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Genes (20)
Species: human : 20 | |
Human | PGA3 | 643834 | pepsinogen 3, group I (pepsinogen A) | Higher levels of Pepsinogen I is associated with early gastric cancer | Human | TPBG | 7162 | trophoblast glycoprotein | RESULTS: The 5T4 antigen was detected in 41% of primary gastric tumours including early gastric cancer. | Human | TP53 | 7157 | tumor protein p53 | The Pro/Pro genotype of the p53 codon 72 polymorphism carries a higher risk for gastric cancer in general and is also associated with a much higher risk for early gastric cancer than advanced gastric cancer | Human | TIMP2 | 7077 | TIMP metallopeptidase inhibitor 2 | In order to investigate the correlation between expressions of TIMP-2, MMPs and clinical outcome, immunohistochemical staining of MMP-2, MMP-9, and TIMP-2 were performed on paraffin-embedded tissue sections of 15 early gastric cancers (EGC) and 15 advanced gastric carcinomas (AGC) without nodal metastasis and 15 AGC with nodal metastasis (AGCn+). Early gastric cancer revealed diffuse and strong TIMP-2 expressions. | Human | TFF1 | 7031 | trefoil factor 1 | TFF1 showed a statistically significant difference between early-onset gastric cancers and conventional gastric cancers | Human | SRY | 6736 | sex determining region Y | For this purpose we derived pluripotent EGC lines from sex-reversed embryos, either XY embryos deleted for Sry (XY(Tdym1)) or XX embryos carrying an Sry transgene. | Human | SDC1 | 6382 | syndecan 1 | Reduction of syndecan-1 expression in differentiated type early gastric cancer and background mucosa with gastric cellular phenotype. Syndecan-1 and E-cadherin expression in differentiated type of early gastric cancer. | Human | REG1A | 5967 | regenerating islet-derived 1 alpha | REG Ialpha gene is inducible by cytokine stimulation and its gene product may function as a mitogenic and/or an antiapoptotic factor in the development of early gastric cancer | Human | PTPN11 | 5781 | protein tyrosine phosphatase, non-receptor type 11 | Tyrosine-phosphorylated CagA and CagA-coimmunoprecipitated SHP-2 were detected in gastric mucosa from H. pylori-positive patients with atrophic gastritis and in noncancerous tissues from H. pylori-positive patients with early gastric cancer. | Human | PTGS2 | 5743 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | COX-2 showed a statistically significant difference between early-onset gastric cancers and conventional gastric cancers | Human | SRGN | 5552 | serglycin | METHODS: In study 1, postprandial symptoms and gastric emptying were compared between 2 groups of 12 patients with early gastric cancer more than 1 year after either PPG (PPG group) or distal gastrectomy (DG) (DG group). | Human | PGC | 5225 | progastricsin (pepsinogen C) | Higher levels of Pepsinogen II is associated with early gastric cancer | Human | NME1 | 4830 | NME/NM23 nucleoside diphosphate kinase 1 | These results suggest that there would be correlation between the expression of c-erB-2 and depth of invasion and lymph node metastasis, and the nm23 may suppress metastatic potential in early gastric cancer. [Immunohistochemical analysis of c-erB-2 and nm23 expression in early gastric carcinoma] The expression of c-erB-2 and nm23 genes product were investigated immunohistochemically in 108 resected cases of early gastric cancer. The expression of c-erB-2 and nm23 genes product were investigated immunohistochemically in 108 resected cases of early gastric cancer. These results suggest that there would be correlation between the expression of c-erB-2 and depth of invasion and lymph node metastasis, and the nm23 may suppress metastatic potential in early gastric cancer. | Human | JUP | 3728 | junction plakoglobin | The purpose of this study was to evaluate the expression of E-cadherin and alpha-, beta-, and gamma-catenin in a larger sample of early gastric cancer, and to examine the relation between these expressions and various clinicopathologic variables. The expression of E-cadherin and alpha-, beta-, and gamma-catenin was investigated using immunohistochemical technique with formalin-fixed, paraffin-embedded tissue specimens obtained from 108 patients who underwent surgery for early gastric cancer. | Human | GALNT3 | 2591 | UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3) | CONCLUSIONS: GalNAc-T3 expression was a useful indicator of tumor differentiation in early gastric cancer, and the expression had positive correlation with depth of tumor invasion and lymph node metastasis. METHODS: Using the specific antibody, we evaluated the expression of GalNAc-T3 in 125 early gastric cancers that were treated as classical gastrectomy with lymphadenectomy, and analyzed the relationship between the expression of GalNAc-T3 and clinicopathological features. | Human | EFNB1 | 1947 | ephrin-B1 | P =0.027]. Elevated levels of EPHB2 and EFNB1 were detected in substantial subsets of early gastric cancers. | Human | COMT | 1312 | catechol-O-methyltransferase | (-)-Epigallocatechin (EGC) and (-)-epigallocatechin-3-O-gallate (EGCG), isolated from green tea leaves, have been reported to prevent or diminish the occurrence of epileptic discharges induced by iron ions, and to inhibit catechol-O-methyltransferase. | Human | CDH1 | 999 | cadherin 1, type 1, E-cadherin (epithelial) | CDH1 mutations are associated with a risk of early-onset gastric cancer Prophylactic gastrectomies have been performed in several unaffected CDH1 mutation carriers; despite normal endoscopic examinations and negative gastric biopsy specimens, pathologic foci of early gastric cancer were found in all surgical specimens. | Human | BMP6 | 654 | bone morphogenetic protein 6 | Immunohistochemical study of epidermal growth factor and transforming growth factor-beta in the penetrating type of early gastric cancer. We performed an immunohistochemical study to clarify the role of growth factors (epidermal growth factor [EGF] and transforming growth factor-beta [TGF-beta]) in the PEN type of early gastric cancer. | Human | CEACAM1 | 634 | carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) | BGP expression in gastric epithelium and early gastric cancer. |
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