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Details
Link-It Detail - Disease - Malignant neoplasm of prostate
Debug Stats
  • ### Total Build Time: 110 ms 47.165 KB
  • CONCEPT_NAME gt=2 ms Completed: 2 ms rowSize= 358 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 1.166 KB
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=0 Completed: 0 ms rowSize= 7 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 15 bytes
  • CONCEPT_RELATIONSHIPS gt=15 ms Completed: 15 ms rowSize= 14.506 KB
  • CONCEPT_GENES gt=91 ms Completed: 91 ms rowSize= 29.909 KB
  • CONCEPT_XREFS gt=1 ms Completed: 1 ms rowSize= 1.164 KB
  • CONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Malignant neoplasm of prostate C0376358
Definition (1)

The prostate is the gland below a man's bladder that produces fluid for semen. Prostate cancer is the second most common cause of death from cancer in men of all ages. It is rare in men younger than 40.

Levels of a substance called prostate specific antigen (PSA) is often high in men with prostate cancer. However, PSA can also be high with other prostate conditions. Since the PSA test became common, most prostate cancers are found before they cause symptoms. Symptoms of prostate cancer may include

  • Problems passing urine, such as pain, difficulty starting or stopping the stream, or dribbling
  • Low back pain
  • Pain with ejaculation

Prostate cancer treatment often depends on the stage of the cancer. How fast the cancer grows and how different it is from surrounding tissue helps determine the stage. Treatment may include surgery, radiation therapy, chemotherapy or control of hormones that affect the cancer.

Relationships (33)

Relation Types:
diso_​to_​anat : 5
diso_​to_​chem : 1
diso_​to_​diso : 25
diso_​to_​gene : 2


Relationships:
associated_​with : 1
classified_​as : 2
gene_​associated_​with_​disease : 2
gene_​product_​malfunction_​associated_​with_​disease : 1
is_​abnormal_​cell_​of_​disease : 2
is_​associated_​anatomic_​site_​of : 2
isa : 8
location_​of : 1
mapped_​to : 12
related_​to : 1
used_​for : 1
Page Size
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Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_ANATis_abnormal_cell_of_diseaseimg Cancer Cell C0334227
DISO_to_ANATis_associated_anatomic_site_ofimg Male Reproductive System C1963704
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Cell C0597032
DISO_to_ANATlocation_ofimg Prostate C0033572
DISO_to_ANATis_associated_anatomic_site_ofimg Reproductive system C1261210
DISO_to_CHEMgene_product_malfunction_associated_with_diseaseimg Cathepsin H C0054869
DISO_to_DISOmapped_toimg Adenocarcinoma of Prostate C0007112
DISO_to_DISOclassified_asimg Carcinoma in situ of prostate C0154088
DISO_to_DISOmapped_toimg Ductal Adenocarcinoma of Prostate C0349672
DISO_to_DISOclassified_asimg Encounter due to personal history of malignant neoplasm of prostate C0260429
DISO_to_DISOisaimg Extramedullary Myeloid Neoplasm of Prostate C1335514
DISO_to_DISOmapped_toimg Extraprostatic extension of tumor present, non-focal C1720586
DISO_to_DISOmapped_toimg HRPC C1328504
DISO_to_DISOmapped_toimg Local recurrence of malignant tumor of prostate C1282482
DISO_to_DISOisaimg Lymphoma of Prostate C1335512
DISO_to_DISOassociated_withimg Malignant Neoplasms C0006826
DISO_to_DISOisaimg Malignant Phyllodes Tumor of Prostate C1334615
DISO_to_DISOmapped_toimg Malignant neoplasm of prostate C0376358
DISO_to_DISOisaimg Malignant tumor involving prostate by direct extension from bladder C1297952
DISO_to_DISOisaimg Metastases to Prostate C0347001
DISO_to_DISOmapped_toimg Oat Cell Carcinoma of Prostate C1300585
DISO_to_DISOisaimg PROSTATE, SARCOMA C0238393
DISO_to_DISOisaimg Primary malignant neoplasm of prostate C1330959
DISO_to_DISOisaimg Prostate Squamous Cell Carcinoma C1302530
DISO_to_DISOmapped_toimg Prostate carcinoma C0600139
Genes (731)

Species:
human : 731
Page Size
Current 25
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Current 1
SpeciesGeneGeneIdGene NameEvidence
HumanHPC6100188789Prostate cancer, susceptibility to
img OMIM, Score=833, UMLKSK CUI: C0376358
HumanCCR2729230chemokine (C-C motif) receptor 2
img GENERIF, Score=734, Pubmed Id: 17216598, UMLKSK CUI: C0376358
HumanHPC5619402prostate cancer, hereditary, 5
img OMIM, Score=833, UMLKSK CUI: C0376358
HumanKLKP1606293kallikrein pseudogene 1
img GENERIF, Score=1000, Pubmed Id: 18196551, UMLKSK CUI: C0376358
HumanPCOTH542767
img GENERIF, Score=734, Pubmed Id: 15930275, UMLKSK CUI: C0376358
HumanTBC1D3B414059TBC1 domain family, member 3B
img GENERIF, Score=1000, Pubmed Id: 12359748, UMLKSK CUI: C0376358
HumanHPC4408260Prostate cancer, hereditary, 4
img OMIM, Score=833, UMLKSK CUI: C0376358
HumanTDF403078
img GENERIF, Score=734, Pubmed Id: 14745005, UMLKSK CUI: C0376358
HumanC5orf39389289
img GENERIF, Score=1000, Pubmed Id: 18636554, UMLKSK CUI: C0376358
HumanPRSS41360226protease, serine, 41
img GENERIF, Score=1000, Pubmed Id: 18844450, UMLKSK CUI: C0376358
HumanHPCQTL19347747Prostate cancer aggressiveness quantitative trait locus on chromosome 19
img OMIM, Score=833, UMLKSK CUI: C0376358
HumanLOC285634285634
img GENERIF, Score=734, Pubmed Id: 16007164, UMLKSK CUI: C0376358
HumanKCNRG283518potassium channel regulator
img GENERIF, Score=673, Pubmed Id: 12650944, UMLKSK CUI: C0376358
HumanSTEAP2261729STEAP family member 2, metalloreductase
img GENERIF, Score=694, Pubmed Id: 15897894, UMLKSK CUI: C0376358
HumanPI16221476peptidase inhibitor 16
img GENERIF, Score=1000, Pubmed Id: 17062675, UMLKSK CUI: C0376358
HumanALKBH3221120alkB, alkylation repair homolog 3 (E. coli)
img GENERIF, Score=1000, Pubmed Id: 17968469, UMLKSK CUI: C0376358
HumanCRTC2200186CREB regulated transcription coactivator 2
img GENERIF, Score=694, Pubmed Id: 18831768, UMLKSK CUI: C0376358
img GENERIF, Score=734, Pubmed Id: 18776922, UMLKSK CUI: C0376358
HumanCADM4199731cell adhesion molecule 4
img GENERIF, Score=1000, Pubmed Id: 16261159, UMLKSK CUI: C0376358
HumanNEWENTRY192343Record to support submission of GeneRIFs for a gene not in Gene (human; man).
img GENERIF, Score=694, Pubmed Id: 18027867, UMLKSK CUI: C0376358
HumanADAMTS15170689ADAM metallopeptidase with thrombospondin type 1 motif, 15
img GENERIF, Score=1000, Pubmed Id: 15599946, UMLKSK CUI: C0376358
HumanOXER1165140oxoeicosanoid (OXE) receptor 1
img GENERIF, Score=694, Pubmed Id: 16289380, UMLKSK CUI: C0376358
HumanTMPRSS6164656transmembrane protease, serine 6
img GENERIF, Score=734, Pubmed Id: 18449907, UMLKSK CUI: C0376358
HumanDAB2IP153090DAB2 interacting protein
Click here to display 3 evidence detail records.
HumanCREB3L4148327cAMP responsive element binding protein 3-like 4
img GENERIF, Score=673, Pubmed Id: 11830526, UMLKSK CUI: C0376358
HumanNRG4145957neuregulin 4
img GENERIF, Score=861, Pubmed Id: 17545517, UMLKSK CUI: C0376358
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0376358Malignant neoplasm of prostate0self