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Details
Link-It Detail - Disease - Paraneoplastic Cerebellar Degeneration
Debug Stats
  • ### Total Build Time: 19 ms 21.562 KB
  • CONCEPT_NAME gt=3 ms Completed: 3 ms rowSize= 437 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 663 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=7 ms Completed: 7 ms rowSize= 188 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=3 ms Completed: 3 ms rowSize= 1,013 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 6.689 KB
  • CONCEPT_RELATIONSHIPS gt=4 ms Completed: 4 ms rowSize= 8.234 KB
  • CONCEPT_GENES gt=1 ms Completed: 1 ms rowSize= 3.185 KB
  • CONCEPT_XREFS gt=1 ms Completed: 1 ms rowSize= 1.172 KB
  • CONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes
  • Reload Stats
Disease (2)
Paraneoplastic Cerebellar Degeneration C0393534
CEREBELLAR DEGENERATION PARANEOPL
Definition (1)
Cerebellar degeneration associated with a remote neoplasm. Clinical manifestations include progressive limb and GAIT ATAXIA; DYSARTHRIA; and NYSTAGMUS, PATHOLOGIC. The histologic type of the associated neoplasm is usually carcinoma or lymphoma. Pathologically the cerebellar cortex and subcortical nuclei demonstrate diffuse degenerative changes. Anti-Purkinje cell antibodies (anti-Yo) are found in the serum of approximately 50% of affected individuals. (Adams et al., Principles of Neurology, 6th ed, p686)
Semantic Types (1)
Disease or Syndrome (T047)
Parents (2)
img Cerebellar Diseases C0007760
img Paraneoplastic Syndromes, Nervous System C0751911
Ancestral Roots
RootRoot Plus OneDepthParent
img Nervous System Diseases C0027765img Central Nervous System Diseases C00076825img Cerebellar Diseases C0007760
img Nervous System Diseases C0027765img Neurodegenerative Diseases C05248514img Paraneoplastic Syndromes, Nervous System C0751911
img Neoplasms C0027651img Neoplasms by Site C00276535img Paraneoplastic Syndromes, Nervous System C0751911
img Nervous System Diseases C0027765img Nervous System Neoplasms C00277664img Paraneoplastic Syndromes, Nervous System C0751911
img Neoplasms C0027651img Paraneoplastic Syndromes C00304724img Paraneoplastic Syndromes, Nervous System C0751911
Relationships (17)

Relation Types:
diso_​to_​anat : 2
diso_​to_​chem : 5
diso_​to_​diso : 8
diso_​to_​gene : 2


Relationships:
none : 11
gene_​associated_​with_​disease : 2
gene_​product_​malfunction_​associated_​with_​disease : 1
is_​associated_​anatomic_​site_​of : 2
permuted_​term_​of : 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_CHEM15img Abs - Autoantibodies C0004358
DISO_to_CHEM14img Nerve Tissue Proteins C0027759
DISO_to_CHEM13img Abs - Autoantibodies C0004358
DISO_to_DISO13img Ovarian Neoplasms C0919267
DISO_to_CHEM10img Nerve Tissue Proteins C0027759
DISO_to_DISO10img Adenocarcinoma C0001418
DISO_to_DISO8img Adenocarcinoma C0001418
DISO_to_DISO8img Breast Neoplasms C1458155
DISO_to_DISO8img Complication Aspects C1171258
DISO_to_DISO8img Lung Neoplasms C0024121
DISO_to_DISO8img Ovarian Neoplasms C0919267
DISO_to_ANATis_associated_anatomic_site_ofimg Central Nervous System C0927232
DISO_to_ANATis_associated_anatomic_site_ofimg Nervous System C0027763
DISO_to_CHEMgene_product_malfunction_associated_with_diseaseimg CDR1 protein, human C1437277
DISO_to_DISOpermuted_term_ofimg CEREBELLAR DEGENERATION PARANEOPL C0393534
DISO_to_GENEgene_associated_with_diseaseimg CDR1 gene C1332741
DISO_to_GENEgene_associated_with_diseaseimg CDR1 wt Allele C1706547
Genes (1)

Species:
human : 1
SpeciesGeneGeneIdGene NameEvidence
HumanCDR21039cerebellar degeneration-related protein 2, 62kDa
img GENERIF, Score=1000, Pubmed Id: 18025478, UMLKSK CUI: C0393534
img GENERIF, Score=1000, Pubmed Id: 9809559, UMLKSK CUI: C0393534
img GENERIF, Score=1000, Pubmed Id: 15081253, UMLKSK CUI: C0393534
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0393534Paraneoplastic Cerebellar Degeneration0self