the R188H polymorphism may have clinical benefit in preventing cancer risk |
Human | WRN | 7486 | Werner syndrome, RecQ helicase-like | altered DNA double-strand break repair in CML cells is caused by the increased activity of an alternative nonhomologous end-joining repair pathway, involving DNA ligase IIIalpha and WRN |
Human | WNT1 | 7471 | wingless-type MMTV integration site family, member 1 | CTNNB strongly increased activity of the eN/Nt5 promoter and this increase depended on the presence of TCF-1; demonstrated a link between Wnt signaling and the regulation of eN and ADA, which control the metabolism of adenosine |